8
Views
2
CrossRef citations to date
0
Altmetric
Original Article

Dissolution of Human Cholesterol Gallstones in Bile Salt/Lecithin Mixtures: Effect of Bile Salt Hydrophobicity and Various pHs

, , , &
Pages 1178-1185 | Received 17 Nov 1994, Accepted 31 Mar 1995, Published online: 08 Jul 2009

References

  • Sauerbruch T, Paumgartner G. Gallbladder stones: management. Lancet 1991; 338: 11214
  • Dissolving hopes for gallstone dissolution. Lancet 1981; 2: 905–6, [editorial].
  • Hofmann A F, Mysels IU. Bile acid solubility and precipitation in vitro and in vivo: the role of conjugation, pH, and Ca2+ ions. J Lipid Res 1992; 33: 617–26
  • Angelico M, Della Guardia P, Baiocchi L, Nistri A, Castaldo P, Ginanni Corradini S, et al. Cholesterol crystal onset and growth kinetics in gallbladder bile after administration of tauroursodeoxycholic and ursodeoxycholic acid in man. J Hepatol 1993; 18: S90, Suppl 1
  • Salvioli G, Igimi H, Carey MC. Cholesterol gallstone dissolution in bile. Dissolution kinetics of crystallin cholesterol monohydrate by conjugated chenodeoxycholate/lecithin and conjugated ursodeoxycholate/lecithin mixtures: dissimilar phase equilibria and dissolution mechanisms. J Lipid Res 1983; 24: 701–20
  • Angelico M, Avella A. Nuovi sali biliari all'orizzonte nella terapia medica della calcolosi biliare. Epatologia 1988; 34: 151–9
  • Pope JL. Crystallization of sodium taurocholate. J Lipid Res 1967; 8: 146–7
  • Eneroth P. Thin layer chromatography of bile acids. J Lipid Res 1966; 4: 11–6
  • Cantafora A, Di Biase A, Alvaro D, Angelico M. Improved method for measuring the glycine and taurine conjugates of bile salts by high-performance liquid chromatography with tauro-7-alpha, 12alpha dihydroxy-5-beta-cholanic acid as internal standard. J Chromatography 1987; 386: 367–70
  • Carey M C, Small DM. The physical-chemistry of cholesterol solubility in bile. Relationship to gallstone formation and dissolution in man. J Clin Invest 1978; 61: 998–1026
  • Carey MC. Critical tables for calculating the cholesterol saturation of native bile. J Lipid Res 1978; 19: 945–55
  • Seidel J, Hagele E O, Ziegenhorn J. Reagents for the enzymatic determination of serum total cholesterol with improved lipolytic efficiency. Clin Chem 1983; 29: 1075–980
  • Heuman D M, Hylemon P B, Vlahcevic ZR. Regulation of bile acid synthesis III. Correlation between biliary bile salt hydrophobicity index and the activities of the enzymes regulating cholesterol and bile acid synthesis in the rat. J Lipid Res 1989; 30: 1161–71
  • Thistle J L, Hofmann A F, Ott B J, Stephens DH. Chenotherapy for gallstone dissolution I. Efficacy and safety. JAMA 1978; 239: 1041–6
  • Ward A, Brodgen R N, Heel R C, Speight T M, Avery GS. Ursodeoxycholic acid. A review of its pharmacological properties and therapeutic efficacy. Drugs 1984; 27: 95–131
  • Podda M, Zuin M, Battezzati P M, Ghezzi C, De Fazio C, Dioguardi ML. Efficacy and safety of a combination of chenodeoxycholic acid and ursodeoxycholic acid for gallstone dissolution: a comparison with ursodeoxycholic acid alone. Gastroenterology 1989; 96: 222–9
  • Hardison W GM, Grundy SM. Effect of ursodeoxycholate and its taurine conjugate on bile acid synthesis and cholesterol absorption. Gastroenterology 1984; 87: 130–5
  • Go W. LW Poley, Hofmann J. R., Summerskill A. F., Hj W. Disturbances of fat digestion induced by acid jejunal pH due to gastric hypersecretion in man. Gastroenterology 1970; 58: 638–64
  • Rege R V, Moore EW. Evidence of H+ secretion by the in vivo canine gallbladder. Gastroenterology 1987; 92: 281–9
  • Ostrow J D, Celic L. Apparent solubility products (K'sp) of the calcium salts of unconjugated bilirubin indicate supersaturation of human gallbladder bile with Ca(HB)2, but not CaB. Hepatology 1987; 7: 1111, [abstract]
  • Smith B F, Ja Peetermans, Tanaka T, LaMont JT. Subunit interactions and physical properties of bovine gallbladder mucin. Gastroenterology 1989; 97: 179–87
  • Smith B F, LaMont JT. Identification of gallbladder mucin-bilirubin complex in human cholesterol gallstone matrix. Effects of reducing agents on in vitro dissolution of matrix and intact stones. J Clin Invest 1985; 76: 439–45
  • Freilich H S, Malet P F, Schwartz J S, Soloway RD. Chemical and morphologic characteristics of cholesterol gallstones that failed to dissolve on chenodiol. Gastroenterology 1986; 91: 713–8
  • Fromm H, Roat J W, Gonzales V, Sarva R P, Farivar S. Comparative efficacy and side effects of ursodeoxycholic and chenodeoxycholic acids in dissolving gallstones. Gastroenterology 1983; 85: 1257–64
  • Carulli N, Ponz de Leon M, Loria P, Iori R, Rosi A, Romani M. Effect of selective expansion of cholic acid pool on bile lipid composition: possible mechanism of bile acid-induced cholesterol desaturation. Gastroenterology 1981; 81: 539–46
  • McSherry C K, Mosbach E H, Cohen B I, Une M, Stenger R J, Singhal AK. Hyodeoxycholic acid: a new approach to gallstone prevention. Am J Surgery 1985; 149: 126–32
  • Singhal A K, Cohen B I, Finver-Sadowsky J, McSherry C K, Mosbach EH. Role of hydrophilic bile acids and of sterols on cholelithiasis in the hamster. J Lipid Res 1984; 25: 564–70
  • Cohen B I, Mosbach E W, McSherry C K, Stenger R J, Kuroki S, Rzigalinski B. Gallstone prevention in prairie dogs: comparison of chow vs semisynthetic diets. Hepatology 1986; 6: 874–80
  • Saquet E, Parquet M, Riottot M, Raizman A, Jarrige A, Huguet C, et al. Intestinal absorption, excretion, and biotransformation of hyodeoxycholic acid in man. J Lipid Res 1983; 24: 604–13
  • Angelico M, Baiocchi L, Nistri A, Franchitto A, Della Guardia P, Gaudio E. Taurohyodeoxycholic acid, a hydrophilic bile salt with novel physical-chemical and biliary secretory properties in the rat. Dig Dis Sci 1994; 39: 2389–97
  • Bozzoli M, Loria P, Angelico M, Bertolotti M, Carubbi F, Concari M, et al. Effect of taurohyodeoxycholic acid on biliary lipid secretion in man. Hepatology 1993; 18(Pt 2)308A
  • Corrigan O I, Su C C, Higuchi W I, Hofmann AF. Mesophase formation during cholesterol dissolution in ursodeoxycholate-lecithin solutions: new mechanisms for gallstone dissolution in humans. J Pharm Sci 1980; 69: 869–70
  • Niu N, Smith BF. Addition of N-acetylcysteine to aqueous model bile systems accelerates dissolution of cholesterol gallstones. Gastroenterology 1990; 98: 454–63
  • Sauerbruch T, Delius B, Paumgartner, Holl J, Wess O, Weber W, et al. Fragmentation of gallstone by extracorporeal shock waves. N Engl J Med 1986; 314: 818–22
  • Linsdale K. Epitaxy as a growth factor in urinary and gallstones. Nature 1967; 217: 56–8
  • Shiffman M L, Sugerman H J, Moore EW. Human gallbladder mucosal function. Effect of concentration and acidification of bile on cholesterol and calcium solubility. Gastroenterology 1990; 99: 1452–9
  • Brodersen R. Bilirubin. Solubility and interaction with albumin and phospholipid. J Biol Chem 1979; 254: 2364–9
  • Massari S, Folena E, Ambrosin V, Schiavo G, Colonna R. pH-dependent lipid packing, membrane permeability and fusion in phosphatidylcholine vesicles. Biochim Biophys Acta 1991; 1067: 131–8
  • Jacobsohn M K, Bazilian L S, Hardiman J, Jacobsohn GM. Effect of pH on the affinity of phospholipids for cholesterol. Lipids 1989; 24: 375–82
  • Magnuson T H, Lillemoe K D, Zarkin B A, Pitt HA. Patients with uncomplicated cholelithiasis acidify bile normally. Dig Dis Sci 1992; 37: 1517–22

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.