Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 40, 2010 - Issue 10
107
Views
11
CrossRef citations to date
0
Altmetric
General Xenobiochemistry

Constitutive expression of drug metabolizing enzymes and related transcription factors in cattle testis and their modulation by illicit steroids

, , , , , & show all
Pages 670-680 | Received 29 Apr 2010, Accepted 02 Jul 2010, Published online: 28 Jul 2010

References

  • Ahn T, Yun CH, Oh DB. (2006). Tissue-specific effect of ascorbic acid supplementation on the expression of cytochrome P450 2E1 and oxidative stress in streptozotocin-induced diabetic rats. Toxicol Lett 166:27–36.
  • Badawi AF, Cavalieri EL, Rogan EG. (2000). Effect of chlorinated hydrocarbons on expression of cytochrome P450 1A1, 1A2 and 1B1 and 2- and 4-hydroxylation of 17beta-estradiol in female Sprague-Dawley rats. Carcinogenesis 21:1593–1599.
  • Badawi AF, Cavalieri EL, Rogan EG. (2001). Role of human cytochrome P450 1A1, 1A2, 1B1, and 3A4 in the 2-, 4-, and 16 alpha-hydroxylation of 17beta-estradiol. Metabolism 50:1001–1003.
  • Becker J, Delayre-Orthez C, Frossard N, Pons F. (2008). Regulation of peroxisome proliferator-activated receptor-α expression during lung inflammation. Pulm Pharmacol Therapeut 21:324–330.
  • Bhattacharya N, Dufour JM, Vo MN, Okita J, Okita R, Kim KH. (2005). Differential effects of phthalates on the testis and the liver. Biol Reprod 72:745–754.
  • Bièche I, Narjoz C, Asselah T, Vacher S, Marcellin P, Lidereau R, Beaune P, de Waziers I. (2007). Reverse transcriptase-PCR quantification of mRNA levels from cytochrome (CYP)1, CYP2 and CYP3 families in 22 different human tissues. Pharmacogenet Genomics 17:731–742.
  • Buckley DB, Klaassen CD. (2007). Tissue- and gender-specific mRNA expression of UDP-glucuronosyltransferases (UGTs) in mice. Drug Metab Dispos 35:121–127.
  • Cannizzo FT, Miniscalco B, Riondato F, Bollo E, Barbarino G, Giorgi P, Mazzini C, Biolatti B. (2008). Effects of anabolic and therapeutic doses of dexamethasone on thymus morphology and apoptosis in veal calves. Vet Rec 163:448–452.
  • Cantiello M, Carletti M, Dacasto M, Martin PG, Pineau T, Capolongo F, Gardini G, Nebbia C. (2008). Cytochrome P450 inhibition profile in liver of veal calves administered a combination of 17beta-estradiol, clenbuterol, and dexamethasone for growth-promoting purposes. Food Chem Toxicol 46:2849–2855.
  • Cantiello M, Giantin M, Carletti M, Lopparelli RM, Capolongo F, Lasserre F, Bollo E, Nebbia C, Martin PG, Pineau T, Dacasto M. (2009). Effects of dexamethasone, administered for growth promoting purposes, upon the hepatic cytochrome P450 3A expression in the veal calf. Biochem Pharmacol 77:451–463.
  • Caron E, Rioux N, Nicolas O, Lebel-Talbot H, Hamelin BA. (2005). Quantification of the expression and inducibility of 12 rat cytochrome P450 isoforms by quantitative RT-PCR. J Biochem Mol Toxicol 19:368–378.
  • Carraro L, Ferraresso S, Cardazzo B, Romualdi C, Montesissa C, Gottardo F, Patarnello T, Castagnaro M, Bargelloni L. (2009). Expression profiling of skeletal muscle in young bulls treated with steroidal growth promoters. Physiol Genomics 38:138–148.
  • Cavaco JE, Laurentino SS, Barros A, Sousa M, Socorro S. (2009). Estrogen receptors alpha and beta in human testis: both isoforms are expressed. Syst Biol Reprod Med 55:137–144.
  • Cederroth CR, Schaad O, Descombes P, Chambon P, Vassalli JD, Nef S. (2007). Estrogen receptor alpha is a major contributor to estrogen-mediated fetal testis dysgenesis and cryptorchidism. Endocrinology 148:5507–5519.
  • Choudhary D, Jansson I, Schenkman JB, Sarfarazi M, Stoilov I. (2003). Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues. Arch Biochem Biophys 414:91–100.
  • Choudhary D, Jansson I, Stoilov I, Sarfarazi M, Schenkman JB. (2005). Expression patterns of mouse and human CYP orthologs (families 1-4) during development and in different adult tissues. Arch Biochem Biophys 436:50–61.
  • Courtheyn D, Le Bizec B, Brambilla G, De Brabander HF, Cobbaert E, Van de Wiele M, Vercammen J, De Wasch K. (2002). Recent developments in the use and abuse of growth promoters. Anal Chim Acta 473:71–82.
  • Cuzzocrea S, Bruscoli S, Crisafulli C, Mazzon E, Agostini M, Muià C, Esposito E, Di Virgilio R, Meli R, Vegeto E, Maggi A, Riccardi C. (2007). Estrogen receptor antagonist fulvestrant (ICI 182,780) inhibits the anti-inflammatory effect of glucocorticoids. Mol Pharmacol 71:132–144.
  • Cuzzocrea S, Bruscoli S, Mazzon E, Crisafulli C, Donato V, Di Paola R, Velardi E, Esposito E, Nocentini G, Riccardi C. (2008). Peroxisome proliferator-activated receptor-α contributes to the anti-inflammatory activity of glucocorticoids. Mol Pharmacol 73:323–337.
  • Deb S, Kawai M, Chang TK, Bandiera SM. (2010). CYP1B1 expression in rat testis and Leydig cells is not inducible by aryl hydrocarbon receptor agonists. Xenobiotica 40:447–457.
  • De Maria R, Divari S, Goria M, Bollo E, Cannizzo FT, Olivero M, Barbarino G, Biolatti B. (2009). 17beta-oestradiol-induced gene expression in cattle prostate: biomarkers to detect illegal use of growth promoters. Vet Rec 164:459–464.
  • Genovese T, Esposito E, Mazzon E, Crisafulli C, Paterniti I, Di Paola R, Galuppo M, Bramanti P, Cuzzocrea S. (2009). PPAR-alpha modulates the anti-inflammatory effect of glucocorticoids in the secondary damage in experimental spinal cord trauma. Pharmacol Res 59:338–350.
  • Giantin M, Carletti M, Capolongo F, Pegolo S, Lopparelli RM, Gusson F, Nebbia C, Cantiello M, Martin P, Pineau T, Dacasto M. (2008). Effect of breed upon cytochromes P450 and phase II enzymes expression in cattle liver. Drug Metab Dispos 36:885–893.
  • Giantin M, Lopparelli RM, Zancanella V, Martin PG, Polizzi A, Gallina G, Gottardo F, Montesissa C, Ravarotto L, Pineau T, Dacasto M. (2010). Effects of illicit dexamethasone upon hepatic drug metabolizing enzymes and related transcription factors mRNAs and their potential use as biomarkers in cattle. J Agric Food Chem 58:1342–1349.
  • Greger DL, Blum JW. (2007). Effects of dexamethasone on mRNA abundance of nuclear receptors and hepatic nuclear receptor target genes in neonatal calves. J Anim Physiol Anim Nutr (Berl) 91:62–67.
  • Gueugnon F, Gondcaille C, Leclercq S, Bellenger J, Bellenger S, Narce M, Pineau T, Bonnetain F, Savary S. (2007). Dehydroepiandrosterone up-regulates the Adrenoleukodystrophy-related gene (ABCD2) independently of PPARalpha in rodents. Biochimie 89:1312–1321.
  • Healy LN, Pluta LJ, Recio L. (1999). Expression and distribution of cytochrome P450 2E1 in B6C3F1 mouse liver and testes. Chem Biol Interact 121:199–207.
  • Honkakoski P, Negishi M. (2000). Regulation of cytochrome P450 (CYP) genes by nuclear receptors. Biochem J 347:321–337.
  • Hu GX, Lian QQ, Lin H, Latif SA, Morris DJ, Hardy MP, Ge RS. (2008). Rapid mechanisms of glucocorticoid signaling in the Leydig cell. Steroids 73:1018–1024.
  • Jalouli M, Carlsson L, Améen C, Lindén D, Ljungberg A, Michalik L, Edén S, Wahli W, Oscarsson J. (2003). Sex difference in hepatic peroxisome proliferator-activated receptor alpha expression: influence of pituitary and gonadal hormones. Endocrinology 144:101–109.
  • Järveläinen HA, Lukkari TA, Heinaro S, Sippel H, Lindros KO. (2001). The antiestrogen toremifene protects against alcoholic liver injury in female rats. J Hepatol 35:46–52.
  • Jiang Y, Kuo CL, Pernecky SJ, Piper WN. (1998). The detection of cytochrome P450 2E1 and its catalytic activity in rat testis. Biochem Biophys Res Commun 246:578–583.
  • Kawase A, Fujii A, Negoro M, Akai R, Ishikubo M, Komura H, Iwaki M. (2008). Differences in cytochrome P450 and nuclear receptor mRNA levels in liver and small intestines between SD and DA rats. Drug Metab Pharmacokinet 23:196–206.
  • Klose TS, Blaisdell JA, Goldstein JA. (1999). Gene structure of CYP2C8 and extrahepatic distribution of the human CYP2Cs. J Biochem Mol Toxicol 13:289–295.
  • Lee CM, Kim BY, Li L, Morgan ET. (2008). Nitric oxide-dependent proteasomal degradation of cytochrome P450 2B proteins. J Biol Chem 283:889–898.
  • Leung GS, Kawai M, Tai JK, Chen J, Bandiera SM, Chang TK. (2009). Developmental expression and endocrine regulation of CYP1B1 in rat testis. Drug Metab Dispos 37:523–528.
  • Livak KJ, Schmittgen TD. (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25:402–408.
  • Luo G, Guenthner T, Gan LS, Humphreys WG. (2004). CYP3A4 induction by xenobiotics: biochemistry, experimental methods and impact on drug discovery and development. Curr Drug Metab 5:483–505.
  • Machala M, Neca J, Drábek P, Ulrich R, Sabatová V, Nezveda K, Raszyk J, Gajdusková V. (1998). Effects of chronic exposure to PCBs on cytochrome P450 systems and steroidogenesis in liver and testis of bulls (Bos taurus). Comp Biochem Physiol, Part A Mol Integr Physiol 120:65–70.
  • Maciel SM, Chamberlain CS, Wettemann RP, Spicer LJ. (2001). Dexamethasone influences endocrine and ovarian function in dairy cattle. J Dairy Sci 84:1998–2009.
  • Martin LJ, Tremblay JJ. (2008). Glucocorticoids antagonize cAMP-induced Star transcription in Leydig cells through the orphan nuclear receptor NR4A1. J Mol Endocrinol 41:165–175.
  • Mattes WB, Daniels KK, Summan M, Xu ZA, Mendrick DL. (2006). Tissue and species distribution of the glutathione pathway transcriptome. Xenobiotica 36:1081–1121.
  • Monostory K, Pascussi JM, Kóbori L, Dvorak Z. (2009). Hormonal regulation of CYP1A expression. Drug Metab Rev 41:547–572.
  • Nakamura A, Nakajima M, Yamanaka H, Fujiwara R, Yokoi T. (2008). Expression of UGT1A and UGT2B mRNA in human normal tissues and various cell lines. Drug Metab Dispos 36:1461–1464.
  • Nakata K, Tanaka Y, Nakano T, Adachi T, Tanaka H, Kaminuma T, Ishikawa T. (2006). Nuclear receptor-mediated transcriptional regulation in Phase I, II, and III xenobiotic metabolizing systems. Drug Metab Pharmacokinet 21:437–457.
  • Nishimura M, Koeda A, Suganuma Y, Suzuki E, Shimizu T, Nakayama M, Satoh T, Narimatsu S, Naito S. (2007). Comparison of inducibility of CYP1A and CYP3A mRNAs by prototypical inducers in primary cultures of human, cynomolgus monkey, and rat hepatocytes. Drug Metab Pharmacokinet 22:178–186.
  • Nishimura M, Naito S. (2006). Tissue-specific mRNA expression profiles of human phase I metabolizing enzymes except for cytochrome P450 and phase II metabolizing enzymes. Drug Metab Pharmacokinet 21:357–374.
  • Nishimura M, Naito S, Yokoi T. (2004). Tissue-specific mRNA expression profiles of human nuclear receptor subfamilies. Drug Metab Pharmacokinet 19:135–149.
  • Nishimura M, Yaguti H, Yoshitsugu H, Naito S, Satoh T. (2003). Tissue distribution of human cytochrome P450 isoforms assessed by high-sensitivity real-time reverse-transcription PCR. Yakuga Zasshi 123:369–375.
  • Novak RF, Woodcroft KJ. (2000). The alcohol-inducible form of cytochrome P450 (CYP2E1): role in toxicology and regulation of expression. Arch Pharm Res 23:267–282.
  • Paquette A, Wang D, Jankowski M, Gutkowska J, Lavoie JM. (2008). Effects of ovariectomy on PPAR alpha, SREBP-1c, and SCD-1 gene expression in the rat liver. Menopause 15:1169–1175.
  • Parthasarathy C, Yuvaraj S, Ilangovan R, Janani P, Kanagaraj P, Balaganesh M, Natarajan B, Sittadjody S, Balasubramanian K. (2009). Differential response of Leydig cells in expressing 11beta-HSD type I and cytochrome P450 aromatase in male rats subjected to corticosterone deficiency. Mol Cell Endocrinol 311:18–23.
  • Pascussi JM, Drocourt L, Gerbal-Chaloin S, Fabre JM, Maurel P, Vilarem MJ. (2001). Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane X receptor. Eur J Biochem 268:6346–6358.
  • Payne AH. (1990). Hormonal regulation of cytochrome P450 enzymes, cholesterol side-chain cleavage and 17 alpha-hydroxylase/C17-20 lyase in Leydig cells. Biol Reprod 42:399–404.
  • Pelkonen O, Turpeinen M, Hakkola J, Honkakoski P, Hukkanen J, Raunio H. (2008). Inhibition and induction of human cytochrome P450 enzymes: current status. Arch Toxicol 82:667–715.
  • Rabahi F, Brûlé S, Sirois J, Beckers JF, Silversides DW, Lussier JG. (1999). High expression of bovine alpha glutathione S-transferase (GSTA1, GSTA2) subunits is mainly associated with steroidogenically active cells and regulated by gonadotropins in bovine ovarian follicles. Endocrinology 140:3507–3517.
  • Reiter M, Walf VM, Christians A, Pfaffl MW, Meyer HH. (2007). Modification of mRNA expression after treatment with anabolic agents and the usefulness for gene expression-biomarkers. Anal Chim Acta 586:73–81.
  • Rekawiecki R, Nowik M, Kotwica J. (2005). Stimulatory effect of LH, PGE2 and progesterone on StAR protein, cytochrome P450 cholesterol side chain cleavage and 3beta hydroxysteroid dehydrogenase gene expression in bovine luteal cells. Prostaglandins Other Lipid Mediat 78:169–184.
  • Rengarajan S, Balasubramanian K. (2008). Corticosterone induces steroidogenic lesion in cultured adult rat Leydig cells by reducing the expression of star protein and steroidogenic enzymes. J Cell Biochem 103:1472–1487.
  • Riedmaier I, Tichopad A, Reiter M, Pfaffl MW, Meyer HH. (2009). Identification of potential gene expression biomarkers for the surveillance of anabolic agents in bovine blood cells. Anal Chim Acta 638:106–113.
  • Riccardi L, Mazzon E, Bruscoli S, Esposito E, Crisafulli C, Di Paola R, Caminiti R, Riccardi C, Cuzzocrea S. (2009). Peroxisome proliferator-activated receptor-alpha modulates the anti-inflammatory effect of glucocorticoids in a model of inflammatory bowel disease in mice. Shock 31:308–316.
  • Sampol E, Mirrione A, Villard PH, Piccerelle P, Scoma H, Berbis P, Barra Y, Durand A, Lacarelle B. (1997). Evidence for a tissue-specific induction of cutaneous CYP2E1 by dexamethasone. Biochem Biophys Res Commun 235:557–561.
  • Schuppe HC, Wieneke P, Donat S, Fritsche E, Köhn FM, Abel J. (2000). Xenobiotic metabolism, genetic polymorphisms and male infertility. Andrologia 32:255–262.
  • Seliskar M, Rozman D. (2007). Mammalian cytochromes P450–importance of tissue specificity. Biochim Biophys Acta 1770:458–466.
  • Son DS, Roby KF, Rozman KK, Terranova PF. (2002). Estradiol enhances and estriol inhibits the expression of CYP1A1 induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in a mouse ovarian cancer cell line. Toxicology 176:229–243.
  • Sonneveld E, Jonas A, Meijer OC, Brouwer A, van der Burg B. (2007). Glucocorticoid-enhanced expression of dioxin target genes through regulation of the rat aryl hydrocarbon receptor. Toxicol Sci 99:455–469.
  • Stolker AA, Brinkman UA. (2005). Analytical strategies for residue analysis of veterinary drugs and growth-promoting agents in food-producing animals–a review. J Chromatogr A 1067:15–53.
  • Strauss L, Kallio J, Desai N, Pakarinen P, Miettinen T, Gylling H, Albrecht M, Mäkelä S, Mayerhofer A, Poutanen M. (2009). Increased exposure to estrogens disturbs maturation, steroidogenesis, and cholesterol homeostasis via estrogen receptor alpha in adult mouse Leydig cells. Endocrinology 150:2865–2872.
  • Toffolatti L, Rosa Gastaldo L, Patarnello T, Romualdi C, Merlanti R, Montesissa C, Poppi L, Castagnaro M, Bargelloni L. (2006). Expression analysis of androgen-responsive genes in the prostate of veal calves treated with anabolic hormones. Domest Anim Endocrinol 30:38–55.
  • Van Merris V, Van Wemmel K, Cortvrindt R. (2007). In vitro effects of dexamethasone on mouse ovarian function and pre-implantation embryo development. Reprod Toxicol 23:32–41.
  • Venkatakrishnan K, Von Moltke LL, Greenblatt DJ. (2001). Human drug metabolism and the cytochromes P450: application and relevance of in vitro models. J Clin Pharmacol 41:1149–1179.
  • Vrzal R, Stejskalova L, Monostory K, Maurel P, Bachleda P, Pavek P, Dvorak Z. (2009). Dexamethasone controls aryl hydrocarbon receptor (AhR)-mediated CYP1A1 and CYP1A2 expression and activity in primary cultures of human hepatocytes. Chem Biol Interact 179:288–296.
  • Weber MA, Groos S, Höpfl U, Spielmann M, Aumüller G, Konrad L. (2000). Glucocorticoid receptor distribution in rat testis during postnatal development and effects of dexamethasone on immature peritubular cells in vitro. Andrologia 32:23–30.
  • Yamazaki T, Shimodaira M, Kuwahara H, Wakatsuki H, Horiuchi H, Matsuda H, Kominami S. (2005). Tributyltin disturbs bovine adrenal steroidogenesis by two modes of action. Steroids 70:913–921.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.