38
Views
23
CrossRef citations to date
0
Altmetric
Original Article

Treatment of Ulcerative Colitis with High Doses of Oral Prednisolone : The Rate of Remission, the Need for Surgery, and the Effect of Prolonging the Treatment

Pages 821-826 | Received 10 Nov 1992, Accepted 25 Mar 1993, Published online: 08 Jul 2009

References

  • Lennard-Jones J E, Longmore A J, Newell A C, Wilson C WE, Jones F A. An assessment of prednisone, salazopyrin, and topical hydrocortisone hemisuccinate used as out-patient treatment for ulcerative colitis. Gut 1960; 1: 217–22
  • Truelove S C, Witts L J. Cortisone in ulcerative colitis. Final report on a therapeutic trial. Br Med J 1955; 2: 1041–8
  • Lewis G P, Piper P J. Inhibition of release of prostaglandins as an explanation of some of the actions of anti-inflammatory corticosteroids. Nature 1975; 254: 308–11
  • Rugstad H E. Antiinflammatory and immunoregulatory effects of glucocorticoids: mode of action. Scand J Rheumatol 1988; 76(Suppl)257–64
  • Fauci A S, Dale D C, Balow J E. Glucocorticosteroid therapy: mechanisms of action and clinical considerations. Ann Intern Med 1976; 84: 304–15
  • Routes J, Claman H N. Corticosteroids in inflammatory bowel disease. J Clin Gastroenterol 1987; 9: 529–35
  • Lauritsen K, Laursen L S, Bukhave K, Rask-Madsen J. In vivo effects of orally administered prednisolone on prostaglandin and leucotriene production in ulcerative colitis. Gut 1987; 28: 1095–9
  • Lauritsen K, Laursen L S, Bukhave K, Rask-Madsen J. Effects of topical 5-aminosalicylic acid and prednisolone on prostaglandin E2 and leukotriene B4 levels determined by equilibrium in vivo dialysis of rectum in relapsing ulcerative colitis. Gastroenterology 1986; 91: 837–44
  • Fretland D J, Djuric S W, Gaginella T S. Eicosanoids and inflammatory bowel disease: regulation and prospects for therapy. Prostagl Leukotr Essent Fatty Acid 1990; 41: 283–301
  • Sandle G I, Hayslett J P, Binder H J. Effect of glucocorticoids on rectal transport in normal subjects and patients with ulcerative colitis. Gut 1986; 27: 309–16
  • Sandle G I. Segmental variability of glucocorticoid induced electrolyte transport in the rat colon. Gut 1991; 32: 936–40
  • Lennard-Jones J E. Toward optimal use of corticosteroids in inflammatory bowel disease. Gut 1983; 24: 177–81
  • Meyers S, Janowitz H D. Systemic corticosteroid therapy of ulcerative colitis. Gastroenterology 1985; 89: 1189–99
  • Babb R R. Corticosteroids in ulcerative colitis: a skeptical view [editorial]. J Clin Gastroenterol 1988; 10: 365–7
  • Hawkey C J. Acute treatment of inflammatory bowel disease, prednisolone: dosage and duration. Neth J Med 1989; 35: s21–6
  • Kaplan P H, Portnoy B, Binder H J, Amatruda T, Spiro H. A controlled evaluation of intravenous adrenocorticotropic hormone and hydrocortisone in the treatment of acute colitis. Gastroenterology 1975; 69: 91–5
  • Meyers S, Sachar D B, Goldberg J D, Janowitz H D. Corticotropin versus hydrocortisone in the intravenous treatment of ulcerative colitis. A prospective, randomised, double-blind clinical trial. Gastroenterology 1983; 85: 351–7
  • Truelove S C, Jewell D P. Intensive intravenous regimen for severe attacks of ulcerative colitis. Lancet 1974; 1: 1067–70
  • Truelove S C, Willoughby C P, Lee E G, Kettlewell M GW. Further experience in the treatment of severe attacks of ulcerative colitis. Lancet 1978; 2: 1086–8
  • Järnerot G, Rolny P, Sandberg-Gertzén H. Intensive intravenous treatment of ulcerative colitis. Gastroenterology 1985; 89: 1005–13
  • Kristensen M, Koudahl G, Fischerman K, Jarnum S. High dose prednisone treatment in severe ulcerative colitis. Scand J Gastroenterol 1974; 9: 177–83
  • Baron J H, Connell A M, Kanaghinis T G, Lennard-Jones J E, Jones F A. Out-patient treatment of ulcerative colitis. Comparison between three doses of oral prednisone. Br Med J 1962; 2: 441–3
  • Compston J E, Judd D, Crawley E O, et al. Osteoporosis in patients with inflammatory bowel disease. Gut 1987; 28: 410–5
  • Truelove S C, Witts L J. Cortisone and corticotrophin in ulcerative colitis. Br Med J 1959; 1: 387–94
  • Rosenberg W, Ireland A, Jewell D P. High-dose methyl-prednisolon in treatment of active ulcerative colitis. J Clin Gastroenterol 1990; 12: 40–1
  • Milsap R L, George D E, Szefler S J, Murray K A, Lebenthal E, Jusko W J. Effect of inflammatory bowel disease on absorption and disposition of prednisolone. Dig Dis Sci 1983; 282: 161–8
  • Elliott P R, Powell-Tuck J, Gillespie P E, et al. Prednisolone absorption in acute colitis. Gut 1980; 21: 49–51
  • Dearing W H, McGuckin W F, Elveback L R. Serum 0-,-acid glycoprotein in chronic ulcerative colitis. Gastroenterology 1969; 56: 295–303
  • Jensen K B, Jarnum S, Koudahl G, Kristensen M. Serum oro-somucoid in ulcerative colitis. Its relation to clinical activity, protein loss, and turnover of albumin and IgG. Scand J Gastroenterol 1976; 11: 177–83
  • Marner I-L, Friborg S, Simonsen E. Disease activity and serum proteins in ulcerative colitis immunochemical quatitation. Scand J Gastroenterol 1975; 10: 537–44
  • Holdstock G, DuBoulay C E, Smith C L. Survey of the use of colonoscopy in inflammatory bowel disease. Dig Dis Sci 1984; 8: 731–4
  • Lerer P, Meyers S, Feuer E, Johnson J, Janowitz H D. Predicting therapeutic outcomes of severe ulcerative colitis [abstract]. Gastroenterology 1985; 88: 1471

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.