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Scandinavian Journal of Clinical and Laboratory Investigation Volume 52, 1992 - Issue 2
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Original Article

The reactivity of anti-porcine gastric inhibitory polypeptide (GIF) rabbit serum R65 with synthetic human and porcine GIF

A. J. Moody NOVO Research Institute, Bagsvaerd
,
T. Krarup NOVO Research Institute, Bagsvaerd; Department of Internal Medicine and Medical Gastroenterology C, Herlev University Hospital, Denmark
&
U. Dahl Larsen NOVO Research Institute, Bagsvaerd
Pages 103-106 | Received 01 Jul 1991, Accepted 26 Sep 1991, Published online: 08 Jul 2009

References

  • Brown J C, Mutt V, Pedersen R A. Further purification of a polypeptide demonstrating enterogastrone activity. J Physiol 1970; 209: 57–64
  • Jornvall H, Carlquist M, Kwauk S, Otte S, McIntosh S CH, Brown J C, Mutt V. Amino acid sequence and heterogeneity of gastric inhibitory polypeptide. Febs Lett 1981; 123: 205–10
  • Moody A J, Thim L, Valverde I. The isolation and sequencing of human gastric inhibitory peptide. Febs Lett 1984; 172: 142–8
  • Brown J C. Gastric Inhibitory Polypeptide. Springer Verlag, New York 1982
  • Krarup T, Hoist J J, Larsen K L. Responses and molecular heterogeneity of IR-OIP after intra-duodenal glucose and fat. Am J Physiol 1985; 249: E195–E200
  • Cleator I GM, Gourlay R H. Release of immuno-reactive gastric inhibitory polypeptide (IR-GIP) by oral ingestion of food substances. Am J Surg 1975; 130: 128–35
  • Jones I R, Owens D R, Moody A J, Luzio S D, Morris T, Hayes T M. The effects of glucose-dependent insulinotrophic polypeptide infused at physiological concentrations in normal subjects and Type 2 (non-insulin dependent) diabetic patients on glucose tolerance and B-cell secretion. Diabetologia 1987; 30: 707–12
  • Krarup T, Saurbrey N, Moody A J, Kuhl C, Madsbad S. Effect of porcine gastric inhibitory polypeptide on β-cell function in type I and type II diabetes mellitus. Metabolism 1987; 36: 677–82
  • Krarup T, Hoist J J, Madsbad S. Heterogeneity of immunoreactive gastric inhibitory polypeptide in the plasma of newly diagnosed type 1 (insulin-dependent) diabetics. Acta Endocrinol (Copenh) 1987; 114: 74–83
  • Moody A J, Damm Jorgensen K, Thim L. Structure function relationships in porcine GIP. Diabetologia Abs 1981; 21: 206
  • Wolffbrandt K H, Damm Jorgensen K, Moody A J. Pedersen PC. The effects of porcine GIP on insulin secretion and glucose clearance in the pig. Horm Metabol Res 1986; 18: 159–62
  • Lauritsen K, Moody A J. The response of gastric inhibitory polypeptide (GIP) and insulin to glucose in duodenal ulcer patients. Diabetologia 1978; 14: 149–53
  • Krarup T, Madsbad S, Moody A J, Regeur S, Faber O K, Hoist J J, Sestoft L. Diminished immunoreactive gastric inhibitory polypeptide response to a meal in newly diagnosed diabetics. J Clin Endocrinol Metabol 1983; 56: 1306–12

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