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Scandinavian Journal of Gastroenterology Volume 27, 1992 - Issue 3
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Original Article

Disappearance of Hepatitis C Virus RNA in Plasma during Interferon Alpha-2B Treatment in Hemophilia Patients

D. Bresters Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, and Academic Medical Centre, Amsterdam, and Van Crevcld Clinic Bilthoven The Netherlands, and Chiron Corporation, Emeryville, California, USA
,
E. P. Mauser-Bunschoten Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, and Academic Medical Centre, Amsterdam, and Van Crevcld Clinic Bilthoven The Netherlands, and Chiron Corporation, Emeryville, California, USA
,
H. T. M. Cuypers Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, and Academic Medical Centre, Amsterdam, and Van Crevcld Clinic Bilthoven The Netherlands, and Chiron Corporation, Emeryville, California, USA
,
P. N. Lelie Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, and Academic Medical Centre, Amsterdam, and Van Crevcld Clinic Bilthoven The Netherlands, and Chiron Corporation, Emeryville, California, USA
,
J. H. Han Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, and Academic Medical Centre, Amsterdam, and Van Crevcld Clinic Bilthoven The Netherlands, and Chiron Corporation, Emeryville, California, USA
,
P. L. M. Jansen Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, and Academic Medical Centre, Amsterdam, and Van Crevcld Clinic Bilthoven The Netherlands, and Chiron Corporation, Emeryville, California, USA
,
M. Houghton & Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, and Academic Medical Centre, Amsterdam, and Van Crevcld Clinic Bilthoven The Netherlands, and Chiron Corporation, Emeryville, California, USA
&
H. W. Reesink Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, and Academic Medical Centre, Amsterdam, and Van Crevcld Clinic Bilthoven The Netherlands, and Chiron Corporation, Emeryville, California, USA
 show all
Pages 166-168 | Received 26 Jul 1991, Accepted 14 Sep 1991, Published online: 08 Jul 2009

References

  • Makris M, Preston F E, Triger D R, et al. Hepatitis C antibody and chronic liver disease in haemophilia. Lancet 1990; 335: 117–1119
  • Brettler D B, Alter H J, Dienstag J L, Forsberg A D, Levine P H. Prevalence of hepatitis C virus antibody in a cohort of hemophilia patients. Blood 1990; 76: 254–256
  • Dienstag J L. Non-A, non-B hepatitis. I. Recognition, epidemiology and clinical features. Gastroenterology 1983; 85: 439–462
  • Schvarcz R, Weiland O, Wejstal R, Norkrans G, Fryden A, Foberg U. A randomized controlled open study of interferon alpha-2B treatment of chronic non-A, non-B posttransfusion hepatitis: no correlation of outcome to presence of hepatitis C virus antibodies. Scand J Infect Dis 1989; 21: 617–625
  • David G L, Balart L A, Schiff E R, et al. Treatment of chronic hepatitis C with recombinant interferon alpha. A multicenter randomized, controlled trial. N Engl J Med 1989; 321: 1501–1506
  • Marcellin P, Boyer N, Giostra E, et al. Recombinant human α-interferon in patients with chronic non-A, non-B hepatitis: a multicenter randomized controlled trial from France. Hepatology 1991; 13: 393–397
  • Han J H, Shyamala V, Richman K H, et al. Characterization of the terminal regions of hepatitis C viral RNA: identification of conserved sequences in the 5′ untranslated region and poly (A) tails at the 3′ end. Proc Natl Acad Sci 1991; 88: 1711–1715
  • Van der Poel C L, Cuypers H TM, Reesink H W, et al. Confirmation of hepatitis C virus infection by second generation four-antigen recombinant immunoblot assay and polymerase chain reaction. Lancet 1991; 337: 317–319

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