Recent increase in enterococci, viridans streptococci, Pseudomonas spp. and multiresistant strains among haematological patients, with a negative impact on outcome. Results of a 3-year surveillance study at a single institution

References

• Oppenheim BA. The changing pattern of infection in neutropenic patients. J Antimicrob Chemother 1998;41(Suppl D):7–11.
   PubMed Web of Science ®Google Scholar
• Gaytan-Martinez J, Mateos-Garcia E, Sanchez-Cortes E, Gonzalez-Llaven J, Casanova-Cardiel LJ, Fuentes-Allen JL. Microbiological findings in febrile neutropenia. Arch Med Res 2000;31:388–92.
   PubMed Web of Science ®Google Scholar
• Zaas AK, Song X, Tucker P, Perl TM. Risk factors for development of vancomycin-resistant enterococcal bloodstream infection in patients with cancer who are colonized with vancomycin-resistant enterococci. Clin Infect Dis 2002;35:1139–46.
   PubMed Web of Science ®Google Scholar
• Harris AD, Samore MH, Lipsitch M, Kaye KS, Perencevich E, Carmeli Y. Control-group selection importance in studies of antimicrobial resistance: examples applied to Pseudomonas aeruginosa, enterococci, and Escherichia coli. Clin Infect Dis 2002;34:1558–63.
   PubMed Web of Science ®Google Scholar
• Ohmagari N, Hanna H, Graviss L, Hackett B, Perego C, Gonzalez V, . Risk factors for infections with multidrug-resistant Pseudomonas aeruginosa in patients with cancer. Cancer 2005;104:205–12.
   PubMed Web of Science ®Google Scholar
• Kern WV, Klose K, Jellen-Ritter AS, Oethinger M, Bohnert J, Kern P, . Fluoroquinolone resistance of Escherichia coli at a cancer center: epidemiologic evaluation and effects of discontinuing prophylactic fluoroquinolone use in neutropenic patients with leukaemia. Eur J Clin Microbiol Infect Dis 2005;24:111–8.
   PubMed Web of Science ®Google Scholar
• Viscoli C, Castagnola E. Treatment of febrile neutropenia: what is new? Curr Opin Infect Dis 2002;15:377–82.
   PubMed Web of Science ®Google Scholar
• Cattaneo C, Quaresmini G, Casari S, Capucci MA, Micheletti M, Brolenghi E, . Recent changes in bacterial epidemiology and the emergence of fluoroquinolone-resistant Escherichia coli among patients with haematological malignancies: result of a prospective study on 823 patients at a single institution. J Antimicrob Chemother 2008;61:721–8.
   PubMed Web of Science ®Google Scholar
• Micol JB, de Botton S, Guieze R, Coiteux V, Darre S, Dessein R, . An 18-case outbreak of drug-resistant Pseudomonas aeruginosa bacteraemia in haematology patients. Haematologica 2006;91:1134–8.
   PubMed Web of Science ®Google Scholar
• Worth LJ, Thursky KA, Seymour JF, Slavin MA. Vancomycin-resistant Enterococcus faecium infection in patients with hematologic malignancy: patients with acute myeloid leukaemia are at high risk. Eur J Haematol 2007;79:226–33.
   PubMed Web of Science ®Google Scholar
• Bach PB, Malak SF, Jurcic J, Gelfand SE, Eagan J, Little C, . Impact of infection by vancomycin-resistant Enterococcus on survival and resource utilization for patients with leukaemia. Infect Control Hosp Epidemiol 2004;25:391–4.
   PubMed Web of Science ®Google Scholar
• Hachem RY, Chemaly RF, Ahmar CA, Jiang Y, Boktour MR, Rjaili GA, . Colistin is effective in treatment of infections caused by multidrug-resistant Pseudomonas aeruginosa in cancer patients. Antimicrob Agents Chemother 2007;51:1905–11.
   PubMed Web of Science ®Google Scholar
• Hughes WT, Armstrong D, Bodey GP, Bow EJ, Brown AE, Calandra T, . 2002 Guidelines for the use of antimicrobial agents in neutropenic patients with cancer. Clin Infect Dis 2002;34:730–51.
   PubMed Web of Science ®Google Scholar
• O'Grady NP, Alexander M, Dellinger EP, Gerberding JL, Heard SO, Maki DG, . Guidelines for the prevention of intravascular catheter-related infections. Clin Infect Dis 2002;35:1281–307.
   Web of Science ®Google Scholar
• Bauer KW, Kirby WM, Sherris JC, Turck M. Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol 1966;45:493–6.
   PubMed Web of Science ®Google Scholar
• Paterson DL. The epidemiological profile of infections with multidrug-resistant Pseudomonas aeruginosa and Acinetobacter species. Clin Infect Dis 2006;43:S43–8.
   PubMed Web of Science ®Google Scholar
• Kern WV, Andriof E, Oethinger M, Kern P, Hacker J, Marre R. Emergence of fluoroquinolone-resistant Escherichia coli at a cancer center. Antimicrob Agents Chemother 1994;38:681–7.
   PubMed Web of Science ®Google Scholar
• Peterson LR. Squeezing the antibiotic balloon: the impact of antimicrobial classes on emerging resistance. Clin Microbiol Infect 2005;11:4–16.
   PubMed Web of Science ®Google Scholar
• Velasco E, Byington R, Martins CA, Schirmer M, Dias LM, Goncalves VM. Comparative study of clinical characteristics of neutropenic and non-neutropenic adult cancer patients with bloodstream infections. Eur J Clin Microbiol Infect Dis 2006;25:1–7.
   PubMed Web of Science ®Google Scholar
• Brunet AS, Ploton C, Galambrun C, Pondarré C, Pages MP, Bleyzac N, . Low incidence of sepsis due to viridans streptococci in a ten-year retrospective study of pediatric acute myeloid leukaemia. Pediatr Blood Cancer 2006;47:765–72.
   PubMed Web of Science ®Google Scholar
• Razonable RR, Litzow MR, Khaliq Y, Piper KE, Rouse MS, Patel R. Bacteremia due to viridans group streptococci with diminished susceptibility to levofloxacin among neutropenic patients receiving levofloxacin prophylaxis. Clin Infect Dis 2002;34:1469–74.
   PubMed Web of Science ®Google Scholar
• Marron A, Carratala J, Gonzalez-Barca E, Fernandez-Sevilla A, Alcaide F, Gudiol F. Serious complications of bacteremia caused by viridans streptococci in neutropenic patients with cancer. Clin Infect Dis 2000;31:1126–30.
   PubMed Web of Science ®Google Scholar
• Todeschini G, Tecchio C, Borghero C, D'Emilio A, Pegoraro E, de Lalla F, . Association between Enterococcus bacteraemia and death in neutropenic patients with haematological malignancies. J Infect 2006;53:266–73.
   PubMed Web of Science ®Google Scholar
• Ramphal R. Changes in the etiology of bacteremia in febrile neutropenic patients and the susceptibilities of the currently isolated pathogens. Clin Infect Dis 2004;39(Suppl 1):25–31.
   PubMed Web of Science ®Google Scholar
• Gillespie TA, Johnson PR, Notman AW, Coia JE, Hanson MF. Eradication of a resistant Pseudomonas aeruginosa strain after a cluster of infections in a hematology/oncology unit. Clin Microbiol Infect 2000;6:125–30.
   PubMed Web of Science ®Google Scholar
• Pagano L, Caira M, Candoni A, Offidani M, Fianchi L, Martino B, . The epidemiology of fungal infections in patients with hematological malignancies: the SEIFEM-2004 study. Haematologica 2006;91:1068–75.
   PubMed Web of Science ®Google Scholar