Hepatoid adenocarcinoma of the stomach – proper identification and treatment remain a challenge

References

• Ishikura H, Kirimoto K, Shamoto M, et al. Hepatoid adenocarcinomas of the stomach. An analysis of seven cases. Cancer. 1986;58:119–126.
   PubMed Web of Science ®Google Scholar
• Ishikura H, Fukasawa Y, Ogasawara K, et al. An AFP-producing gastric carcinoma with features of hepatic differentiation. A case report. Cancer. 1985;56:840–848.
   PubMed Web of Science ®Google Scholar
• Bourreille J, Metayer P, Sauger F, et al. Existence of alfa feto protein during gastric-origin secondary cancer of the liver. Presse Med. 1970;78:1277–1278.
   PubMed Web of Science ®Google Scholar
• Su JS, Chen YT, Wang RC, et al. Clinicopathological characteristics in the differential diagnosis of hepatoid adenocarcinoma: a literature review. World J Gastroenterol. 2013;19:321–327.
   PubMed Web of Science ®Google Scholar
• Wang XY, Bao WQ, Hua FC, et al. AFP-producing hepatoid adenocarcinoma of appendix: a case report of 18F-FDG PET/CT. Clin Imaging. 2014;38:526–528.
   PubMed Web of Science ®Google Scholar
• Marchegiani G, Gareer H, Parisi A, et al. Pancreatic hepatoid carcinoma: a review of the literature. Dig Surg. 2013;30:425–433.
   PubMed Web of Science ®Google Scholar
• Jung JY, Kim YJ, Kim HM, et al. Hepatoid carcinoma of the pancreas combined with neuroendocrine carcinoma. Gut Liver. 2010;4:98–102.
   PubMed Web of Science ®Google Scholar
• Lazaro J, Rubio D, Repolles M, et al. Hepatoid carcinoma of the ovary and management. Acta Obstet Gynecol Scand. 2007;86:498–499.
   PubMed Web of Science ®Google Scholar
• Takahashi Y, Inoue T. Hepatoid carcinoma of the uterus that collided with carcinosarcoma. Pathol Int. 2003;53: 323–326.
   PubMed Web of Science ®Google Scholar
• Arnould L, Drouot F, Fargeot P, et al. Hepatoid adenocarcinoma of the lung: report of a case of an unusual alpha-fetoprotein-producing lung tumor. Am J Surg Pathol. 1997;21:1113–1118.
   PubMed Web of Science ®Google Scholar
• Ishikura H, Kanda M, Ito M, et al. Hepatoid adenocarcinoma: a distinctive histological subtype of alpha-fetoprotein-producing lung carcinoma. Virchows Arch a Pathol Anat Histopathol. 1990;417:73–80.
   PubMedGoogle Scholar
• Roberts CC, Colby TV, Batts KP. Carcinoma of the stomach with hepatocyte differentiation (hepatoid adenocarcinoma). Mayo Clin Proceed. 1997;72:1154–1160.
   PubMed Web of Science ®Google Scholar
• Ren A, Cai F, Shang YN, et al. Gastric hepatoid adenocarcinoma: a computed tomography report of six cases. World J Gastroenterol. 2014;20:15001–15006.
   PubMed Web of Science ®Google Scholar
• Baek SK, Han SW, Oh DY, et al. Clinicopathologic characteristics and treatment outcomes of hepatoid adenocarcinoma of the stomach, a rare but unique subtype of gastric cancer. BMC Gastroenterol. 2011;11:56.
   PubMed Web of Science ®Google Scholar
• Nagai E, Ueyama T, Yao T, et al. Hepatoid adenocarcinoma of the stomach. A clinicopathologic and immunohistochemical analysis. Cancer. 1993;72:1827–1835.
   PubMed Web of Science ®Google Scholar
• Lee MW, Lee JY, Kim YJ, et al. Gastric hepatoid adenocarcinoma: CT findings. Abdom Imaging. 2007;32: 293–298.
   PubMed Web of Science ®Google Scholar
• Giustozzi G, Goracci G, Bufalari A, et al. Hepatoid carcinoma of the stomach: is it still an unusual anatomo-clinical entity? Six cases-report. J Exp Clin Cancer Res. 1999;18:571–573.
   PubMed Web of Science ®Google Scholar
• Gao YB, Zhang DF, Jin XL, et al. Preliminary study on the clinical and pathological relevance of gastric hepatoid adenocarcinoma. J Dig Dis. 2007;8:23–28.
   PubMed Web of Science ®Google Scholar
• Zhang JF, Shi SS, Shao YF, et al. Clinicopathological and prognostic features of hepatoid adenocarcinoma of the stomach. Chin Med J (Engl). 2011;124:1470–1476.
   PubMed Web of Science ®Google Scholar
• Yang J, Wang R, Zhang W, et al. Clinicopathological and prognostic characteristics of hepatoid adenocarcinoma of the stomach. Gastroenterol Res Pract. 2014;2014:140587
   PubMedGoogle Scholar
• Vivekanandarajah A, Atallah JP, Gupta S. Alpha-fetoprotein-producing nonmetastatic gastric adenocarcinoma: a rare entity. J Gastrointest Cancer. 2014;45:225–227.
   PubMedGoogle Scholar
• Ye MF, Tao F, Liu F, et al. Hepatoid adenocarcinoma of the stomach: a report of three cases. World J Gastroenterol. 2013;19:4437–4442.
   PubMed Web of Science ®Google Scholar
• Xie Y, Zhao Z, Li P, et al. Hepatoid adenocarcinoma of the stomach is a special and easily misdiagnosed or missed diagnosed subtype of gastric cancer with poor prognosis but curative for patients of pN0/1: the experience of a single center. Int J Clin Exp Med. 2015;8:6762–6772.
   PubMed Web of Science ®Google Scholar
• Hu B, El Hajj N, Sittler S, et al. Gastric cancer: Classification, histology and application of molecular pathology. J Gastrointest Oncol. 2012;3:251–261.
   PubMedGoogle Scholar
• Lin CY, Yeh HC, Hsu CM, et al. Clinicopathologial features of gastric hepatoid adenocarcinoma. Biomed J. 2015;38: 65–69.
   PubMed Web of Science ®Google Scholar
• Li C, Oh SJ, Kim S, et al. Macroscopic Borrmann type as a simple prognostic indicator in patients with advanced gastric cancer. Oncology. 2009;77:197–204.
   PubMed Web of Science ®Google Scholar
• Wu Z, Upadhyaya M, Zhu H, et al. Hepatoid adenocarcinoma: computed tomographic imaging findings with histopathologic correlation in 6 cases. J Comput Assist Tomogr. 2007;31:846–852.
   PubMed Web of Science ®Google Scholar
• Velut G, Mary F, Aflalo V, et al. Magnetic resonance imaging diffusion-weighted imaging for diagnosis of a gastric hepatoid adenocarcinoma. Dig Liver Dis. 2015;47:174
   PubMedGoogle Scholar
• Seo HJ, Chung JK, Go H, et al. A hepatoid adenocarcinoma of the stomach evaluated with (18)F-FDG PET/CT: intense (18)F-FDG uptake contrary to the previous report. Clin Nucl Med. 2014;39:442–445.
   PubMed Web of Science ®Google Scholar
• Fujii H, Ichikawa K, Takagaki T, et al. Genetic evolution of alpha fetoprotein producing gastric cancer. J Clin Pathol. 2003;56:942–949.
   PubMed Web of Science ®Google Scholar
• Supriatna Y, Kishimoto T, Uno T, et al. Evidence for hepatocellular differentiation in alpha-fetoprotein-negative gastric adenocarcinoma with hepatoid morphology: a study with in situ hybridisation for albumin mRNA. Pathology. 2005;37:211–215.
   PubMed Web of Science ®Google Scholar
• Terracciano LM, Glatz K, Mhawech P, et al. Hepatoid adenocarcinoma with liver metastasis mimicking hepatocellular carcinoma: an immunohistochemical and molecular study of eight cases. Am J Surg Pathol. 2003; 27:1302–1312.
   PubMed Web of Science ®Google Scholar
• Wee A, Thamboo TP, Thomas A. Alpha-fetoprotein-producing liver carcinomas of primary extrahepatic origin. Acta Cytol. 2003;47:799–808.
   PubMedGoogle Scholar
• Sentani K, Oue N, Sakamoto N, et al. Gene expression profiling with microarray and SAGE identifies PLUNC as a marker for hepatoid adenocarcinoma of the stomach. Mod Pathol. 2008;21:464–475.
   PubMed Web of Science ®Google Scholar
• Duffy MJ. Evidence for the clinical use of tumour markers. Ann Clin Biochem. 2004;41:370–377.
   PubMed Web of Science ®Google Scholar
• Ikeda H, Sato Y, Yoneda N, et al. Alpha-fetoprotein-producing gastric carcinoma and combined hepatocellular and cholangiocarcinoma show similar morphology but different histogenesis with respect to SALL4 expression. Hum Pathol. 2012;43:1955–1963.
   PubMed Web of Science ®Google Scholar
• Samaratunga H, Samaratunga D, Dunglison N, et al. Alpha-fetoprotein-producing carcinoma of the renal pelvis exhibiting hepatoid and urothelial differentiation. Anticancer Res. 2012;32:4987–4991.
   PubMed Web of Science ®Google Scholar
• Zhu X, Yong H, Zhang L, et al. Pure alpha-fetoprotein-producing neuroendocrine carcinoma of the pancreas: a case report. BMC Gastroenterol. 2015;15:16
   PubMed Web of Science ®Google Scholar
• Rassidakis GZ, Delladetsima JK, Letsos SP, et al. Hepatoid adenocarcinoma of the stomach with extensive neuroendocrine differentiation and a coexisting carcinoid tumour. Histopathology. 1998;33:8–186.
   Google Scholar
• Lam K, Lo C, Wat M, et al. Malignant insulinoma with hepatoid differentiation: a unique case with alpha-fetoprotein production. Endocr Pathol. 2001;12:351–354.
   PubMed Web of Science ®Google Scholar
• Metzgeroth G, Strobel P, Baumbusch T, et al. Hepatoid adenocarcinoma - review of the literature illustrated by a rare case originating in the peritoneal cavity. Onkologie. 2010;33:263–269.
   PubMedGoogle Scholar
• Wincewicz A, Kowalik A, Zieba S, et al. Alpha-fetoprotein-producing hepatoid gastric adenocarcinoma with osteoclast-like giant cells and neuroendocrine differentiation: a case study with molecular profiling. Int J Surg Pathol. 2015;23:537–541.
   PubMed Web of Science ®Google Scholar
• Suzuki A, Koide N, Kitazawa M, et al. Gastric composite tumor of alpha fetoprotein-producing carcinoma/hepatoid adenocarcinoma and endocrine carcinoma with reference to cellular phenotypes. Pathol Res Int. 2012;2012:201375.
   PubMedGoogle Scholar
• Okamoto T, Ogasahara K, Fujiki M, et al. Primary coexistent neuroendocrine carcinoma, hepatoid adenocarcinoma, and tubular adenocarcinoma of the stomach with focal trophoblastic differentiation in metastatic lymph nodes. J Gastroenterol. 2003;38:608–610.
   PubMed Web of Science ®Google Scholar
• Velut G, Mary F, Wind P, et al. Adjuvant chemotherapy by FOLFOX for gastric hepatoid adenocarcinoma. Dig Liver Dis. 2014;46:1135–1136.
   PubMedGoogle Scholar
• Kochi M, Fujii M, Kaiga T, et al. FLEP chemotherapy for alpha-fetoprotein-producing gastric cancer. Oncology. 2004;66:445–449.
   PubMed Web of Science ®Google Scholar
• Nakao S, Nakata B, Tendo M, et al. Salvage surgery after chemotherapy with S-1 plus cisplatin for alpha-fetoprotein-producing gastric cancer with a portal vein tumor thrombus: a case report. BMC Surg. 2015;15:5.
   PubMed Web of Science ®Google Scholar
• Takeyama H, Sawai H, Wakasugi T, et al. Successful paclitaxel-based chemotherapy for an alpha-fetoprotein-producing gastric cancer patient with multiple liver metastases. World J Surg Oncol. 2007;5:79
   PubMedGoogle Scholar
• Shimada S, Hayashi N, Marutsuka T, et al. Irinotecan plus low-dose cisplatin for alpha-fetoprotein-producing gastric carcinoma with multiple liver metastases: report of two cases. Surg Today. 2002;32:1075–1080.
   PubMed Web of Science ®Google Scholar
• Koide N, Nishio A, Igarashi J, et al. Alpha-fetoprotein-producing gastric cancer: histochemical analysis of cell proliferation, apoptosis, and angiogenesis. Am J Gastroenterol. 1999;94:1658–1663.
   PubMed Web of Science ®Google Scholar