Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 40, 2010 - Issue 5
176
Views
17
CrossRef citations to date
0
Altmetric
Animal Pharmacokinetics and Metabolism

Pharmacokinetic/pharmacodynamic modelling of 2-acetyl-4(5)-tetrahydroxybutyl imidazole-induced peripheral lymphocyte sequestration through increasing lymphoid sphingosine 1-phosphate

, , , , , & show all
Pages 350-356 | Received 08 Dec 2009, Accepted 11 Jan 2010, Published online: 22 Feb 2010

References

  • Danhof M. (2004). Modeling biophase distribution (section 4). In: Jusko W, Danhof M. eds. Course on pharmacokinetic–pharmacodynamic modeling: Concept and application. Buffalo, NY: Buffalo School of Pharmacy and Pharmaceutical Sciences, The State University of New York. p. 4.
  • Dorner T, Isenberg D, Jayne D, Wiendl H, Zillikens D, Burmester G, International Roundtable on B cells as Therapeutic Target for Intervention. (2009). Current status on B-cell depletion therapy in autoimmune diseases other than rheumatoid arthritis. Autoimmun Rev. 9, 82–9.
  • Gabrielsson J, Weiner D. (2006). Transduction modeling. In: Gabrielsson J, Weiner D. eds. Pharmacokinetic and pharmacodynamic data analysis: Concepts and application, 4th ed. Stockholm: Swedish Pharmaceutical Press. p. 1165–72.
  • Mager DE, Jusko W. (2001). Pharmacodynamic modeling of time-dependent transduction systems. Clin Pharmacol Ther. 70:210–16.
  • Perlstein I, Stepensky D, Krzyzanski W, Hoffman A. (2002). A signal transduction pharmacodynamic model of the kinetics of the parasympathominetic activity of low dose scopolamine and atropine in rats. J Pharm Sci. 91:2500–10.
  • Philips JA, Paine AJ. (1990). Effect of pyridoxine on the disposition and lymphopenic effects of 2-acetyl-4(5)-tetrahydroxybutyl imidazole in the rat. Xenobiotica 20:555–62.
  • Rosen H, Goetzl E. (2005). Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network. Nat Rev Immunol. 5:560–70.
  • Schwab SR, Pereira JP, Matloubian M, Xu Y, Huang Y, Cyster JG. (2005). Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science 309:1735–9.
  • Simeoni M, Magni P, Cammia C, De Nicolao G, Croci V, Pesenti E, Germani M, Poggesi I, Rocchetti M. (2004). Predictive pharmacokinetic–pharmacodynamic modeling of tumor growth kinetics, in xenograft models after administration of anticancer agents. Cancer Res 64:1094–101.
  • Sinkeldam EJ, de Groot AP, van den Berg H, Chappel CI. (1988). The effect of pyridoxine on the number of lymphocytes in the blood of rats fed caramel colour (III). Food Chem Toxicol. 26:195–203.
  • Sun YN, DuBois D, Almon RR, Pyszczynski N, Jusko W. (1998). Dose-dependent and repeated studies for receptor/gene-mediated pharmacodynamics of methylprednisolone on glucocorticoid receptor down-regulation and tyrosine aminotransferase induction in rat liver. J Pharmacokinet Biopharm. 26:619–48.
  • Sun YN, Jusko W. (1998). Transit compartments versus gamma distribution function to model signal transduction processes in pharmacodynamics. J Pharm Sci. 87:732–7.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.