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Xenobiotica
the fate of foreign compounds in biological systems
Volume 46, 2016 - Issue 9
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General Xenobiochemistry

Evaluation of cytochrome P450 inductions by anti-epileptic drug oxcarbazepine, 10-hydroxyoxcarbazepine, and carbamazepine using human hepatocytes and HepaRG cells

Ikuo SugiyamaDepartment of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan, ;Drug Metabolism and Pharmacokinetics, Novartis Pharma K.K., Tokyo, Japan, Correspondence[email protected]
,
Norie MurayamaLaboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Tokyo, Japan, and
,
Ayaka KurokiDepartment of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan,
,
Jagannath KotaDrug Metabolism and Pharmacokinetics, Novartis Institutes for Biomedical Research, Hyderabad, Andhra Pradesh, India
,
Shunsuke IwanoDrug Metabolism and Pharmacokinetics, Novartis Pharma K.K., Tokyo, Japan, ;Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Tokyo, Japan, and
,
Hiroshi YamazakiLaboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Tokyo, Japan, and
&
Takashi HirotaDepartment of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan,
show all
Pages 765-774 | Received 08 Sep 2015, Accepted 08 Nov 2015, Published online: 29 Dec 2015

References

  • Aninat C, Piton A, Glaise D, et al. (2006). Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells. Drug Metab Dispos 34:75–83
  • Bertilsson L, Tomson T. (1986). Clinical pharmacokinetics and pharmacological effects of carbamazepine and carbamazepine-10,11-epoxide. An update. Clin Pharmacokinet 11:177–98
  • Bring P, Ensom MH. (2008). Does oxcarbazepine warrant therapeutic drug monitoring? A critical review. Clin Pharmacokinet 47:767–78
  • European Medicines Agency. Guideline on the investigation of drug interactions. Available from: http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2012/07/WC500129606.pdf [last accessed 22 Aug 2015]
  • Flesch G. (2004). Overview of the clinical pharmacokinetics of oxcarbazepine. Clin Drug Investig 24:185–203
  • Gerets HH, Tilmant K, Gerin B, et al. (2012). Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins. Cell Biol Toxicol 28:69–87
  • Guillouzo A, Corlu A, Aninat C, et al. (2007). The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics. Chem Biol Interact 168:66–73
  • Jossé R, Aninat C, Glaise D, et al. (2008). Long-term functional stability of human HepaRG hepatocytes and use for chronic toxicity and genotoxicity studies. Drug Metab Dispos 36:1111–18
  • Kanebratt KP, Andersson TB. (2008a). HepaRG cells as an in vitro model for evaluation of cytochrome P450 induction in humans. Drug Metab Dispos 36:137–45
  • Kanebratt KP, Andersson TB. (2008b). Evaluation of HepaRG cells as an in vitro model for human drug metabolism studies. Drug Metab Dispos 36:1444–52
  • Leinonen E, Lepola U, Koponen H. (1996). Substituting carbamazepine with oxcarbazepine increases citalopram levels. A report on two cases. Pharmacopsychiatry 29:156–8
  • Luo G, Cunningham M, Kim S, et al. (2002). CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes. Drug Metab Dispos 30:795–804
  • May TW, Korn-Merker E, Rambeck B. (2003). Clinical pharmacokinetics of oxcarbazepine. Clin Pharmacokinet 42:1023–42
  • Patsalos PN. (2013). Antiepileptic drug interactions – a clinical guide. London: Springer
  • Rosaria Muscatello M, Pacetti M, Cacciola M, et al. (2005). Plasma concentrations of risperidone and olanzapine during coadministration with oxcarbazepine. Epilepsia 46:771–4
  • Spina E, Pisani F, Perucca E. (1996). Clinically significant pharmacokinetic drug interactions with carbamazepine. An update. Clin Pharmacokinet 31:198–214
  • St Louis EK. (2009). Monitoring antiepileptic drugs: a level-headed approach. Curr Neuropharmacol 7:115–19
  • Yajima K, Uno Y, Murayama N, et al. (2014). Evaluation of 23 lots of commercially available cryopreserved hepatocytes for induction assays of human cytochromes P450. Drug Metab Dispos 42:867–71

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