Cross-species comparisons of the pharmacokinetics of ibudilast

References

• Agrawal AK, Shapiro BH. (2003). Constitutive and inducible hepatic cytochrome P450 isoforms in senescent male and female rats and response to low-dose phenobarbital. Drug Metab Disposit 31:612–19.
   PubMed Web of Science ®Google Scholar
• Ayrton A, Morgan P. (2001). Role of transport proteins in drug absorption, distribution and excretion. Xenobiotica 31:469–97.
   PubMed Web of Science ®Google Scholar
• Bergheim I, Bode C, Parlesak A. (2005). Distribution of cytochrome P450 2C, 2E1, 3A4, and 3A5 in human colon mucosa. BMC Clin Pharmacol 5:4.
   PubMedGoogle Scholar
• Bleasby K, Castle JC, Roberts CJ, Cheng C, Bailey WJ, Sina JF, Kulkarni AV, Hafey MJ, Evers R, Johnson JM, Ulrich RG, Slatter JG. (2006). Expression profiles of 50 xenobiotic transporter genes in humans and pre-clinical species: a resource for investigations into drug disposition. Xenobiotica 36:963–88.
   PubMed Web of Science ®Google Scholar
• Burchell B, Coughtrie MW. (1989). UDP-glucuronosyltransferases. Pharmacol Ther 43:261–89.
   PubMed Web of Science ®Google Scholar
• Cao X, Gibbs ST, Fang L, Miller HA, Landowski CP, Shin HC, Lennernas H, Zhong Y, Amidon GL, Yu LX, Sun D. (2006). Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model. Pharmaceut Res 23:1675–86.
   PubMed Web of Science ®Google Scholar
• Collier AC, Tingle MD, Keelan JA, Paxton JW, Mitchell MD. (2000). A highly sensitive fluorescent microplate method for the determination of UDP-glucuronosyl transferase activity in tissues and placental cell lines. Drug Metab Disposit 28:1184–6.
   PubMed Web of Science ®Google Scholar
• Davies B, Morris T. (1993). Physiological parameters in laboratory animals and humans. Pharmaceut Res 10:1093–5.
   PubMed Web of Science ®Google Scholar
• Ding X, Kaminsky LS. (2003). Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts. Ann Rev Pharmacol Toxicol 43:149–73.
   PubMed Web of Science ®Google Scholar
• Kawanokuchi J, Mizuno T, Kato H, Mitsuma N, Suzumura A. (2004). Effects of interferon-beta on microglial functions as inflammatory and antigen presenting cells in the central nervous system. Neuropharmacology 46:734–42.
   PubMed Web of Science ®Google Scholar
• Kishi Y, Ohta S, Kasuya N, Sakita S, Ashikaga T, Isobe M. (2001). Ibudilast: a non-selective PDE inhibitor with multiple actions on blood cells and the vascular wall. Cardiovasc Drug Rev 19:215–25.
   PubMed Web of Science ®Google Scholar
• Ledeboer A, Hutchinson MR, Watkins LR, Johnson KW. (2007). Ibudilast (AV-411). A new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes. Exp Opin Investig Drug 16:935–50.
   PubMed Web of Science ®Google Scholar
• Ledeboer A, Liu T, Shumilla JA, Mahoney JH, Vijay S, Gross MI, Vargus JA, Sultzbaugh L, Claypool MD, Sanftner LM, Watkins LR, Johnson KW. (2006). The glial modulatory drug AV411 attenuates mechanical allodynia in rat models of neuropathic pain. Neuron Glia Biol 2:279–91.
   PubMedGoogle Scholar
• Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. (1951). Protein measurement with the Folin phenol reagent. J Biol Chem 193:265–75.
   PubMed Web of Science ®Google Scholar
• Lu C, Li AP. (2001). Species comparison in P450 induction: effects of dexamethasone, omeprazole, and rifampin on P450 isoforms 1A and 3A in primary cultured hepatocytes from man, Sprague–Dawley rat, minipig, and beagle dog. Chem-Biol Interact 134:271–81.
   PubMed Web of Science ®Google Scholar
• Maeda S, Ishida R, Komuro M, Ohmuro S, Hashimoto H, Hotta M, Uchida H. (1989). Studies of KC-404 (3-isobutyryl-2-isopopylpyrazolo-[1,5-apyridine) pharmacokinetics in humans (Report 2). Kiso to Rinsho 23:183–9. [in Japanese]
   Google Scholar
• Marchand F, Perretti M, McMahon SB. (2005). Role of the immune system in chronic pain. Nat Rev Neurosci 6:521–32.
   PubMed Web of Science ®Google Scholar
• Martignoni M, Groothuis GM, de Kanter R. (2006). Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction. Exp Opin Drug Metab Toxicol 2:875–94.
   PubMed Web of Science ®Google Scholar
• Matsubara T, Koike M, Touchi A, Tochino Y, Sugeno K. (1976). Quantitative determination of cytochrome P-450 in rat liver homogenate. Ann Biochem 75:596–603.
   Google Scholar
• McGinnity DF, Collington J, Austin RP, Riley RJ. (2007). Evaluation of human pharmacokinetics, therapeutic dose and exposure predictions using marketed oral drugs. Curr Drug Metab 8:463–79.
   PubMed Web of Science ®Google Scholar
• Mizuno T, Kurotani T, Komatsu Y, Kawanokuchi J, Kato H, Mitsuma N, Suzumura A. (2004). Neuroprotective role of phosphodiesterase inhibitor ibudilast on neuronal cell death induced by activated microglia. Neuropharmacology 46:404–11.
   PubMed Web of Science ®Google Scholar
• Moalem G, Tracey DJ. (2006). Immune and inflammatory mechanisms in neuropathic pain. Brain Res Rev 51:240–264.
   PubMed Web of Science ®Google Scholar
• Nagatsu Y, Higuchi T, Hirobe M. (1990). Application of chemical P-450 model systems to study drug metabolism. III. Metabolism of 3-isobutyryl-2-isopropylpyrazolo[1,5-alpha]pyridine. Chem Pharmacol Bull (Tokyo) 38:400–3.
   PubMed Web of Science ®Google Scholar
• Ohe T, Sato M, Tanaka S, Fujino N, Hata M, Shibata Y, Kanatani A, Fukami T, Yamazaki M, Chiba M, Ishii Y. (2003). Effect of P-glycoprotein-mediated efflux on cerebrospinal fluid/plasma concentration ratio. Drug Metab Disposit 31:1251–4.
   PubMed Web of Science ®Google Scholar
• Peterson GL. (1979). Review of the Folin phenol protein quantitation method of Lowry, Rosebrough, Farr and Randall. Ann Biochem 100:201–20.
   Google Scholar
• Plopper CG, Weir AJ, Morin D, Chang A, Philpot RM, Buckpitt AR. (1993). Postnatal changes in the expression and distribution of pulmonary cytochrome P450 monooxygenases during Clara cell differentiation in rabbits. Mol Pharmacol 44:51–61.
   PubMedGoogle Scholar
• Pustylnyak VP, Lebedev AN, Gulyaeva LF, Lyakhovich VV, Slynko NM. (2007). Comparative study of CYP2B induction in the liver of rats and mice by different compounds. Life Sci 80:324–8.
   PubMed Web of Science ®Google Scholar
• Rolan P, Gibbons JA, He L, Chang E, Jones D, Gross MI, Davidson JB, Sanftner LM, Johnson KW. (2008). Ibudilast in healthy volunteers: safety, tolerability and pharmacokinetics with single and multiple doses. Br J Clin Pharmacol 66:792–801.
   PubMed Web of Science ®Google Scholar
• Schuetz EG, Schuetz JD, May B, Guzelian PS. (1990). Regulation of cytochrome P-450b/e and P-450p gene expression by growth hormone in adult rat hepatocytes cultured on a reconstituted basement membrane. J Biol Chem 265:1188–92.
   PubMed Web of Science ®Google Scholar
• Sonderfan AJ, Arlotto MP, Dutton DR, McMillen SK, Parkinson A. (1987). Regulation of testosterone hydroxylation by rat liver microsomal cytochrome P-450. Arch Biochem Biophys 255:27–41.
   PubMed Web of Science ®Google Scholar
• Suzumura A, Ito A, Yoshikawa M, Sawada M. (1999). Ibudilast suppresses TNFalpha production by glial cells functioning mainly as type III phosphodiesterase inhibitor in the CNS. Brain Res 837:203–12.
   PubMed Web of Science ®Google Scholar
• Takagi KEK, Nagatsu Y. (1985). Studies on the metabolic fate of 3-isobutyryl-2-isopropyl yrazolo(1,5-a) pyridine (KC-404). 1. Absorption, distribution and excretion in rats, dogs, and monkeys. Oyo Yakuri 30:967–81.
   Google Scholar
• Uchida O, Ohmuro S, Hashimoto H, Irikura T. (1985). Pharmacokinetics and metabolism of 3-isobutyryl-2-isopropylpyrazolo [1,5-a]pyridine (KC-404) in humans. Kiso to Rinsho 19:42–50. [in Japanese]
   Google Scholar
• Ullrich D, Bock KW. (1984). Glucuronide formation of various drugs in liver microsomes and in isolated hepatocytes from phenobarbital- and 3-methylcholanthrene-treated rats. Biochem Pharmacol 33:97–101.
   PubMed Web of Science ®Google Scholar
• Watkins LR, Hutchinson MR, Johnston IN, Maier SF. (2005). Glia: novel counter-regulators of opioid analgesia. Trend Neurosci 28:661–9.
   PubMed Web of Science ®Google Scholar
• Watkins LR, Hutchinson MR, Ledeboer A, Wieseler-Frank J, Milligan ED, Maier SF. (2007). Norman Cousins Lecture. Glia as the ‘bad guys’: implications for improving clinical pain control and the clinical utility of opioids. Brain Behav Immunit 21:131–46.
   PubMed Web of Science ®Google Scholar
• Watkins LR, Maier SF. (2003). Glia: a novel drug discovery target for clinical pain. Nat Rev Drug Disc 2:973–85.
   PubMed Web of Science ®Google Scholar
• Winsnes A. (1969). Studies on the activation in vitro of glucuronyltransferase. Biochim Biophys Acta 191:279–91.
   PubMed Web of Science ®Google Scholar
• Yamada H, Ishii Y, Yamamoto M, Oguri K. (2006). Induction of the hepatic cytochrome P450 2B subfamily by xenobiotics: research history, evolutionary aspect, relation to tumorigenesis, and mechanism. Curr Drug Metab 7:397–409.
   PubMed Web of Science ®Google Scholar
• Yamazoe Y, Shimada M, Murayama N, Kato R. (1987). Suppression of levels of phenobarbital-inducible rat liver cytochrome P-450 by pituitary hormone. J Biol Chem 262:7423–8.
   PubMed Web of Science ®Google Scholar
• Zhang QY, Dunbar D, Ostrowska A, Zeisloft S, Yang J, Kaminsky LS. (1999). Characterization of human small intestinal cytochromes P-450. Drug Metab Disposit 27:80409.
   Google Scholar