IFN-γ regulates cytochrome 3A29 through pregnane X receptor in pigs

References

• Antolino-Lobo I, Meulenbelt J, Nijmeijer SM, et al. (2011). 3,4-Methylenedioxymethamphetamine (MDMA) interacts with therapeutic drugs on CYP3A by inhibition of pregnane X receptor (PXR) activation and catalytic enzyme inhibition. Toxicol Lett 203:82–91
   PubMed Web of Science ®Google Scholar
• Anzenbacherova E, Baranova J, Zuber R, et al. (2005). Model systems based on experimental animals for studies on drug metabolism in man: (Mini) pig cytochromes P450 3A29 and 2E1. Basic Clin Pharmacol Toxicol 96:244–5
   PubMed Web of Science ®Google Scholar
• Babiuk LA, Sordillo LM, Campos M, et al. (1991). Application of interferons in the control of infectious diseases of cattle. J Dairy Sci 74:4385–98
   PubMed Web of Science ®Google Scholar
• Balk MW. (1987). Emerging models in the USA: swine, woodchucks, and the hairless guinea pig. Prog Clin Biol Res 229:311–26
   PubMedGoogle Scholar
• Balkwill FR, Burke F. (1989). The cytokine network. Immunol Today 10:299–304
   PubMedGoogle Scholar
• Baron S, Tyring SK, Fleischmann WR, et al. (1991). The interferons. Mechanisms of action and clinical applications. JAMA 266:1375–83
   PubMed Web of Science ®Google Scholar
• Basham TY, Merigan TC. (1983). Recombinant interferon-g increases HLA-DR synthesis and expression. J Immunol 130:1492–4
   PubMed Web of Science ®Google Scholar
• Beigneux AP, Moser AH, Shigenaga JK, et al. (2002). Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase response. Biochem Biophys Res Commun 293:145--9
   Google Scholar
• Bertilsson G, Heidrich J, Svensson K, et al. (1998). Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. Proc Natl Acad Sci USA 95:12208–13
   PubMed Web of Science ®Google Scholar
• Campbell IL, Krucker T, Steffensen S, et al. (1999). Structural and functional neuropathology in transgenic mice with CNS expression of IFN-alpha. Brain Res 835:46–61
   PubMed Web of Science ®Google Scholar
• Clement JQ, Wilkinson MF. (2000). Rapid induction of nuclear transcripts and inhibition of intron decay in response to the polymerase II inhibitor DRB. J Mol Biol 299:1179–91
   PubMedGoogle Scholar
• Georgiades JA. (1993). A new approach to chronic viral disease therapy by cytokines. Arch Immunol Ther Exp 41:173–8
   Google Scholar
• Grandvaux N, ten Over BR, Servant MJ, Hiscott J. (2002). The interferon antiviral response: from viral invasion to evasion. Curr Opin Infect Dis 15:259–67
   PubMed Web of Science ®Google Scholar
• Gu X, Ke S, Liu D, et al. (2006). Role of NF-kappaB in regulation of PXR-mediated gene expression: a mechanism for the suppression of cytochrome P-450 3A4 by proinflammatory agents. J Biol Chem 281:17882–9
   PubMed Web of Science ®Google Scholar
• Harmsen S, Meijerman I, Beijnen JH, Schellens JH. (2009). Nuclear receptor mediated induction of cytochrome P450 3A4 by anticancer drugs: a key role for the pregnane X receptor. Cancer Chemother Pharmacol 64:35–43
   PubMed Web of Science ®Google Scholar
• Kliewer SA, Goodwin B, Willson TM. (2002). The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism. Endocr Rev 23:687–702
   PubMed Web of Science ®Google Scholar
• Kolodkin A, Sahin N, Phillips A, et al. (2013). Optimization of stress response through the nuclear receptor-mediated cortisol signalling network. Nat Commun 4:1792
   Google Scholar
• Lehmann JM, McKee DD, Watson MA, et al. (1998). The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J Clin Invest 102:1016--23
   Google Scholar
• Li LJ, Du WB, Zhang YM, et al. (2006). Evaluation of a bioartificial liver based on a nonwoven fabric bioreactor with porcine hepatocytes in pigs. J Hepatol 44:317–24
   Google Scholar
• Maruyama M, Totsugawa T, Kunieda T, et al. (2003). Hepatocyte isolation and transplantation in the pig. Cell Transplant 12:593–8
   Google Scholar
• Meijerman I, Beijnen JH, Schellens JH. (2006). Herb-drug interactions in oncology: focus on mechanisms of induction. Oncologist 11:742–52
   PubMed Web of Science ®Google Scholar
• Mosmann T. (1983). Rapid Colorimetric Assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65:55--63
   Google Scholar
• Moore BR. (1996). Clinical application of interferons in large animal medicine. J Am Vet Med Assoc 208:1711–15
   Google Scholar
• Nannelli A, Chirulli V, Longo V, Gervasi PG. (2008). Expression and induction by rifampicin of CAR- and PXR-regulated CYP2B and CYP3A in liver, kidney and airways of pig. Toxicology 252:105–12
   PubMed Web of Science ®Google Scholar
• Pace JL, Russell SW, LeBlanc PA, Murasco DM. (1985). Comparative effects of various classes of mouse interferons on macrophage activation for tumor cell killing. J Immunol 134:977–81
   PubMed Web of Science ®Google Scholar
• Radaeva S, Jaruga B, Hong F, et al. (2002). Interferon-alpha activates multiple STAT signals and down-regulates c-Met in primary human hepatocytes. Gastroenterology 122:1020–34
   PubMed Web of Science ®Google Scholar
• Rendic S, DiCarlo FJ. (1997). Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors. Drug Metab Rev 29:413–580
   PubMed Web of Science ®Google Scholar
• Rodriguez-Antona C, Gomez A, Karlgren M, et al. (2010). Molecular genetics and epigenetics of the cytochrome P450 gene family and its relevance for cancer risk and treatment. Hum Genet 127:1–17
   PubMed Web of Science ®Google Scholar
• Ronis MJ, Chen Y, Liu X, et al. (2011). Enhanced expression and glucocorticoid-inducibility of hepatic cytochrome P450 3A involve recruitment of the pregnane-X-receptor to promoter elements in rats fed soy protein isolate. J Nutr 141:10–16
   PubMed Web of Science ®Google Scholar
• Savan R, Ravichandran S, Collins JR, et al. (2009). Structural conservation of interferon gamma among vertebrates. Cytokine Growth Factor Rev 20:115–24
   PubMed Web of Science ®Google Scholar
• Shang H, Yang J, Liu Y, Wei H. (2009). Tissue distribution of CYP3A29 mRNA expression in Bama miniature pig by quantitative reverse transcriptase-polymerase chain reaction (RT-PCR). Xenobiotica 39:423–9
   PubMed Web of Science ®Google Scholar
• Shi D, Yang D, Yan B. (2010). Dexamethasone transcriptionally increases the expression of the pregnane X receptor and synergistically enhances pyrethroid esfenvalerate in the induction of cytochrome P450 3A23. Biochem Pharmacol 80:1274–83
   PubMed Web of Science ®Google Scholar
• Shimada T, Yamazaki H, Mimura M, et al. (1994). Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J Pharmacol Exp Ther 270:414–23
   PubMed Web of Science ®Google Scholar
• Soucek P, Zuber R, Anzenbacherová E, et al. (2001). Minipig cytochrome P450 3A, 2A and 2C enzymes have similar properties to human analogs. BMC Pharmacol 1:11
   PubMedGoogle Scholar
• Staeheli P. (1990). Interferon-induced protein and antiviral state. Adv Virus Res 38:147–200
   PubMedGoogle Scholar
• Steinbach F, Maeul S, Beier I. (2002). Recombinant equine interferons: expression cloning and biological activity. Vet Immunol Immunopathol 84:83–95
   PubMed Web of Science ®Google Scholar
• Thörn HA, Lundahl A, Schrickx JA, et al. (2011). Drug metabolism of CYP3A4, CYP2C9 and CYP2D6 substrates in pigs and humans. Eur J Pharm Sci 43:89–98
   PubMed Web of Science ®Google Scholar
• Walrand F, Picard F, McCullough K, et al. (1989). Recombinant bovine interferon-gamma enhances expression of class I and class II bovine lymphocyte antigens. Vet Immunol Immunopathol 22:379–83
   Google Scholar
• Yang J, Hao C, Yang D, et al. (2010). Pregnane X receptor is required for interleukin-6-mediated down-regulation of cytochrome P450 3A4 in human hepatocytes. Toxicol Lett 197:219–26
   PubMed Web of Science ®Google Scholar
• Yao M, Dai M, Liu Z, et al. (2011). Comparison of the substrate kinetics of pig CYP3A29 with pig liver microsomes and human CYP3A4. Biosci Rep 31:211–20
   PubMed Web of Science ®Google Scholar
• Yoshiji H, Noguchi R, Kuriyama S, et al. (2005). Combination of interferon and angiotensin-converting enzyme inhibitor, perindopril, suppresses liver carcinogenesis and angiogenesis in mice. Oncol Rep 13:491–5
   PubMed Web of Science ®Google Scholar
• Zamaratskaia G, Zlabek V, Ropstad E, Andresen Ø. (2012). In vitro and in vivo association of porcine hepatic cytochrome P450 3A and 2C activities with testicular steroids. Reprod Domest Anim 47:891–8
   Google Scholar