NSAIDs and the Gastrointestinal Tract—Case Closed?

References

• Vane J R. Inhibition of prostaglandin synthesis as a mechanism for aspirin-like drugs. Nature New Biol 1971; 281: 232–235
   Google Scholar
• Roth S H, Bennett R E. Nonsteroidal anti-inflammatory drug gastropathy. Recognition and response. Arch Intern Med 1987; 147: 2093–2100
   PubMedGoogle Scholar
• Graham D Y. Prevention of gastroduodenal injury induced by chronic nonsteroidal inflammatory drug therapy. Gastroenterology 1989; 96: 675–681
   PubMed Web of Science ®Google Scholar
• Aabakken L, Osnes M. Gastroduodenal lesions induced by naproxen: an endoscopic evaluation of regional differences and natural course. Scand J Gastroenterol 1990; 25: 1215–1222
   PubMed Web of Science ®Google Scholar
• Aabakken L, Larsen S, Osnes M. Visual analogue scales for endoscopic evaluation of NSAID-induced mucosal damage in the stomach and duodenum. Scand J Gastroenterol 1990; 25: 443–448
   PubMed Web of Science ®Google Scholar
• Day T K. Intestinal perforation associated with osmotic slow release indomethacin capsules. Br Med J 1983; 287: 1671–1672
   PubMed Web of Science ®Google Scholar
• Kent T H, Cardelli R M, Stamler F W. Small intestinal ulcers and intestinal flora in rats given indomethacin. Am J Pathol 1969; 54: 237–245
   PubMed Web of Science ®Google Scholar
• Beck W S, Schneider H T, Dietzel K, Nuernberg B, Brune K. Gastrointestinal ulcerations induced by anti-inflammatory drugs in rats. Physicochemical and biochemical factors involved. Arch Toxicol 1990; 64: 210–217
   PubMed Web of Science ®Google Scholar
• Brodie D A, Cook P G, Bauer B J, Dagle G E. Indomethacin-induced intestinal lesions in the rat. Toxicol Appl Pharmacol 1970; 17: 615–624
   PubMed Web of Science ®Google Scholar
• Rampton D S, McNeil N I, Sarner M. Analgesic ingestion and other factors preceding relapse in ulcerative colitis. Gut 1983; 24: 187–189
   PubMed Web of Science ®Google Scholar
• Bjarnason I, Lang J, Gumpel M J, Levi A J, Price A B. Non-steroidal anti-inflammatory drugs (NSAIDs) and intestinal pathology [Abstract]. Gastroenterology 1986; 90: 1347
   Google Scholar
• Myszor M, Hodgson J F. Non-steroidal antiinflammatory drugs and gastric DNA synthesis. Scand J Gastroenterol 1990; 25: 197–202
   PubMed Web of Science ®Google Scholar
• Bjarnason I, Zanelli G, Prouse P, Williams P, Gumpel M J, Levi A J. Effect of non-steroidal anti-inflammatory drugs on the human small intestine. Drugs 1986; 32(suppl 1)35–41
   PubMedGoogle Scholar
• Aabakken L. 51Cr-ethylenediaminetetraacetic acid absorption test. Effects of naproxen, a non-steroidal, antiinflammatory drug. Scand J Gastroenterol 1990; 25: 917–924
   PubMed Web of Science ®Google Scholar
• Krugliak P, Hollander D, Le K, Ma T, Dadufalza V D, Katz K D. Regulation of polyethylene glycol 400 intestinal permeability by endogenous and exogenous prostanoids. Influence of non-steroidal, antiinflammatory drugs. Gut 1990; 31: 417–421
   Google Scholar
• Olaison G, Sjödahl R, Tagesson C. Abnormal intestinal permeability in Crohn's disease. A possible pathogenic factor. Scand J Gastroenterol 1990; 25: 321–328
   PubMed Web of Science ®Google Scholar
• Bjarnason I, Williams P, Zanelli G, et al. Nonsteroidal anti-inflammatory drug (NSAID) induced ileocaecal inflammation in man [Abstract]. Gastroenterology 1985; 88: 1327
   Google Scholar
• Bjarnason I, Prouse P, Smith T, et al. Blood and protein loss via small-intestinal inflammation induced by non-steroidal anti-inflammatory drugs. Lancet 1987; 2: 711–714
   PubMed Web of Science ®Google Scholar
• Robert A. Cytoprotection by prostaglandins. Gastroenterology 1979; 77: 761–767
   PubMed Web of Science ®Google Scholar
• Stodolnik E, Maurer P, Hoigne R, et al. Risk of acute upper gastrointestinal bleeding in patients with ulcerative disease and treatment with nonsteroidal anti-inflammatory drugs (NSAIDs). Eur J Clin Pharmacol 1990; 38: 31–35
   PubMed Web of Science ®Google Scholar
• Okada M, Niida H, Takeuchi K, Okabe S. Role of prostaglandin deficiency in pathogenetic mechanism of gastric lesions induced by indomethacin in the rat. Dig Dis Sci 1989; 34: 694–702
   PubMed Web of Science ®Google Scholar
• Konturek S J, Brzozowski T, Drozdowicz D, Beck G. Role of leukotrienes in acute gastric lesions induced by ethanol, taurocholate, aspirin, platelet-activating factor and stress in rats. Dig Dis Sci 1988; 33: 806–814
   PubMed Web of Science ®Google Scholar
• Del Soldato P, Foschi D, Benoni G, Scarpignato C. Oxygen free radicals interact with indomethacin to cause gastrointestinal injury. Agents Actions 1985; 17: 484–488
   Google Scholar
• Robert A. An intestinal disease produced experimentally by prostaglandin deficiency. Gastroenterology 1975; 69: 1045–1047
   PubMed Web of Science ®Google Scholar
• Redfern I S, Feldman M. Role of endogenous prostaglandins in preventing gastrointestinal ulceration: induction of ulcers by antibodies to prostaglandins. Gastroenterology 1989; 96: 596–605
   Google Scholar
• Kauffman G. Aspirin-induced gastric mucosal injury: lessons learned from animal models. Gastroenterology 1989; 96: 606–614
   PubMed Web of Science ®Google Scholar
• Aabakken L, Bjørnbeth B A, Hofstad B, Olaussen B, Larsen S, Osnes M. Comparison of the gastrointestinal side effects of naproxen formulated as plain tablets, enteric-coated tablets, or enteric-coated granules in capsules. Scand J Gastroenterol 1989; 24(suppl 163)65–73
   PubMed Web of Science ®Google Scholar
• Anonymous. CSM update: Non-steroidal antiinflammatory drugs and serious gastrointestinal adverse reactions. I. Br Med J 1986; 292: 614
   Google Scholar
• Hoftiezer J W, Silvoso G R, Burks M, Ivey K J. Comparison of the effects of regular and enteric-coated aspirin on gastroduodenal mucosa of man. Lancet 1980; 2: 609–612
   PubMed Web of Science ®Google Scholar
• Lanza F L, Rack M F, Wagner G S, Balm T K. Reduction in gastric mucosal hemorrhage and ulceration with chronic high-level dosing of enteric-coated aspirin granules two and four times a day. Dig Dis Sci 1985; 36: 509–512
   Google Scholar
• Oddsson E, Gudjonsson H, Thjodleifsson B. Endoscopic findings in the stomach and duodenum after treatment with enteric coated and plain naproxen tablets in healthy subjects. Scand J Gastroenterol 1990; 25: 231–234
   PubMed Web of Science ®Google Scholar
• Ehsanullah R SB, Page M C, Tildesley G, Wood J R. Prevention of gastroduodenal damage induced by non-steroidal anti-inflammatory drugs: controlled trial of ranitidine. Br Med J 1988; 297: 1017–1021
   PubMed Web of Science ®Google Scholar
• Berkowitz J M, Rogenes P R, Sharp J T, Warner C W. Ranitidine protects against gastroduodenal lesions associated with chronic aspirin therapy. Arch Intern Med 1987; 147: 2137–2139
   PubMedGoogle Scholar
• Roth S H, Bennett R E, Mitchell C S, Hartmann R J. Cimetidine therapy in nonsteroidal antiinflammatory drug gastropathy. Arch Intern Med 1987; 147: 1798–1801
   PubMedGoogle Scholar
• Stiel D, Ellard K T, Hills L J, Brooks P M. Protective effect of enprostil against aspirin-induced gastroduodenal mucosal injury in man. Comparison with cimetidine and sucralfate. Am J Med 1986; 81: 54–58
   Google Scholar
• Aabakken L, Bjørnbeth B A, Weberg R, Viksmoen L, Larsen S, Osnes M. NSAID-associated gastroduodenal damage: does famotidine protection extend into the mid- and distal duodenum?. Aliment Pharmacol Ther 1990; 4: 295–303
   PubMed Web of Science ®Google Scholar
• Aabakken L, Larsen S, Osnes M. Cimetidine tablets or suspension in the prevention of gastrointestinal mucosal lesions caused by non-steroidal, antiinflammatory drugs. Scand J Rheumatol 1989; 18: 369–375
   PubMed Web of Science ®Google Scholar
• Aabakken L, Larsen S, Osnes M. Sucralfate for prevention of naproxen-induced mucosal lesions. Scand J Rheumatol 1989; 18: 361–368
   PubMed Web of Science ®Google Scholar
• Bjarnason I, Smethurst P, Fenn G C, Lee C E, Levi A J. Misoprostol reduces indomethacin-induced changes in human small intestinal permeability. Dig Dis Sci 1989; 34: 407–411
   PubMed Web of Science ®Google Scholar
• Bianchi-Porro G, Pace G, Caruso I. Why are nonsteroidal anti-inflammatory drugs important in peptic ulceration. Aliment Pharmacol Ther 1987; 1: 540–547
   Google Scholar
• Simon B, Beckers K H, Biewer W, et al. Ranitidine in the therapy of NSAID-induced gastroduodenal lesions: results of a randomized, placebo-controlled double blind study in patients with rheumatic disease. Z Gastroenterol 1988; 26: 310–313
   Google Scholar
• Walan A, Bader J P, Classen M, et al. Effect of omeprazole and ranitidine on ulcer healing and relapse rates in patients with benign gastric ulcer. N Engl J Med 1989; 320: 69–75
   PubMed Web of Science ®Google Scholar
• Wallin B A, Frank W O, Fox M J, et al. The effects of cimetidine on the healing of nonsteroidal antiinflammatory drug-induced gastroduodenal damage while continuing NSAID therapy [Abstract]. Am J Gastroenterol 1988; 83: 1076
   Google Scholar