Xenobiotica, Volume 45, Issue 8 (2015)

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Xenobiotica, Volume 45, Issue 8 (2015)

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General Xenobiochemistry

Article
Establishment of pharmacophore and VolSurf models to predict the substrates of UDP-glucuronosyltransferase1A3
Zhufeng Wu, Xingwang Zhang, Zhiguo Ma & Baojian Wu
Pages: 653-662
Published online: 02 Apr 2015
AbstractforEstablishment of pharmacophore and VolSurf models to predict the substrates of UDP-glucuronosyltransferase1A3 | Full Text | References | PDF (1,021.7 KB) | Supplemental
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Clinical Pharmacokinetics and Metabolism

Article
Pharmacokinetics, pharmacodynamics and food effect of LB30870, a novel direct thrombin inhibitor, after single oral doses in healthy men
John Kim, Sung-Hack Lee, Malcolm Boyce, Steve Warrington, Kwan Hyung Cho, Suk Kyoon Yoon, Hee Dong Park & Aeri Kim
Pages: 663-671
Published online: 12 Feb 2015
AbstractforPharmacokinetics, pharmacodynamics and food effect of LB30870, a novel direct thrombin inhibitor, after single oral doses in healthy men | Full Text | References | PDF (752.8 KB)
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Animal Pharmacokinetics and Metabolism

Article
The metabolism of 4-bromoaniline in the bile-cannulated rat: application of ICPMS (79/81Br), HPLC-ICPMS & HPLC-oaTOFMS
Catherine Duckett, Michael McCullagh, Christopher Smith & Ian D Wilson
Pages: 672-680
Published online: 02 Apr 2015
AbstractforThe metabolism of 4-bromoaniline in the bile-cannulated rat: application of ICPMS (79/81Br), HPLC-ICPMS & HPLC-oaTOFMS | Full Text | References | PDF (813.1 KB)
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Open Access
Article
Pharmacokinetics and metabolism of AMG 232, a novel orally bioavailable inhibitor of the MDM2–p53 interaction, in rats, dogs and monkeys: in vitro–in vivo correlation
Qiuping Ye, Min Jiang, Wotang T. Huang, Yun Ling, Steven H. Olson, Daqing Sun, Guifen Xu, Xuelei Yan, Bradley K. Wong & Lixia Jin
Pages: 681-692
Published online: 23 Mar 2015
AbstractforPharmacokinetics and metabolism of AMG 232, a novel orally bioavailable inhibitor of the MDM2–p53 interaction, in rats, dogs and monkeys: in vitro–in vivo correlation | Full Text | References | PDF (642.9 KB)
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Article
In vitro and in vivo metabolism of CHF 6001, a selective phosphodiesterase (PDE4) inhibitor
Valentina Cenacchi, Rosangela Battaglia, Flavio Cinato, Benedetta Riccardi, Daniele Spinabelli, Giandomenico Brogin, Paola Puccini & Daniele Pezzetta
Pages: 693-710
Published online: 03 Mar 2015
AbstractforIn vitro and in vivo metabolism of CHF 6001, a selective phosphodiesterase (PDE4) inhibitor | Full Text | References | PDF (2.9 MB)
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Article
Metabolic disposition of the anti-cancer agent [14C]laromustine in male rats
Ala F. Nassar, Adam Wisnewski & Ivan King
Pages: 711-721
Published online: 23 Mar 2015
AbstractforMetabolic disposition of the anti-cancer agent [14C]laromustine in male rats | Full Text | References | PDF (905.6 KB)
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Xenobiotic transporters

Article
Transport of trans-tiliroside (kaempferol-3-β-D-(6″-p-coumaroyl-glucopyranoside) and related flavonoids across Caco-2 cells, as a model of absorption and metabolism in the small intestine
Zijun Luo, Michael R. A. Morgan & Andrea J. Day
Pages: 722-730
Published online: 12 Mar 2015
AbstractforTransport of trans-tiliroside (kaempferol-3-β-D-(6″-p-coumaroyl-glucopyranoside) and related flavonoids across Caco-2 cells, as a model of absorption and metabolism in the small intestine | Full Text | References | PDF (597.6 KB)
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Article
Combined effect of rifampicin-induced P-glycoprotein expression and lipopolysaccharide-induced intestinal sepsis on the effective permeability and pharmacokinetics of an anti-malarial candidate CDRI 97/78 in rats
Yeshwant Singh, Mahendra Kumar Hidau, Jampala Krishna & Shio Kumar Singh
Pages: 731-740
Published online: 23 Mar 2015
AbstractforCombined effect of rifampicin-induced P-glycoprotein expression and lipopolysaccharide-induced intestinal sepsis on the effective permeability and pharmacokinetics of an anti-malarial candidate CDRI 97/78 in rats | Full Text | References | PDF (1.5 MB)
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Article
In vitro effects of standardized extract of Bacopa monniera and its five individual active constituents on human P-glycoprotein activity
Rajbir Singh, Ramakrishna Rachumallu, Manisha Bhateria, Jagadeesh Panduri & Rabi Sankar Bhatta
Pages: 741-749
Published online: 14 Apr 2015
AbstractforIn vitro effects of standardized extract of Bacopa monniera and its five individual active constituents on human P-glycoprotein activity | Full Text | References | PDF (629.5 KB) | Supplemental
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