Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 43, 2013 - Issue 7
213
Views
7
CrossRef citations to date
0
Altmetric
Animal Pharmacokinetics and Metabolism

Metabolite profile analysis of aconitine in rabbit stomach after oral administration by liquid chromatography/electrospray ionization/multiple-stage tandem mass spectrometry

, , , &
Pages 628-635 | Received 19 Sep 2012, Accepted 23 Nov 2012, Published online: 26 Dec 2012

References

  • Borcsa B, Widowitz U, Csupor D, et al. (2011). Semisynthesis and pharmacological investigation of lipo-alkaloids prepared from aconitine. Fitoterapia 82:365–8
  • Chan TYK. (2011). Causes and prevention of herb-induced aconite poisonings in Asia. Hum Exp Toxicol 30:2023–6
  • Consolini M, Sega M, Zanetti C, et al. (2012). Emulsification of simulated gastric fluids protects wheat alpha-amylase inhibitor 0.19 epitopes from digestion. Food Anal Methods 5:234–43
  • Delgado S, Suárez A, Mayo B. (2011). Identification, typing and characterisation of Propionibacterium strains from healthy mucosa of the human stomach. Int J Food Microbiol 149:65–72
  • Gupta B, Rani M, Salunke R, Kumar R. (2012). In vitro and in vivo studies on degradation of quinalphos in rats. J Hazard Mater 213:285–91
  • He F, Dou DQ, Sun Y, et al. (2012). Plasma pharmacokinetics and tissue distribution of arctiin and its main metabolite in rats by HPLC-UV and LC-MS. Planta Med 78:800–6
  • Kentaro W, Makoto N, Hideyuki H, et al. (2005). Effects of long-term administrations of aconitine on electrocardiogram and tissue concentrations of aconitine and its metabolites in mice. Forensic Sci Int 148:21–9
  • Li N, Cao R, Sui ZG, et al. (2012). Intestinal transport of pure diester-type alkaloids from an aconite extract across the Caco-2 cell monolayer model. Planta Med 78:692–7
  • Liu WY, Xu WL, Li P, et al. (2009). Tissue distribution and excretion of baicalein and its main metabolite in rats by LC-MS/MS. J China Pharm Univ 40:348–52
  • Pullela R, Young L, Gallagher B, et al. (2008). A case of fatal aconitine poisoning by monkshood ingestion. J Forensic Sci 53:491–4
  • Sarti F, Barthelmes J, Iqbal J, et al. (2011). Intestinal enzymatic metabolism of drugs. J Pharm Pharmacol 63:392–9
  • Singhuber J, Zhu M, Prinz S, Kopp B. (2009). Aconitum in traditional Chinese medicine – a valuable drug or an unpredictable risk? J Ethnopharmacol 126:18–30
  • Strzelecki A, Pichon N, Gaulier JM, et al. (2010). Acute toxic herbal intake in a suicide attempt and fatal refractory ventricular arrhythmia. Basic Clin Pharmacol 107:698–9
  • Sui ZG, Jiang YQ, Liu ZQ, et al. (2009). Study on metabolites of aconitine in rabbit intestines by using LC/ESI-MSn. Acta Chim Sinica 67:2439–44
  • Suzuki Y, Oyama T, Ishige A, et al. (1994). Antinociceptive mechanism of the aconitine alkaloids mesaconitine and benzoylmesaconine. Planta Med 60:391–4
  • Tang L, Ye L, Chang L, et al. (2011). Involvement of CYP3A4/5 and CYP2D6 in the metabolism of aconitine using human liver microsomes and recombinant CYP450 enzymes. Toxicol Lett 202:47–54
  • Turabekova MA, Rasulev BF, Dzhakhangirov FN, Salikhov SI. (2008). Aconitum and delphinium alkaloids: “drug-likeness” descriptors related to toxic mode of action. Environ Toxicol Pharmacol 25:310–20
  • Wang Y, Liu ZQ, Song FR, Liu SY. (2002). Electrospray ionization tandem mass spectrometry study of the aconitines in the root of aconite. Rapid Commun Mass Spectrom 16:2075–82
  • Wang Y, Shi L, Song FR, et al. (2003). Exploring the ester-exchange reactions of diesterditerpenoid alkaloids in the aconite decoction process by electrospray ionization tandem mass spectrometry. Rapid Commun Mass Spectrom 17:279–84
  • Wang YG, Wang SQ, Liu YX, et al. (2006). Characterization of metabolites and cytochrome P450 isoforms involved in the microsomal metabolism of aconitine. J Chromatogr B 844:292–300
  • Wang ZH, Wen J, He Y. (2004). Research on pharmacokinetic of aconitine by LC-MS. J Instrumental Anal 23:51–6
  • Yue H, Pi ZF, Song FR, et al. (2009). Studies on the aconitine-type alkaloids in the roots of Aconitum Carmichaeli Debx. by HPLC/ESI/MS/MSn. Talanta 77:1800–7
  • Zhang WT, Li Q, Zhu M, et al. (2008). Direct determination of polydatin and its metabolite in rat excrement. Chem Pharm Bull 56:1592–5
  • Zhang HG, Sun Y, Duan MY, et al. (2005). Separation and identification of Aconitum alkaloids and their metabolites in human urine. Toxicon 46:500–6
  • Zhao YF, Song FR, Guo XH, Liu SY. (2008). Studies on the biotransformation of aconitine in human intestinal bacteria using soft ionization mass spectrometry. Chem J Chin Univ 29:55–9
  • Zhao YF, Song FR, Yue H, et al. (2007). Biotransformation of deoxyaconitine of metabolite of aconitine by human intestinal bacteria and electrospray ionization tandem mass spectrometry. Chem J Chin Univ 28:2051–5
  • Zhou YP, Liu WH, Zeng GY, et al. (1984). The toxicity of aconitine and its analogs and their effects on cardiac contractile function. Yao Xue Xue Bao 19:641–6

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.