The metabolism of 4-bromoaniline in the bile-cannulated rat: application of ICPMS (^79/81Br), HPLC-ICPMS & HPLC-oaTOFMS

References

• Abou-Shakra F, Sage AB, Castro-Perez J, et al. (2002). High-performance liquid chromatography–UV diode array, inductively-coupled plasma mass spectrometry (ICPMS) and orthogonal acceleration time-of- flight mass spectrometry (oa-TOFMS) applied to the simultaneous detection and identification of metabolites of 4-bromoaniline in rat urine. Chromatographia 55:S9–13
   Web of Science ®Google Scholar
• Athersuch TJ, Wilson ID, Keun HC, Lindon JC. (2013). Development of quantitative structure-metabolism (QSMR) relationships for substituted anilines based on computational chemistry. Xenobiotica 43:1–11
   PubMedGoogle Scholar
• Corcoran O, Nicholson JK, Lenz EM, et al. (2000). Directly coupled liquid chromatography with inductively coupled plasma mass spectrometry and orthogonal acceleration time-of-flight mass spectrometry for the identification of drug metabolites in urine: application to diclofenac using chlorine and sulphur detection. Rapid Comm Mass Spectrom 14:2377–84
   PubMed Web of Science ®Google Scholar
• Cuyckens F, Balcaen LI, De Wolf K, et al. (2008). Use of the bromine isotope ratio in HPLC-ICP-MS and HPLC-ESI-MS analysis of a new drug in development. Anal Bioanal Chem 390:1717–29
   PubMed Web of Science ®Google Scholar
• Duckett CJ, Lindon JC, Walker H, et al. (2006). Metabolism of 3-chloro-4-fluoroaniline in rat using [14C]-radiolabelling, 19F NMR spectroscopy, HPLC-MS/MS. HPLC-ICPMS and HPLC-NMR. Xenobiotica 36:59–77
   PubMed Web of Science ®Google Scholar
• Duckett CJ, Wilson ID, Douce DS, et al. (2007) Metabolism of 2-fluoro-4-iodoaniline in the earthworm Eisenia veneta using 19F NMR spectroscopy, HPLC-MS, and HPLC-ICPMS (127I). Xenobiotica 37:1378–93
   PubMed Web of Science ®Google Scholar
• Duckett CJ, Wilson ID, Walker H, et al. (2003). High-performance liquid chromatography/inductively coupled plasma mass spectrometry with iodine-specific detection for profiling the metabolites produced in the earthworm Eisenia veneta by exposure to 2-fluoro-4-iodoaniline. Rapid Comm Mass Spectrom 17:1855–8
   PubMed Web of Science ®Google Scholar
• Gammelgaard B, Hansen HR, Stürup S, Møller C. (2008). The use of inductively coupled plasma mass spectrometry as a detector in drug metabolism studies. Expert Opinion Drug Met Toxicol 4:1187–207
   PubMed Web of Science ®Google Scholar
• Gika HG, Theodoridou A, Michopoulos F, et al. (2009). Determination of two COX-2 inhibitors in serum and synovial fluid of patients with inflammatory arthritis by ultra performance liquid chromatography-inductively coupled plasma mass spectrometry and quadrupole time-of-light mass spectrometry. J Pharm Biomed Anal 49:579–86
   PubMed Web of Science ®Google Scholar
• Major H, Castro-Perez J, Nicholson JK, Wilson ID. (2003a). Characterisation of putative pentose-containing conjugates as minor metabolites of 4-bromoaniline present in the urine of rats following intraperitoneal administration. Rapid Comm Mass Spect 17:76–80
   PubMed Web of Science ®Google Scholar
• Major H, Castro-Perez J, Nicholson JK, Wilson ID. (2003b). Detection of mono- and di-hexoses as metabolites of 4-bromoaniline using HPLC-TOF-MS/MS. Xenobiotica 33:855–69
   PubMed Web of Science ®Google Scholar
• Marshall P, Heudi O, Mckeown S, et al. (2002). Study of bradykinin metabolism in human and rat plasma by liquid chromatography with inductively coupled plasma mass spectrometry and orthogonal acceleration time-of-flight mass spectrometry. Rapid Comm Mass Spect 16:220–8
   PubMed Web of Science ®Google Scholar
• Meermann B, Bockx M, Laenen A, et al. (2012). Speciation analysis of bromine-containing drug metabolites in faeces samples from a human in vivo study by means of HPLC/ICP-MS combined with on-line isotope dilution. Anal Bioanal Chem 402:439–48
   PubMed Web of Science ®Google Scholar
• Nicholson JK, Lindon JC, Scarfe G, et al. (2000). High-performance liquid chromatography and inductively coupled plasma mass spectrometry (HPLC-ICP-MS) for the analysis of xenobiotic metabolites in rat urine: application to the metabolites of 4-bromoaniline. Analyst 125:235–6
   PubMed Web of Science ®Google Scholar
• Nicholson JK, Lindon JC, Scarfe GB, et al. (2001). High performance liquid chromatography linked to inductively coupled plasma spectrometery and orthogonal acceleration time-of-flight mass spectrometry for the simultaneous detection and identification of the metabolites of 2-bromo-4-trifluoromethyl-[13c]-acetanilide in the rat. Anal Chem 73:1491–4
   PubMed Web of Science ®Google Scholar
• Packert Jensen B, Smith CJ, Wilson ID, Weidolf L. (2004a). Sulphur specific detection of omeprazole metabolites in urine by high performance liquid chromatography/inductively coupled plasma mass spectrometry. Rapid Comm Mass Spectrom 18:181–3
   PubMed Web of Science ®Google Scholar
• Packert Jensen B, Smith CJ, Bailey C, et al. (2004b). Application of inductively coupled plasma mass spectrometry and high-performance liquid chromatography – with parallel electrospray mass spectrometry to the investigation of the disposition and metabolic fate of 2-, 3- and 4-iodobenzoic acids in the rat. J Chromatogr B 809:279–85
   PubMed Web of Science ®Google Scholar
• Packert Jensen B, Smith CJ, Bailey CJ, et al. (2005). Investigation of the metabolic fate of 2-,3- and 4-bromobenzoic acids in bile-duct cannulated rats by inductively coupled plasma mass spectrometry and high-performance liquid chromatography/inductively coupled plasma mass spectrometry/electrospray mass spectrometry. Rapid Commun Mass Spectrom 19:519–24
   PubMed Web of Science ®Google Scholar
• Scarfe GB, Wilson ID, Warne MA, et al. (2002a). Structure-metabolism relationships of substituted aniline: prediction of N-acetylation and N-oxanilic acid formation using computational chemistry. Xenobiotica 32:267–77
   PubMedGoogle Scholar
• Scarfe GB, Nicholson JK, Lindon JC, et al. (2002b). Identification of the urinary metabolites of 4-bromoaniline and 4-bromo-[carbonyl-13C]-acetanilide in rat. Xenobiotica 32:325–37
   PubMedGoogle Scholar
• Smith CJ, Shillingford S, Edge AM, et al. (2008). Quantification of the in vitro and in vivo metabolic fates of 2-, 3- and 4-bromobenzoic acids using high temperature LC coupled to ICP-MS and linear ion trap MS. Chromatographia 67:673–8
   Web of Science ®Google Scholar