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Original Article

The Mode of Action of Sucralfate: The 1×1×1 Mechanism of Action

Pages 7-12 | Published online: 08 Jul 2009

References

  • Marks I N, Samloff I M. Sucralfate in peptic ulcer disease and gastritis: a worldwide view. Am J Med 1985; 79(suppl 2C)1–64
  • Szabo S, Bynum T E. Alternatives to the acid-oriented aooroach to ulcer disease: does ‘cvtooro-tection’ exist in man? A new classification of anti-ulcer agents. Scand J Gastroenterol 1988; 23: 1–6
  • Szabo S, Hollander D. Pathways of gastrointestinal protection and repair: mechanisms of action of sucralfate. Am J Med 1989; 86(suppl 6A)23–31
  • Nagashima R, Hirano T. Selective binding of sucralfate to ulcer lesions. I. Experiments in rats with acetic acid-induced gastric ulcer receiving un-labelled sucralfate. Arzneimittelforsch 1980; 30: 80–83
  • Tarnawski A, Hollander D, Krause W J, Zipser R D, Gergely H. Does sucralfate affect the normal gastric mucosa? Histologic, ultrastructural and functional assessment. Gastroenterology 1986; 90: 893–905
  • Nakasano S, Nagashima R, Samloff M. Selective binding of sucralfate to gastric ulcer in man. Dig Dis Sci 1981; 26: 297–300
  • Yamamoto E, Okabe S. Effects of sucralfate on healing of chronic gastric ulcers in rats. New pharmacology of ulcer disease: experimental and new therapeutic approaches, S Szabo, G Mozsik. Elsevier, New York 1987; 413–423
  • Hollander D, Tarnawski A. Protective effect of sucralfate on the gastric mucosa mediated by endogenous prostaglandins. New pharmacology of ulcer disease: experimental and new therapeutic approaches, S Szabo, G Mozsik. Elsevier, New York 1987; 404–412
  • Hollander D, Tarnawski A, Gergely H, Zipser R D. Sucralfate protection of the gastric mucosa against ethanol-induced injury: a prostaglandin-mediated process'?. Scand J Gastroenterol 1984; 19(suppl 101)97–102
  • Lam S K. Implications of sucralfate-induced ulcer healing and relapse. Am J Med 1989; 86(suppl 6A)122–126
  • Szabo S, Brown A. Prevention of ethanol-induced vascular injury and gastric mucosal lesions by sucralfate and its components: possible role of endogenous sulfhydryls. Proc Soc Exp Biol Med 1987; 185: 493–497
  • Szabo S. Critical and timely review of the concept of gastric cytoprotection. Acta Physiol Hung 1989; 73: 115–127
  • Nexa E, Poulsen S S. Does epidermal growth factor play a role in the action of sucralfate?. Scand J Gastroenterol 1987; 22(suppl 127)45–49
  • Folkman J, Klagsburn M. Angiogenic factors. Science 1987; 235: 442–447
  • Yamada T, Boland C R. Cellular mechanisms of sucralfate and sucrose octasulphate (SOS) action. Proceedings of the 6th International Sucralfate Symposium, Gold CoastAustralia, August 19–21, 1990, 20
  • Szabo S, Trier J S, Brown A, Schnoor J. Early vascular injury and increased vascular permeability in gastric mucosal injury caused by ethanol in the rat. Gastroenterology 1985; 88: 226–236
  • Pihan G, Majzoubi D, Haudenschild C, Trier J S, Szabo S. Early microcirculatory stasis in acute gastric mucosal injury in the rat and prevention by 16,16-dimethyl prostaglandin E2 or sodium thiosulfate. Gastroenterology 1986; 91: 966–974
  • Lacey E R, Ito S. Rapid epithelial restitution in the rat gastric mucosa after ethanol injury. Lab Invest 1984; 51: 573–583
  • Feil W, Klimesch S, Karner P, et al. Importance of an alkaline microenvironment for rapid restitution of the rabbit duodenal mucosa in vitro. Gastroenterology 1989; 97: 112–122
  • Dupuy D, Kronague J F, Jones A G, Szabo S. Gastric mucosal protection may be mediated through increases in vascular permeability which create a histodilutional barrier. Gastroenterology 1988; 94: A615
  • Palitzsch K D, Morales R E, Kronague J F, Szabo S. Biphasic effect of histamine on hemorrhagic mucosal lesions is related to vascular permeability: studies with histamine, H1, H2 and H3-antagonists and bradykinin. Gastroenterology 1989; 96: A381
  • Robert A, Lancaster C, Gilbertson-Beadling S, Olafsson A S, Guth P H. Gastric adaptation to aspirin-induced gastric erosions in rats. Gastroenterology 1989; 96: A418
  • Lippe I T, Szabo S. New mechanism of mucosal protection: gastroprotective prostaglandin and sulfhydryls delay the absorption of ethanol and 14C-aspirin from the rat stomach. Gastroenterology 1990; 98: A79
  • Allen A, Garner A. Mucus and bicarbonate secretion in the stomach and their possible role in mucosal protection. Gut 1980; 21: 249–262
  • Flemström G, Turnberg L A. Gastroduodenal defense mechanisms. Clin Gastroenterol 1984; 13: 327–354
  • Folkman J, Szabo S, Shing Y. Sucralfate affinity for fibroblast growth factor. J Cell Biol 1990; 111: 223A
  • Szabo S, Vattay P, Scarbrough E, Folkman J. Role of vascular factors, including angiogenesis in the mechanism of action of sucralfate. Am J Med 1991, (in press)

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