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Original Article

The Antigastrolesive Activity of Rioprostil, a 16-Methyl Prostaglandin-E! Analogue in Healthy Volunteers

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Pages 81-91 | Published online: 08 Jul 2009

References

  • Grossman M, Kurata J H, Rotter J I, Meyer J H, et al. Peptic ulcer: New therapies, new diseases. Ann Intern Med 1981; 95: 609–627
  • Robert A. Cytoprotection by Prostaglandins. Gastroenterology 1979; 77: 761–767
  • Wilson D E, Kaymakcalan H. prostaglandins: Gastrointestinal effects and peptic ulcer disease. Med Clin North Am 1981; 65(4)773–787
  • Robert A, Nezamis J E, Phillips J P. Inhibition of gastric secretion by prostaglandins. Am J Dig Dis 1967; 12: 1073–1076
  • Wilson D E, Phillips C, Levine R A. Inhibition of gastric secretion in man by prostaglandin A. Gastroenterology 1971; 61: 201–206
  • Karim S MM, Carter D C, Bhana D, Ganesan P A. Effect of orally and intravenously administered prostaglandin 15(R)-15-methyl E2 on gastric secretion in man. Adv Biosci 1973; 9: 255–264
  • Robert A, Nezamis J E, Phillips J P. Effect of prostaglandin E1 on gastric secretion and ulcer formation in the rat. Gastroenterology 1968; 55: 481–487
  • Robert A. Antisecretory, antiulcer, cytoprotective and diarrheogenic properties of prostaglandins. Advances in prostaglandin and thromboxane research, B Samuelsson, R Paolleti. Raven Press, New York 1976; 2: 507–520
  • Gibinski K, Rybicka J, Mikos E, Nowak A. Double-blind clinical trial on gastroduodenal ulcer healing with prostaglandin E2 analogues. Gut 1977; 8: 636–639
  • Robert A, Nazamis J E, Lancaster C, Hanchar A J. Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HC1, NaOH, hypertonic NaCl, and thermal injury. Gastroenterology 1979; 77: 433–443
  • Miller T A, Jacobson E D. Progress report. Gastrointestinal cytoprotection by prostaglandins. Gut 1979; 20: 75–87
  • Robert A, Hanchar A J, Nezamis J E, Lancaster C. Cytoprotection against acidified aspirin: comparison of prostaglandin, cimetidine, and proban-thine. Gastroenterology 1979; 76: 1227
  • Robert A. Current history of cytoprotection. Prostaglandins 1981; 21(suppl)89–96
  • Katz L B, Genna T, Shriver D A. Antiulcer effect of rioprostil, a prostaglandin E1 analog, in combination with antacid. Life Sci 1986; 39: 1013–1019
  • Katz L B, Capetola R J, Argentieri D C, et al. Rioprostil prevents gastric bleeding inducted by nonsteroidal antiinflammatory drugs in dogs and arthritic rats. J Rheumatol 1986; 13(5)887–894
  • Cohen M M, Cheung G, Lyster D M. Prevention of aspirin-induced faecal blood loss by prostaglandin E2. Gut 1980; 21: 602–606
  • Johansson C, Kollberg B, Nordemar R, Samuelson K, Bergstrom S. Protective effect of prostaglandin E2 in the gastrointestinal tract during indomethacin treatment of rheumatic diseases. Gastroenterology 1980; 78: 479–483
  • Karim S MM, Carter D C, Bhana D, Ganesan P A. Effect of orally administered prostaglandin E2 and its 15-methyl analogues on gastric secretion. Br Med J 1973; 1: 143–146
  • Cohen M M, Clark L, Armstrong L, Souza J. Reduction of aspirin-induced faecal blood loss with low-dose misoprostol tablets in man. Dig Dis Sci 1985; 30(7)605–611
  • Gilbert D A, Surawicz C M, Silverstein F E, et al. Prevention of acute aspirin-induced gastric mucosal injury by 15-R-15 methyl prostaglandin E2: An endoscopic study. Gastroenterology 1984; 86: 339–345
  • Cohen M M, McCready D R, Clark L, Sevelius H. Protection against aspirin-induced antral and duodenal damage with enprostil. A double-blind endoscopic study. Gastroenterology 1985; 88: 382–386
  • Brand D L, Roufail W M, Thomson A BR, Tapper E J. Misoprostol, a synthetic PGE1, analog, in the treatment of duodenal ulcers. A multicenter double-blind study. Dig Dis Sci 1985; 30: 147S–158S
  • Vantrappen G, Janssens J, Popiela T, et al. Effect of 15-R-15 methyl prostaglandin E2 (Araprostil) on the healing of duodenal ulcer. A double-blind multicenter study. Gastroenterology 1982; 83: 357–363
  • Johansson C, Kollberg B. Clinical trials with prostaglandin E2. Prostaglandins 1981; 21(suppl)161–164
  • Lacy E R, Ito S. Microscopic analysis of ethanol damage to rat gastric mucosa after treatment with a prostaglandin. Gastroenterology 1982; 83: 619–625
  • Schmidt K L, Henagan J M, Smith G S, Hilburn P J, Miller T A. Prostaglandin cytoprotection against ethanol-induced gastric injury in the rat a histologic and cytologic study. Gastroenterology 1985; 88: 649–659
  • Robert A. Role of endogenous and exogenous prostaglandins in mucosal protection. Mechanisms of mucosal protection in the upper gastrointestinal tract, A Allen, G Flemström, A Garner, W Silan, L A Turnberg. Raven Press, New York 1984; 377–382
  • Shriver D A, Rosenthale M E, Kluender H C, Schut R L, McGuire J L, Hong E. Pharmacology of rioprostil, a new gastric cytoprotective/antisecretory agent. Arzneim Forsch/Drug Res 1985; 35: 839–843
  • Holt P R. Measurement of gastrointestinal blood loss in subjects taking aspirin. J Lab Clin Med 1960; 56: 717–726
  • Demol P, Wingender W, Weihrauch T R, Graefe K H. Inhibition of gastric secretion in man by rioprostil, a new synthetic methyl prostaglandin E1. Arzneim Forsch/Drug Res 1985; 35: 861–863
  • Singer M V, Schulte H, Demol P, Sysselein V, Goeb-Ell H. Dose response effects of rioprostil, a new synthetic methyl prostaglandin E, on gastric-acid secretion and release of gastrin in humans. Gastroenterology 1985; 88: 1588
  • Hillier K, Smith C L, Jewell R, Arthur M JP, Ross G. Duodenal mucosa synthesis of prostaglandins and the gastrointestinal mucosa are they important in its function, disease, or treatment?. Gastroenterology 1985; 89: 1162–1188
  • Sharon P, Cohen F, Zifroni A, Karmeli F, Ligumsky M, Rachmilewitz D. Prostanoid synthesis by cultured gastric and duodenal mucosa: possible role in the pathogenesis of duodenal ulcer. Scand J Gastroenterol 1983; 18: 1045–1049
  • Ahlquist D A, Dozois R R, Zinsmeister A R, Mala-Gelada J-R. Duodenal prostaglandin synthesis and acid load in health and in duodenal ulcer disease. Gastroenterology 1983; 85: 522–528
  • Wright J P, Young G O, Klaff U, Weers L A, Price S K, Marks I N. Gastric mucosal prostaglandin E levels in patients with gastric ulcer disease and carcinoma. Gastroenterology 1982; 82: 263–267
  • Konturek S J. Prostaglandins in pathophysiology of peptic ulcer disease. Dig Dis Sci 1985; 30: 105S–108S
  • Robert A, Lancaster C, Hanchar A, Nezamis J E. Mild irritants prevent gastric necrosis through prostaglandin formation: histological study. Gastroenterology 1978; 74: 1086
  • Chaudhury T K, Robert A. Prevention by mild irritants of gastric necrosis produced in rats by sodium tauraocholate. Dig Dis Sci 1980; 25: 830–836
  • Konturek S J, Brzozowski T, Plastucki I, Radecki T, Dembiński A, Dembińska-Kieć A. Role of locally generated prostaglandins in adaptive gastric cytoprotection. Dig Dis Sci 1982; 27(11)967–971
  • Bolton J P, Palmer D, Cohen M M. Stimulation of mucus and nonparietal cell secretion by the E2 prostaglandins. Am J Dig Dis 1978; 23: 359–364
  • Johansson C, Kollberg B. Stimulation by intra-gastrically administered E2 prostaglandins of human gastric mucus output. Eur J Clin Invest 1979; 9: 229–232
  • Kauffman G L, Reeve J J, Jr, Grossman M I. Gastric bicarbonate secretion: effect of topical and intravenous 16, 16-dimethyl prostaglandin E2. Am J Physiol 1980; 239: G44–G48
  • Garner A, Heylings J R. Stimulation of alkaline secretion in amphibian-isolated gastric mucosa by 16,16-dimethyl PGE2 and PGF2. Gastroenterology 1979; 76: 497–503
  • Kollberg B, Aly A, Johansson C. Protection of the rat gastric mucosa by prostaglandin E2: possible relation to stimulation of the alkaline secretion. Acta Physiol Scand 1981; 113: 189–192
  • Guth P H, Paulsen G, Nagata H, Leung F, Robert A, Ohya Y. Prostaglandin cytoprotection: role of microcirculatory changes. Adv Prostaglandin Thromboxane Res 1985; 15: 637–639
  • Konturek S J, Bowman J, Lancaster C, Hanchar A J, Robert A. Cytoprotection of the canine gastric mucosa by prostaglandins: possible mediation by increased mucosal blood flow. Gastroenterology 1979; 76: 1173
  • Dajani E Z, Callison D A, Bertermann R E. Effects of E prostaglandins on canine gastric potential difference. Am J Dig Dis 1978; 23: 436–442
  • Ito S, Lacy E R, Rutten M J, Critchlow J, Silen W. Rapid repair of injured gastric mucosa. Scand J Gastroenterol 1984; 19(suppl 101)87–95
  • Lacy E R. Prostaglandins and histological changes in the gastric mucosa. Dig Dis Sci 1985; 30(suppl)83S–94S
  • Rajapaksa T, Adams A, Ramsamooj E, Quadros E, Wilson D E. The effects of an oral prostaglandin E1 analog on gastric acid and mucus secretion in man. Clin Res 1983; 31: 766A
  • Demol P, Schmitz H D, Weihrauch T R, Kuhlmann J. Prevention of the acetylsalicylic acid-induced changes of the gastric potential difference by the new synthetic prostaglandin E, analogue rioprostil. Arzneim Forsch/Drug Res 1986; 36: 1406–1408
  • Davenport H W. Back diffusion of acid through the gastric mucosa and its physiological consequences. Progress in gastroenterology, G B Jerzy Glass. Grune & Stratton, New York 1970; Vol II: 42–56
  • Winterhager J M. Effects of rioprostil, PGE, and dimethyl PGE2 on HCO3 secretion by guinea-pig fundic mucosa in vitro. Naunyn Schmiedebergs Arch Pharmacol 1986; 332: R62
  • Euler A R, Tytgat G, Berengeur J, Brunner H, Wood D R, Lookabaugh J L, Phan T D. Failure of a cytoprotective dose of arbaprostil to heal acute duodenal ulcers. Results of a multiclinic trial. Gastroenterol 1987; 92: 604–607

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