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Original Article

Effect of Glutathione Administration on Hepatic Biliary and Plasmatic Glutathione Levels in the Rat

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Pages 1034-1038 | Received 02 Nov 1993, Accepted 14 Feb 1994, Published online: 08 Jul 2009

References

  • Kosower N D., Kosower E M. The glutathione status of cells. Int Rev Cytol 1978; 54: 104–60
  • Reed D J., Beatty P W. Biosynthesis and regulation of glutathione: toxicological implications. Reviews in biochemical toxicology, E Hodgson, J R. Bend, R M. Philpot. Elsevier, New York 1980; Vol 2: 213–41
  • Kaplowitz N. The physiologic significance of the glutathione-5-transferases. Am J Physiol 1980; 239: 439–44
  • Orrenius S, Jones D P. Functions of glutathione in drug metabolism. Functions of glutathione in liver and kidney, H Sies, A Wendell. Springer, New York 1978; 164–75
  • Jones D P., Moldeus P, Stead A H., Ormstad K, Jornvall H, Orrenius S. Metabolism of glutathione and glutathione conjugate by isolated kidney cells. J Biol Chem 1979; 254: 2787–92
  • Anderson M E., Bridges R J., Meister A. Direct evidence for interorgan transport of glutathione and that the nonfiltration renal mechanism for glutathione utilization involves gamma-glutamyltranspeptidase. Biochem Biophys Res Commun 1980; 96: 848–53
  • Grafstrom R, Stead A H., Orrenius S. Metabolism of extracellular glutathione in rat small-intestinal mucosa. Eur J Biochem 1980; 106: 571–7
  • Hahn R, Wendel A, Flohe L. The fate of extracellular glutathione in the rat. Biochim Biophys Acta 1978; 539: 324–37
  • Inoue M. Interorgan metabolism and membrane transport of glutathione and related compounds. Renal biochemistry, K Rolf, H. J. Kinne. Elsevier, New York 1985; 224–69
  • Meister A. Metabolism and transport of glutathione and other gamma-glutamyl compounds. Functions of glutathione: biochemical, physiological, toxicological and clinical aspects, A Larson, A Holmgren, S Orrenius, B Mannervik. Raven Press, New York 1983; 1–22
  • Speisky H, Gunasekara A, Varghese G, Israel Y. Basolateral gamma-glutamyltransferase ectoactivity in rat liver: effects of chronic alcohol consumption. Alcohol Alcohol 1987; 1(Suppl)245–9
  • Wendel A, Jaeschke H. Drug-induced lipid peroxidation in mice. III. Glutathione content of liver, kidney and spleen after intravenous administration of free and liposomally entrapped glutathione. Biochem Pharmacol 1982; 31: 3607–11
  • Aebi S, Lauterburg B H. Divergent effects of intravenous GSH and cysteine on renal and hepatic GSH. Am J Physiol 1992; 263: R348–52, (Regulatory Integrative Comp Physiol 32)
  • Adams J D., Lauterburg B H., Mitchell J R. Plasma glutathione and glutathione disulfide in the rat: regulation and response to oxidative stress. J Pharmacol Exp Ther 1983; 227: 749–54
  • Kaplowitz N, Eberle D E., Petrini J, Touloukian J, Corvasce M C., Kuhlenkamp J. Factors influencing the efflux of hepatic glutathione in bile in rats. J Pharmacol Exp Ther 1983; 224: 141–7
  • Lauterburg B H., Adams J D., Mitchell J R. Hepatic glutathione homeostasis in the rat: efflux accounts for glutathione turnover. Hepatology 1984; 4: 586–90
  • Reed D J., Babson J R., Beatty B W., Brodie A E., Ellis W W., Potter W. High performance liquid chromatograph analysis of nanomole levels of glutathione, glutathione disulfide, and related thiols and disulfides. Anal Biochem 1980; 106: 55–62
  • Szasz G. A kinetic photometric method for serum gamma-glutamyltranspeptidase. Clin Chem 1969; 15: 124–35
  • Ballatori N, Jacob R, Boyer J L. Intrabiliary glutathione hydrolysis. J Biol Chem 1986; 261: 7860–5
  • Lauterburg B H., Smith C V. Stimulation of hepatic efflux and turnover of glutathione by methionine in the rat. Eur J Clin Invest 1986; 16: 494–9
  • Abbott W A., Bridges R J., Meister A. Extracellular metabolism of glutathione accounts for its disappearance from the basolateral circulation of the kidney. J Biol Chem 1984; 259: 15393–400
  • Watanabe A, Nagashima H. Glutathione metabolism and glucose 6-phosphate dehydrogenase activity in experimental liver injury. Acta Med Okayama 1983; 37: 463–70
  • Speisky H, Shackel N, Varghese G, Wade D, Israel Y. Role of hepatic gamma-glutamyltransferase in the degradation of circulating glutathione: studies in the intact guinea pig perfused liver. Hepatology 1989; 11: 843–9
  • Ballatori N, Clarkson T W. Dependence of biliary secretion of inorganic mercury on the biliary transport of glutathione. Biochem Pharmacol 1984; 33: 1093–8
  • Lauterburg B H., Smith C V., Hughes H, Mitchell J R. Biliary excretion of glutathione and glutathione disulfide in the rat. J Clin Invest 1984; 73: 124–33
  • Vendemiale G, Altomare E, Lieber C S. Altered biliary excretion of acetaminophen in rats fed ethanol chronically. Drug Metab Dispos 1984; 12: 20–4
  • Vendemiale G, Jayatilleke E, Shaw S, Lieber C S. Depression of biliary glutathione excretion by chronic ethanol feeding in the rat. Life Sci 1984; 34: 1065–73
  • Ballatori N, Truong A T. Relation between biliary glutathione excretion and bile acid-independent bile flow. Am J Physiol 1989; 256: G22–30, (Gastrointest Liver Physiol 19)
  • Lash L H., Hagen T M., Jones D P. Exogenous glutathione protects intestinal epithelial cells from oxidative injury. Proc Natl Acad Sci USA 1986; 83: 4641–5
  • Martensson J, Jain A, Meister A. Glutathione is required for intestinal function. Proc Natl Acad Sci USA 1990; 87: 1715–9
  • Hagen T M., Jones D P. Transepithelial transport of glutathione in vascularly perfused small intestine of rat. Am J Physiol 1987; 252: G607–13, (Gastrointest Liver Physiol 15)
  • Sastre J, Pallardo F V., Llopis J, Furukawa T, Vina J R., Vina J. Glutathione depletion by hyperphagia-induced obesity. Life Sci 1989; 45: 183–7

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