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Scandinavian Journal of Urology and Nephrology Volume 23, 1989 - Issue 3
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Original Article

LHRH Analogue as a Depot Preparation (Zoladex) in the Treatment of Advanced Carcinoma of the Prostate Followed by Orchiectomy as a Second Line Therapy—A Phase II Study

Peter Iversen Department of Urology, Hvidovre Hospital, Hvidovre
,
Carsten Rose the Department of Oncology, Finsen Institute, Copenhagen, Denmark
,
Jens Georg Stage Department of Urology, Bispebjerg Hospital, Copenhagen, Denmark
,
Hans-Georg Iversen Department of Urology, Hvidovre Hospital, Hvidovre
,
Rolf Iversen Hansen Department of Urology, Hvidovre Hospital, Hvidovre
,
Valdemar Hvidt Department of Urology, Bispebjerg Hospital, Copenhagen, Denmark
,
Peter Mogensen Department of Urology, Bispebjerg Hospital, Copenhagen, Denmark
,
Torben Pedersen Department of Surgery, Frederiksberg Hospital, Copenhagen, Denmark
&
Jørgen Bech Hansen Department of Surgery, Frederiksberg Hospital, Copenhagen, Denmark
 show all
Pages 177-183 | Received 30 Jun 1988, Published online: 15 Feb 2010

REFERENCES

  • Ahmed SR, Brooman PJC, Shalet SM, Howell A, Blacklock NJ, Rickards D. Treatment of advanced prostatic cancer with LHRH analogue ICI 118630: Clinical response and hormonal mechanisms. Lancet 1983; 2: 415–419.
  • Ahmed SR, Grant J, Shalet SM et al. Preliminary report on use of depot formulation of LHRH analogue ICI 118630 (Zoladex) in patients with prostatic cancer. Br Med J 1985; 290: 185–187.
  • Byar D. The Veterans Administration Co-operative Urological Research Group's studies of cancer of the prostate. Cancer 1973; 32: 1126–1130.
  • Coy DH, Schally AV. Gonadotrophin releasing hormone analogues. Ann Clin Res 1978; 10: 139–144.
  • Emtage LA, Perren TJ, Stuart NSA et al. Phase II study of Zoladex depot in advanced prostatic cancer with special reference to criteria of response and survival. Br J Urol 1987; 60: 436–442.
  • Furr BJA, Hutchinson FG. Biodegrabale sustained release formulation of the LH-RH analogue “Zoladex” for the treatment of hormone-responsive tumours. In: Schroeder FH, ed. EORTC Genitourinary Group Monograph 2, Part A: Therapeutic principles in metastatic prostatic cancer. New York: Alan R. Liss, 1985; 143.
  • Huggins C, Hodges CV. Studies on prostatic cancer. I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. Cancer Res 1941; 1: 293–297.
  • Labrie F, Dupont A, Belanger A, Lachanche R. Flutamide eliminates the risk of disease flare in prostatic cancer patients treated with a luteinizing hormone-releasing hormone agonist. J Urol 1987; 138: 804–806.
  • Parmar H, Edwards L, Phillips RH, Allen L, Lightman SL. Orchiectomy versus long-acting D-trp-6-LHRH in advanced prostatic cancer. Br J Urol 1987; 59: 248–254.
  • The Veterans Administration Co-operative Urological Research Group.: Treatment and survival of patients with cancer of the prostate. Surg Gynecol Obstet 1967; 124: 1011–1017.
  • SmithJr JA. Androgen suppression by a gonadotropin releasing hormone analogue in patients with metastatic carcinoma of the prostate. J Urol 1984; 131: 1110–1112.
  • SmithJr JA, Urry RL. Testicular histology after prolonged treatment with a gonadotropin-releasing hormone analogue. J Urol 1985; 133: 612–614.
  • Waxman J, Man A, Hendry WF et al. Importance of early tumour exacerbation in patients treated with long acting analogues of gonadotropin releasing hormone for advanced prostatic cancer. Br Med J 1985; 291: 1387–1388.

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