Pancreatic Cancer: The Role of Cholecystokinin?

References

• Townsend C. M., Singh P., Thompson J. C. Gastrointestinal hormones and gastrointestinal and pancreatic cancers. Gastroenterology 1986; 91: 1002–6
   PubMed Web of Science ®Google Scholar
• Lamers C. B H W, Jansen J. B M J. Role of gastrin and cho-lecystokinin in tumours of the gastrointestinal tract. Eur J Cancer Clin Oncol 1988; 24: 267–73
   PubMedGoogle Scholar
• Morris D. I., Watson S. A., Durrant I. G., Harrison J. D. Hormonal control of gastric and colorectal cancer in man. Gut 1989; 30: 425–429
   PubMed Web of Science ®Google Scholar
• Axelson J., Håkanson R., Ihse I., Lilja I., Rehfeld J. F., Sundler F. Effects of endogenous and exogenous cholecystokinin and of infusion with the cholecystokinin antagonist L-364,718 on pancreatic and gastrointestinal growth. Scand J Gastroenterol 1990; 25: 471–80
   PubMed Web of Science ®Google Scholar
• Håkanson R., Axelson J., Ihse I., Sundler F. The targets for the trophic action of gastrin and cholecystokinin. The stomach as an endocrine organ, R. Hakanson, F. Sundler. Elsevier Science Publishers, Amsterdam 1991; 307–20
   Google Scholar
• Longnecker D. S. Interface between adaptive and neoplastic growth in the pancreas. Gut 1987; 28(Suppl 1)253–8
   PubMedGoogle Scholar
• Upp J. R., Singh P., Townsend C. M., Thompson J. C. Clinical significance of gastrin receptors in human colon cancers. Cancer Res 1989; 49: 488–92
   PubMed Web of Science ®Google Scholar
• Creutzfeldt W. The achlorhydria-carcinoid sequence: role of gastrin. Digestion 1988; 39: 61–79
   PubMed Web of Science ®Google Scholar
• Lamers C. B., Jansen J. B., Woutersen R. A. Cholecystokinin and gastrointestinal cancer. J Steroid Biochem Mol Biol 1990; 37: 1069–72
   PubMed Web of Science ®Google Scholar
• Borch K., Kullman E., Ledin T., Ihse I. Increased incidence of pancreatic neoplasia in pernicious anemia. World J Surg 1988; 12: 866–70
   PubMed Web of Science ®Google Scholar
• Lamers C. H B W, Douglas B. R., Jansen J. B. Cholecystokinin and pancreatic cancer. Scand J Gastroenterol 1988; 23(Suppl 154)103–6
   PubMedGoogle Scholar
• Ihse I. The importance of cholecystokinin in pancreatic cancer. Int J Pancreatol 1992, In press
   Google Scholar
• Solomon T. E. Regulation of pancreatic secretion. Clin Gastroenterol 1984; 13: 657–78
   PubMedGoogle Scholar
• Dourish C. T., Hill D. R. Classification and function of CCK receptors. Trends Pharmacol Sci 1987; 8: 207–8
   Web of Science ®Google Scholar
• Innis R. B., Snyder S. H. Distinct cholecystokinin receptors in brain and pancreas. Proc Natl Acad Sci USA 1980; 77: 6917–21
   PubMed Web of Science ®Google Scholar
• Jensen R. T., Lemp G. F., Gardner J. D. Interactions of COOH-terminal fragments of cholecystokinin with receptors on dispersed acini from guinea pig pancreas. J Biol Chem 1982; 257: 5554–9
   PubMed Web of Science ®Google Scholar
• Shaw M. J., Hadace E. M., Miller L. J. Preparation of enriched plasma membranes from bovine gallbladder muscularis for characterization of cholecystokinin receptors. J Biol Chem 1987; 262: 14313–8
   PubMed Web of Science ®Google Scholar
• Soil A. H., Amirian D. A., Thomas L. P., Reedy T. J., Elashoff J. D. Gastrin receptors on isolated canine parietal cells. J Clin Invest 1984; 73: 1434–47
   PubMed Web of Science ®Google Scholar
• Yu D.-H., Noguchi M., Zhou Z.-C., Villanueva M. L., Gardner J. D., Jensen R. T. Characterization of gastrin receptors on guinea pig pancreatic acini. Am J Physiol 1987; 253: 0793–801
   PubMedGoogle Scholar
• Menozzi D., Gardner J. D., Jensen R. T., Maton P. N. Properties of receptors for gastrin and CCK on gastric smooth muscle cells. Am J Physiol 1989; 257: G73–9
   Google Scholar
• Ihse I., Arnesjö B., Lundquist I. Studies on the reversibility of oral trypsin inhibitor induced changes of rat pancreatic exocrine enzyme activity and insulin secretory capacity. Scand J Gastroenterol 1975; 10: 321–326
   PubMed Web of Science ®Google Scholar
• Ihse I., Lilja P. Effects of intestinal amylase and trypsin on pancreatic secretion in the pig. Scand J Gastroenterol 1979; 14: 1009–13
   PubMed Web of Science ®Google Scholar
• Ihse I., Lilja P., Lundquist I. Feedback regulation of pancreatic enzyme secretion by intestinal trypsin in man. Digestion 1977; 15: 303–8
   PubMed Web of Science ®Google Scholar
• Slaff J. I., Wolfe M. M., Toskes P. P. Elevated fasting cholecystokinin levels in pancreatic exocrine impairment: evidence to support feedback regulation. J Lab Clin Med 1985; 105: 282–5
   PubMed Web of Science ®Google Scholar
• Louie D. S., May D., Miller P., Owyang C. Cholecystokinin mediates feedback regulation of pancreatic enzyme secretion in rats. Am J Physiol 1986; 250: G252–9
   PubMedGoogle Scholar
• Chernick S. S., Leplowsky S., Chaikoff I. L. A dietary factor regulating the enzyme content of the pancreas: changes induced in size and proteolytic activity of the chick pancreas by ingestion of raw soya-bean meal. Am J Physiol 1948; 155: 33–41
   PubMed Web of Science ®Google Scholar
• Arnesjo B., Ihse I., Lundquist I., Qvist L. Effects of exocrine and endocrine rat pancreatic functions of bovine lung trypsin inhibitor administered perorally. Scand J Gastroenterol 1973; 8: 544–54
   Web of Science ®Google Scholar
• Folsch U. R., Winckler K., Wormsley K. G. Effect of a soybean diet on enzyme content and ultrastructure of the rat exocrine pancreas. Digestion 1974; 11: 161–71
   PubMed Web of Science ®Google Scholar
• Miyasaka K., Green G. M. Effect of partial exclusion of pancreatic juice on rat basal pancreatic secretion. Gastroenterology 1984; 86: 114–9
   PubMed Web of Science ®Google Scholar
• Niederau C., Liddle R. A., Williams J. A., Grendell J. H. Pancreatic growth: interaction of exogenous cholecystokinin, a protease inhibitor, and a cholecystokinin receptor antagonist in mice. Gut 1987; 28(Suppl 1)63–9
   PubMedGoogle Scholar
• Dowling R. H., Hosomi M., Stace N. H., et al. Hormones and polyamines in intestinal and pancreatic adaptation. Scand J Gastroenterol 1985; 20(Suppl 112)84–95
   Web of Science ®Google Scholar
• Gasslander T., Axelson J., Hakanson R., et al. Cholecystokinin is responsible for growth of the pancreas following pancreatico-biliary diversion in rats. Scand J Gastroenterol 1990; 25: 1060–5
   PubMed Web of Science ®Google Scholar
• Rothman S. S., Wells H. Enhancement of pancreatic enzyme synthesis by pancreozymin. Am J Physiol 1967; 213: 215–8
   PubMed Web of Science ®Google Scholar
• Barrowman J. A., Mayston P. D. The trophic influence of cholecystokinin on the rat pancreas. J Physiol 1973; 238: 73P–5P
   Web of Science ®Google Scholar
• Ihse I., Arnesjo B., Lundquist I. Effects on exocrine and endocrine rat pancreas of long-term administration of CCK.-PZ (cholecystokinin-pancreozymin) or synthetic octapeptide-CCK.-P. Z. Scand J Gastroenterol 1976; 11: 529–35
   PubMed Web of Science ®Google Scholar
• Anastasi A., Erspamer V., Endean R. Isolation and structure of caerulein, an active decapeptide from the skin of Hyla caerulea. Experientia 1967; 23: 699–700
   PubMedGoogle Scholar
• Solomon T. E., Vanier M., Morisset J. Cell site and time course of DNA synthesis in pancreas after caerulein and secretin. Am J Physiol 1983; 245: G99–105
   PubMedGoogle Scholar
• Dembinski A. B., Johnson L. R. Stimulation of pancreatic growth by secretin, caerulein, and pentagastrin. Endocrinology 1980; 106: 323–8
   PubMed Web of Science ®Google Scholar
• Morisset J., Chamberland S., Gilbert L., Lord A., Larose L. Study of pancreatic DNA synthesis in vivo and in vitro following caerulein treatment in vivo. Biomed Res 1982; 3: 151–8
   Web of Science ®Google Scholar
• Pfeiffer C. J., Chernenko G. A., Kohli Y., Barrowman J. A. Trophic effects of cholecystokinin octapeptide on the pancreas of the Syrian hamster. Can J Physiol Pharmacol 1982; 60: 358–62
   PubMed Web of Science ®Google Scholar
• Johnson L. R. Effect of exogenous gut hormones on gastrointestinal mucosal growth. Scand J Gastroenterol 1982; 17(Suppl 74)89–92
   Google Scholar
• Johnson L. R. Regulation of gastrointestinal growth. Physiology of the gastrointestinal tract, L. R. Johnson. Raven Press, New York 1987; 301–34
   Google Scholar
• Balas D., Senegas-Balas F., Pradayrol L., Vayssette J., Bertrand C., Ribet A. Long-term comparative effect of cholecystokinin and gastrin on mouse stomach, antrum, intestine, and exocrine pancreas. Am J Anat 1985; 174: 27–43
   PubMedGoogle Scholar
• Adler G., Hausmann W., Elsebach K., et al. Effect of pancreatic atrophy and hypertrophy on small intestine. Gut 1987; 28(Suppl 1)193–5
   PubMedGoogle Scholar
• Johnson F. E., LaRegina M. C., Martin S. A., Bashiti H. M. Cholecystokinin inhibits pancreatic and hepatic carcinogenesis. Cancer Detect Prev 1983; 6: 389–402
   PubMedGoogle Scholar
• Andrén-Sandberg A., Dawiskiba S., Ihse I. Studies of the effect of cerulein administration on experimental pancreatic carcinogenesis. Scand J Gastroenterol 1984; 19: 122–8
   PubMed Web of Science ®Google Scholar
• Howatson A. G., Carter D. C. Pancreatic carcinogenesis-enhancement by cholecystokinin in the hamster-nitrosamine model. Br J Cancer 1985; 51: 107–14
   PubMed Web of Science ®Google Scholar
• Meijers M., van Garderen-Hoetmer A., Lamers C. B., Rovati L. C., Jansen J. B., Woutersen R. A. Role of cholecystokinin in the development of BOP-induced pancreatic lesions in hamsters. Carcinogenesis 1990; 11: 2223–6
   PubMed Web of Science ®Google Scholar
• Douglas B. R., Woutersen R. A., Jansen J. B., de Jong A. J., Rovati L. C., Lamers C. B. Influence of cholecystokinin antagonist on the effects of cholecystokinin and bombesin on azaserine-induced lesions in rat pancreas. Gastroenterology 1989; 96: 462–9
   PubMed Web of Science ®Google Scholar
• McGuinness E. E., Morgan R. H G, Wormsley K. G. Fate of pancreatic nodules induced by raw soya flour in rats. Gut 1987; 28(Suppl 1)1207–12
   Google Scholar
• Gumbmann M. R., Dugan G. M., Spangler W. L., Baker E. C., Rackis J. J. Pancreatic response in rats and mice to trypsin inhibitors from soy and potato after short-and long-term dietary exposure. J Nutr 1989; 119: 1598–1609
   PubMed Web of Science ®Google Scholar
• Stace N. H., Palmer T. J., Vaja S., Dowling R. H. Longterm pan-creaticobiliary diversion stimulates hyperplastic and adenomatous nodules in the rat pancreas: a new model for spontaneous tumour formation. Gut 1987; 1(28 Suppl)265–8
   Google Scholar
• Rinderknecht H., Haberfelde G., Maset R., Collias K., Carmack C. Pancreatic secretory abnormalities precede appearance of tumors of the pancreas in hamsters treated with bis-(2-oxo-propyl)-N-nitrosamine. Dig Dis Sci 1983; 28: 526–38
   PubMed Web of Science ®Google Scholar
• Herzig K. H., Creutzfeldt W., Fölsch U. R. Secretagogue response of azaserine-induced rat pancreatic acinar tumors in vivo. Gastroenterology 1991; 101: 220–7
   PubMed Web of Science ®Google Scholar
• Allan B. J., White T. T., Reber H. A., Roberts C., Schilling J. J. Protein secretions in hamsters with pancreatic carcinoma. Dig Dis Sci 1982; 27: 437–43
   PubMed Web of Science ®Google Scholar
• Reber H. A., Johnson F. E., Montgomery C., Carl W. R. Pancreatic secretion in hamsters with pancreatic cancer. Surgery 1977; 82: 34–41
   PubMed Web of Science ®Google Scholar
• Helgeson A. S., Lawson T., Pour P. Exocrine pancreatic secretion in the Syrian golden hamster Mesocricetus auratus. III. Effects of carcinogen administration and development of pancreas cancer. Comp Biochem Physiol ‘C’ 1984; 77: 191–7
   PubMed Web of Science ®Google Scholar
• Warren J. R. Secretagogue response in rat pancreatic acinar carcinoma. J Natl Cancer Inst 1982; 69: 969–74
   PubMedGoogle Scholar
• Carney J. A., Go V. L W, Fairbanks V. F., Moore S. B., Alport E. C., Nora F. E. The syndrome of gastric argyrophil carcinoid tumours and nonantral gastric atrophy. Ann Intern Med 1983; 99: 761–6
   PubMed Web of Science ®Google Scholar
• Hakanson R., Sundler F. Gastric carcinoids and antisecretory drugs. Trends Pharmacol Sci 1986; 6: 386–7
   Google Scholar
• Townsend C. M., Jr, Singh P., Thompson J. C. Effects of gastrointestinal peptides on gastrointestinal cancer growth. Gastroenterol Clin North Am 1989; 18: 777–91
   PubMed Web of Science ®Google Scholar
• Hermanek P. Dysplasia in the gastrointestinal tract: definition and clinical significance. Surg Endosc 1987; 1: 5–10
   PubMedGoogle Scholar
• Harrison J. D., Jones J. A., Morris D. L. The effect of the gastrin, receptor antagonist proglumide on survival in gastric carcinoma. Cancer 1990; 66: 1449–52
   PubMed Web of Science ®Google Scholar
• Chang R. S L, Lotti V. J. Biochemical and pharmacological characterization of an extremely potent and selective non-peptide cholecystokinin antagonist. Proc Natl Acad Sci 1986; 83: 4923–6
   PubMed Web of Science ®Google Scholar
• Evans B. E., Bock M. G., Rittle K. E., et al. Design of potent orally effective, nonpeptidal antagonist of the peptide hormone cholecystokinin. Proc Natl Acad Sci 1986; 83: 4918–22
   PubMed Web of Science ®Google Scholar
• Hosotani R., Chowdhury P., McKay D., Rayford P. L. Effect of L364718, a new CCK antagonist, on amylase secretion in isolated rat pancreatic acini. Pancreas 1988; 3: 95–8
   PubMed Web of Science ®Google Scholar
• Wisner J. R., McLaughlin R. E., Rich K. A., Ozawa S., Renner I. G. Effects of L-364718, a new cholecystokinin receptor antagonist, on camostate-induced growth of the rat pancreas. Gastroenterology 1988; 94: 109–13
   PubMed Web of Science ®Google Scholar
• Sas D. F., Lundy J. K., Miller L. J. Culture of human neoplastic gastrointestinal smooth muscle cells. In Vitro Cell Dev Biol 1989; 25: 730–6
   PubMed Web of Science ®Google Scholar
• Imdahl A., Eggstein S., Crone C., Farthmann E. H. Growth of colorectal carcinoma cells: regulation in vitro by gastrin, pentagastrin and the gastrin-receptor antagonist proglumide. J Cancer Res Clin Oncol 1989; 115: 388–92
   PubMed Web of Science ®Google Scholar
• Hoosein N. M., Kiener P. A., Curry R. C., Brattain M. G. Evidence for autocrine growth stimulation of cultured colon tumor cells by a gastrin/cholecystokinin-like peptide. Exp Cell Res 1990; 186: 15–21
   PubMed Web of Science ®Google Scholar
• Rogy M. A., Koss G., Kovats E., et al. CCK.-8 and gastrin plasma levels in cholecystectomised and colorectal cancer patients. Eur J Surg.
   Google Scholar
• Estival A., Clemente F., Ribet A. Adenocarcinoma of the human exocrine pancreas: presence of secretin and caerulein receptors. Biochem Biophys Res Commun 1981; 102: 1336–41
   PubMed Web of Science ®Google Scholar
• Seva C., Scemama J. L., Basti M. J., Pradayrol L., Vaysse N. Lorglumide and loxiglumide inhibit gastrin-stimulated DNA synthesis in a rat tumoral acinar pancreatic cell line (AR42J). Cancer Res 1990; 50: 5829–33
   PubMed Web of Science ®Google Scholar
• Edwards B. F., Redding T. W., Schally A. V. The effect of gastrointestinal hormones on the incorporation of tritiated thymidine in the pancreatic adenocarcinoma cell line (WD PaCa). Int J Pancreatol 1989; 5: 191–201
   PubMedGoogle Scholar
• Frazier M. L., Pathak S., Wang Z. W., et al. Establishment of a new human pancreatic adenocarcinoma cell line, MDAPanc-3. Pancreas 1990; 5: 8–16
   PubMed Web of Science ®Google Scholar
• Smith J. P., Kramer S., Bagheri S. Effects of a high-fat diet and L364,718 on growth of human pancreas cancer. Dig Dis Sci 1990; 35: 726–32
   PubMed Web of Science ®Google Scholar
• Smith J. P., Kramer S. T., Solomon T. E. CCK stimulates growth of six human pancreatic cancer cell lines in serum-free medium. RegulPept 1991; 32: 341–9
   PubMedGoogle Scholar
• Liehr R. M., Melnykovych G., Solomon T. E. Growth effects of regulatory peptides on human pancreatic cancer lines PANC-1 and MIA PaCa-2. Gastroenterology 1990; 98: 1666–74
   PubMed Web of Science ®Google Scholar
• DiMango E. P., Malagelada J. R., Moertel C. G., Go V. L. Prospective evaluation of the pancreatic secretion of immuno-reactive carcinoembryonic antigen, enzyme, and bicarbonate in patients suspected of having pancreatic cancer. Gastroenterology 1977; 73: 457–61
   PubMed Web of Science ®Google Scholar
• DiMagno E. P., Malagelada J. R., Taylor W. F., Go V. L. A prospective comparison of current diagnostic tests for pancreatic cancer. N Engl J Med 1977; 297: 737–42
   PubMed Web of Science ®Google Scholar
• Rinderknecht H., Renner I. G., Stace N. H. Abnormalities in pancreatic secretory profiles of patients with cancer of the pancreas. Dig Dis Sci 1983; 28: 103–10
   PubMed Web of Science ®Google Scholar
• Lindstedt G., Lundberg P. A., Rolny P. Effect of secretin and cholecystokinin-pancreozymin on plasma CEA concentration in patients with pancreatic carcinoma and pancratitis. Cancer 1979; 43: 2465–70
   PubMed Web of Science ®Google Scholar
• Steffensrud S., Erichsen H., Rosland P., et al. Treatment with secretin and a cholecystokinin-like peptide in patients with pancreatic cancer. A pilot study. Scand J Gastroenterol 1984; 19: 909–15
   PubMed Web of Science ®Google Scholar
• Evers B. M., Gomez G., Townsend C. M., Jr, Rajaraman S., Thompson J. C. Endogenous cholecystokinin regulates growth of human cholangiocarcinoma. Ann Surg 1989; 210: 317–22, discussion 322–3
   PubMed Web of Science ®Google Scholar
• Hudd C., LaRegina M. C., Devine J. E., et al. Response to exogenous cholecystokinin of six human gastrointestinal cancers xeno-grafted in nude mice. Am J Surg 1989; 157: 386–94
   PubMed Web of Science ®Google Scholar
• Beardshall K., Frost G., Morarji Y., Domin J., Bloom S. R., Calam J. Saturation of fat and cholecystokinin release: implications for pancreatic carcinogenesis (see comments). Lancet 1989; 2: 1008–10
   PubMed Web of Science ®Google Scholar
• Douglas B. R., Jansen J. B., de Jong A. J., Lamers C. B. Effect of various triglycerides on plasma cholecystokinin levels in rats. J Nutr 1990; 120: 686–90
   PubMed Web of Science ®Google Scholar
• Rehfeld J. F. Radioimmunoassay in diagnosis, localization and treatment of endocrine tumours in gut and pancreas. Scand J Gastroenterol 1979; 53(Suppl 14)33–8
   Google Scholar
• Woll P. J. Neuropeptide growth factors and cancer. Br J Cancer 1991; 63: 469–75
   PubMed Web of Science ®Google Scholar
• Sundler F., Alumets J., Hakanson R. Majority and minority cell populations in GEP and bronchial endocrine tumours. Scand J Gastroenterol 1979; 53(Suppl 14)9–13
   Google Scholar
• Alumets J., Sundler F., Falkmer S., et al. Neurohormonal peptides in endocrine tumors of the pancreas, stomach, and upper small intestine. I. An immunohistochemical study of 27 cases. Ultrastruct Pathol 1983; 5: 55–72
   PubMed Web of Science ®Google Scholar
• Singh P., Rae-Venter B., Townsend C. M., Jr, Khalil T., Thompson J. C. Gastrin receptors in normal and malignant gastrointestinal mucosa: age-associated changes. Am J Physiol 1985; 249: G761–9
   Google Scholar
• Burke A. P., Federspiel B. H., Sobin L. H., Shekitka K. M., Helwig E. B. Carcinoids of the duodenum. A histologic and immunohistochemical study of 65 tumors. Am J Surg Pathol 1989; 13: 828–37
   PubMed Web of Science ®Google Scholar
• Guarda L. A., Ordonez N. G., del Junco G. W., Luna M. A. Gan-gliocytic paraganglioma of the duodenum: an immunocyto-chemical study. Am J Gastroenterol 1983; 78: 794–8
   PubMed Web of Science ®Google Scholar
• Allen J. M., Hoyle N. R., Yeats J. C., Ghatei M. A., Thomas D. G., Bloom S. R. Neuropeptides in neurological tumours. J Neu-rooncol 1985; 3: 197–202
   PubMed Web of Science ®Google Scholar
• Barrett R. W., Steffey M. E., Wolfram C. A. Type-A cholecystokinin receptors in CHP212 neuroblastoma cells: evidence for association with G protein and activation of phosphoinositide hydrolysis. Mol Pharmacol 1989; 35: 394–400
   PubMed Web of Science ®Google Scholar
• Schneider B. S., Helson L., Monahan J. W., Friedman J. M. Expression of the cholecystokinin gene by cultured human primitive neuroepithelioma cell lines. 1 Clin Endocrinol Metab 1989; 69: 411–9
   PubMed Web of Science ®Google Scholar
• Bardram L., Hilsted L., Rehfeld J. F. Cholecystokinin, gastrin and their precursors in pheochromocytomas. Acta Endocrinol (Copenh) 1989; 120: 479–84
   PubMedGoogle Scholar
• Staley J., Fiskum G., Moody T. W. Cholecystokinin elevates cytosolic calcium in small cell lung cancer cells. Biochem Biophys Res Commun 1989; 163: 605–10
   PubMed Web of Science ®Google Scholar
• Sethi T., Rozengurt E. Multiple neuropeptides stimulate clonal growth of small cell lung cancer: effects of bradykinin, vasopressin, cholecystokinin, galanin, and neurotensin. Cancer Res 1991; 51: 3621–3
   PubMed Web of Science ®Google Scholar
• Sporrong B., Alumets J., Clase L., et al. Neurohormonalpeptide immunoreactive cells in mucinous cystadenomas and cyst-adenocarcinomas of the ovary. Virchows Arch ‘Pathol Anat’ 1981; 392: 271–80
   PubMed Web of Science ®Google Scholar
• Berger G., Fetissof F., Vitrey D., Chayvialle J. A., Feroldi J. Endometrial carcinoma of the intestinal type. A first case report. Appl Pathol 1984; 2: 63–9
   PubMedGoogle Scholar
• Uribe M., Fenoglio-Preiser C. M., Grimes M., Feind C. Medullary carcinoma of the thyroid gland. Clinical, pathological, and immunohistochemical features with review of the literature. Am J Surg Pathol 1985; 9: 577–94
   PubMed Web of Science ®Google Scholar
• Haun R. S., Beinfeld M. C., Roos B. A., Dixon J. E. Establishment of a cholecystokinin-producing rat medullary thyroid carcinoma cell line. Endocrinology 1989; 125: 850–6
   PubMed Web of Science ®Google Scholar
• Poston G. J., Draviam E. J., Seitz P. K., et al. Expression of cholecystokinin forms by medullary thyroid cancer. Int J Cancer 1991; 48: 689–92
   PubMed Web of Science ®Google Scholar
• Telenius-Berg M., Almqvist S., Berg B., et al. Screening for medullary carcinoma of the thyroid in families with Sipple's syndrome: evaluation of new stimulation tests. Eur J Clin Invest 1977; 7: 7–16
   PubMed Web of Science ®Google Scholar
• Persson P., Grunditz T., Axelson J., Sundler F., Håkanson R. Cholecystokinins but not gastrin-17 release calcitonin from thyroid C-cells in the rat. Regul. Pept 1988; 21: 45–56
   PubMedGoogle Scholar