Metronidazole reduces the expression of cytochrome P450 enzymes in HepaRG cells and cryopreserved human hepatocytes

References

• Aninat C, Piton A, Glaise D, et al. (2006). Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells. Drug Metab Dispos 34:75–83
   PubMed Web of Science ®Google Scholar
• Anthérieu S, Chesné C, Li R, et al. (2010). Stable expression, activity, and inducibility of cytochromes P450 in differentiated HepaRG cells. Drug Metab Dispos 38:516–25
   PubMed Web of Science ®Google Scholar
• Brusis T, Luckhaupt H. (1989). Fetor from ulcerated head and neck tumors: causation and therapy. Ann Otol Rhinol Laryngol 98:615–17
   Google Scholar
• Cooke CE, Sklar GE, Nappi JM. (1996). Possible pharmacokinetic interaction with quinidine: ciprofloxacin or metronidazole? Ann Pharmacother 30:364–6
   Google Scholar
• Drew RJ, Jeffery HM, Grover PM. (2010). Warfarin and UDP-glucuronosyl transferases: writing a new chapter of metabolism. Drug Metab Rev 42:53–9
   Google Scholar
• Duret C, Daujat-Chavanieu M, Pascussi JM, et al. (2006). Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor. Mol Pharmacol 70:329–39
   PubMed Web of Science ®Google Scholar
• Finlay IG, Bowszyc J, Ramlau C, Gwiezdzinski Z. (1996). The effect of topical 0.75% metronidazole gel on malodorous cutaneous ulcers. J Pain Symptom Manage 11:158–62
   Google Scholar
• Gerets HH, Tilmant K, Gerin B, et al. (2012). Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins. Cell Biol Toxicol 28:69–87
   PubMed Web of Science ®Google Scholar
• Herzig K, Johnson DW. (1999). Marked elevation of blood cyclosporin and tacrolimus levels due to concurrent metronidazole therapy (letter). Nephrol Dial Transplant 14:521–3
   Google Scholar
• Howard-Thompson A, Hurdle AC, Arnold LB, et al. (2008). Intracerebral hemorrhage secondary to a warfarin-metronidazole interaction. Am J Geriatr Pharmacother 6:33–6
   Google Scholar
• Iida J, Kudo T, Shimada K, et al. (2013). Investigation of the safety of topical metronidazole from a pharmacokinetic perspective. Biol Pharm Bull 36:89–95
   Google Scholar
• Kaminsky LS, Zhang ZY. (1997). Human P450 metabolism of warfarin. Pharmacol Ther 73:67–74
   PubMed Web of Science ®Google Scholar
• Kanebratt KP, Andersson TB. (2008). HepaRG cells as an in vitro model for evaluation of cytochrome P450 induction in humans. Drug Metab Dispos 36:137–45
   PubMed Web of Science ®Google Scholar
• Kuge S, Tokuda Y, Ohta M, et al. (1996). Use of metronidazole gel to control malodor in advanced and recurrent breast cancer. Jpn J Clin Oncol 26:207–10
   Google Scholar
• Lane MA, Zeringue A, McDonald JR. (2014). Serious bleeding events due to warfarin and antibiotic co-prescription in a cohort of veterans. Am J Med 127:657–63
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25:402–8
   PubMed Web of Science ®Google Scholar
• Maurice M, Pichard L, Daujat M, et al. (1992). Effects of imidazole derivatives on cytochromes P450 from human hepatocytes in primary culture. FASEB J 6:752–8
   PubMed Web of Science ®Google Scholar
• Moore LB, Parks DJ, Jones SA, et al. (2000). Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. J Biol Chem 275:15122–7
   PubMed Web of Science ®Google Scholar
• Nishimura M, Ueda N, Naito S. (2003). Effects of dimethyl sulfoxide on the gene induction of cytochrome P450 isoforms, UGT-dependent glucuronosyl transferase isoforms, and ABCB1 in primary culture of human hepatocytes. Biol Pharm Bull 26:1052–6
   Google Scholar
• O'Reilly RA. (1976). The stereoselective interaction of warfarin and metronidazole in man. N Engl J Med 295:354–7
   PubMed Web of Science ®Google Scholar
• Package insert of Flagyl. [Online] Available from: http://www.info.pmda.go.jp/downfiles/ph/PDF/340018_6419002F1131_1_09.pdf [last accessed 26 Nov 2014]
   Google Scholar
• Page 2nd RL, Klem PM, Rogers C. (2005). Potential elevation of tacrolimus trough concentrations with concomitant metronidazole therapy. Ann Pharmacother 39:1109–13
   Google Scholar
• Patterson BD. (1994). Possible interaction between metronidazole and carbamazepine (letter). Ann Pharmacother 28:1303–4
   Google Scholar
• Pelkonen O, Turpeinen M, Hakkola J, et al. (2008). Inhibition and induction of human cytochrome P450 enzymes: current status. Arch Toxicol 82:667–715
   PubMed Web of Science ®Google Scholar
• Rettie AE, Korzekwa KR, Kunze KL, et al. (1992). Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions. Chem Res Toxicol 5:54–9
   PubMed Web of Science ®Google Scholar
• Schwartz DE, Jeunet F. (1976). Comparative pharmacokinetic studies of ornidazole and metronidazole in man. Chemotherapy 22:19–29
   PubMed Web of Science ®Google Scholar
• Seiga K, Yamaji K, Sugiyama Y. (1974). Trichomonas vaginalis infection chemotherapy by metronidazole. World Obstet Gynecol 26:209–14
   Google Scholar
• Svecova L, Vrzal R, Burysek L, et al. (2008). Azole antimycotics differentially affect rifampicin-induced pregnane X receptor-mediated CYP3A4 gene expression. Drug Metab Dispos 36:339–48
   PubMed Web of Science ®Google Scholar
• Wang JS, Backman JT, Kivistö KT, Neuvonen PJ. (2000). Effects of metronidazole on midazolam metabolism in vitro and in vivo. Eur J Clin Pharmacol 56:555–9
   PubMed Web of Science ®Google Scholar