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Original Article

Large-Bowel Mucosal Biotransformation Activity in Persons at High Risk for Colorectal Cancer: A Preliminary Report

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Pages 958-962 | Received 01 Sep 1992, Accepted 05 May 1993, Published online: 08 Jul 2009

References

  • Faber E. Possible etiologic mechanisms in chemical carcinogenesis. Environ Health Perspect 1987; 75: 65–70
  • Rozen P, Horwitz C. Dietary habits and colorectal cancer in rural and urban Israelis. Front Gastroent Res 1988; 14: 209–18
  • Prochaska H J, Delong M, Talalay P. On the mechanisms of induction of cancer-protective enzymes: a unifying proposal. Proc Natl Acad Sci USA 1985; 82: 8232–6
  • Stahlberg M-R, Hietanen E, Maki M. Mucosal biotransformation in the small intestine of children. Gut 1988; 29: 1058–63
  • Wattenberg L W, Leona J L, Strand P J. Benzpyrene hydroxylase activity in the gastrointestinal tract. Cancer Res 1962; 22: 1120–5
  • Kellerman G, Shaw C R, Luyten-Kellerman M. Aryl hydrocarbon hydroxylase inducibility and bronchogenic carcinoma. N Engl J Med 1973; 289: 934–7
  • Paigen B, Gurtoo H L, Minowada J. Questionable relation of aryl hydrocarbon hydroxylase to lung cancer risk. N Engl J Med 1977; 297: 346–50
  • Siegers C-P, Bose-Younes Thies H.E, Hoppenkamps R, Younes M. Glutathione and GSH-dependent enzymes in the tumorous and nontumorous mucosa of the human colon and rectum. J Cancer Res Clin Oncol 1984; 107: 238–41
  • Mekhail-Ishak Hudson K.N, Ming-Sound T, Batist G. Implications for therapy of drug-metabolizing enzymes in human colon cancer. Cancer Res 1989; 49: 4866–9
  • Peters W HM, Nagengast F M, Wobbes T. Glutathione S-trans-ferases in normal and cancerous human colon tissue. Carcinogenesis 1989; 10: 2371–4
  • Peters W HM, Kock L, Nagengast F M, Kremers P G. Biotransformation enzymes in human intestine: critical low levels in the colon?. Gut 1991; 32: 408–12
  • Cassano P, Bonnamoor D, Grolier P. The effect of dietary imbalances on the activation of benzo-a-pyrene by the metabolizing enzymes from the rat liver. Mutat Res 1987; 191: 67–72
  • Hietanen E, Ahotupa M, Bereziat J-C. Monoclonal antibody characterization of hepatic cytochrome P-450 activity in rats treated with phenobarbital or methylcholanthrene and fed various cholesterol diets. Biochem Pharmacol 1987; 36: 3973–80
  • McCarthy D J, Lindamood C, III, Hill D L. Effects of retinoids on metabolizing enzvmes and on binding of benzo-a-pyrene to rat tissue DNA. Cancer Res 1987; 47: 5014–20
  • Nelson D R, Kamataki T, Waxman D J. The P450 super-family: update on new sequences, gene mapping, accession numbers, early trivial names, and nomenclature. DNA Cell Biol 1993; 12: 1–51
  • Gelboin H V. Benzo-a-pyrene metabolism, activation and carcinogenesis: role and regulation of mixed function oxidases and related enzymes. Physiol Rev 1980; 60: 1107–66
  • Gelboin H V. A microsome-dependent binding of benzo-a-pyrene to DNA. Cancer Res 1969; 29: 1272–6
  • Autrup H. Use of explant culture to study the metabolism of polycyclic aromatic hydrocarbons in the human gastrointestinal tract. Adv Physiol Sci 1980; 29: 385–404
  • Autrup H, Harris C C, Stoner G D, Jesudason M L, Trump B F. Binding of chemical carcinogens to macromolecules in cultured human colon. J Natl Cancer Inst 1977; 59: 351–3
  • Lombardi P E, Mayhew J W, Goldin B R. Enzymatic methylation of microsomal metabolites of benzo-a-pyrene. Cancer Res 1981; 41: 4415–9
  • Peters W HM, Kremers P G. Cytochromes P-450 in the intestinal mucosa of man. Biochem Pharmacol 1989; 38: 1535–8
  • Lowry O H, Rosebrough N J, Farr A L, Randall R J. Protein measurement with folin phenol reagent. J Biol Chem 1951; 193: 265–75
  • Depierre J W, Moron M S, Johannesen K AM, Ernster L. A reliable and convenient radioactive assay for benzpyrene mono-oxygenase. Anal Biochem 1975; 63: 470–84
  • Barnea E R, Avigdor S. Aryl hydrocarbon hydroxylase activity in the placenta: induction by carcinogens and chemoprotectors. Obstet Gynecol Invest 1991; 32: 4–9
  • Paul S M, Axelrod J, Deliberto E, Jr. Catechol estrogen-forming enzyme of brain: demonstration of a cytochrome P-450 mono-oxygenase. Endocrinology 1977; 101: 1604–10
  • Barnea E R, Avigdor S. Coordinated induction of estrogen hydroxylase and catechol-O-methyl transferase by xenobiotics in first trimester human placental explants. J Steroid Biochem 1990; 35: 237–331
  • Laitinen M, Watkins J B, III. Mucosal biotransformation. Gastrointestinal toxicology, K Rozman, O Hanninen. Elsevier Science Publishers, Amsterdam 1986; 169–92
  • Huh M MO, Friedhof A J. Multiple molecular forms of catechol-O-methyltransferase. J Biol Chem 1979; 254: 299–308
  • Clifton G, Kaplowitz N. The glutathione S-transferases of small intestine in the rat. Cancer Res 1977; 37: 788–91
  • Idle J R, Mahgoub A, Sloan T P. Some observations on the oxidation phenotype status of Nigerian patients presenting with cancer. Cancer Lett 1981; 11: 331–8
  • Petruzzelli S, Camus A-M, Carrozzi L. Long-lasting effects of tobacco smoking on pulmonary drug-metabolizing enzymes. A case-control study on lung cancer patients. Cancer Res 1988; 48: 4695–700
  • Luk G D, Baylin S B. Inhibition of intestinal epithelial DNA synthesis and adaptive hyperplasia after jejunectomy in the rat by suppression of polyamine biosynthesis. J Clin Invest 1984; 74: 698–704
  • Sugarbaker P H, Macdonald J S, Gundenan J S. Coloretal cancer. Principles of cancer diagnosis and therapy, V De Vita, P H Sugarbaker, S Rosenberg. J. B. Lippincott Co., Philadelphia 1981; 643–723
  • Miller L C, Miller J A. Studies in mechanism of activation of aromatic amines and amides. Ann NY Acad Sci 1969; 103: 731–50
  • Bulovskaya L N, Krupkin R G, Bochina A, Shipkova A A, Pavlova M. Acetylator phenotype in patients with breast cancer. Oncology 1978; 35: 85–188
  • Ilett K F, David B M, Detchon P, Castleden W M, Kwa R. Acetylator phenotype in colorectal carcinoma. Cancer Res 1987; 47: 1466–9
  • Ehrich M, Aswell J E, VanTassell R L, Wilkins T D. Mutagens in the faeces of 3 South African populations at risk for colon cancer. Muta Res 1979; 64: 231–40
  • Peters W HM, Nagengast F M, Van Tongeren J HM. Glutathione S-transferase, cytochrome P450, and uridine 5′-diphosphate-glucuronosyltransferase in human small intestine and liver. Gastroenterology 1989; 96: 783–9
  • Moriya M, Ohta Sugiyama T. F, Miyazawa T, Shirasu Y. Assay for mutagenicity of bile in Sprague Dawley rats treated with intestinal carcinogens. J Natl Cancer Inst 1979; 63: 977–82
  • Mayhew J W, Lombardi P E, Fawaz K. Increased oxidation of a chemical carcinogen, benzo(a)pyrene by colon tissue biopsy specimen from patients with ulcerative colitis. Gastroenterology 1983; 85: 328–34
  • Hein D W. Acetylator genotype and arylamine-induced carcinogenesis. Biochem Biophys Acta 1988; 948: 37–66
  • Marshall C J, Vousden K H, Phillips D M. Activation of C-Ha-ras-1 proto-oncogene by in-vitro modification with a chemical carcinogen, benzo[a]pyrene di-expoxide. Nature 1984; 310: 586–9
  • Fearson E R, Vogelstein B. A genetic model for colorectal tumorgenesis. Cell 1990; 61: 759–67
  • Yuspa S H, Poirier M C. Chemical carcinogenesis: from animal models to molecular models in one decade. Adv Cancer Res 1988; 50: 25–70
  • de Waziers I, Cugnenc P H, Berger A, Leroux J-P, Beaune D H. Drug-metabolizing enzyme expression in human normal, peritumoral and tumoral colorectal tissue samples. Carcinogenesis 1991; 12: 905–9
  • Pero R W, Miller D G, Lipkin M. Reduced capacity for DNA repair in patients with a genetically predisposed colorectal cancer. J Natl Cancer Inst 1983; 70: 867–75
  • Pero R W, Ritchie M, Winawer S J, Markowitz M M, Miller D G. Unscheduled DNA synthesis in mononuclear leukocytes. Cancer Res 1985; 45: 3388–91
  • Markowitz M M, Rozen P, Pero R W, Tobi M, Miller D G. Hydrogen peroxide induced adenosine diphosphate ribosyl transferase (ADPRT) response in patients with inflammatory bowel disease. Gut 1988; 29: 1680–6

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