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Xenobiotica
the fate of foreign compounds in biological systems
Volume 17, 1987 - Issue 3
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Original Article

Pharmacological significance of the species differences in bupropion metabolism

Richard M. Welch The Wellcome Research Laboratories, 3030 Cornwallis Road, Research Triangle Park, NC, 27560, USA
,
Allen A. Lai The Wellcome Research Laboratories, 3030 Cornwallis Road, Research Triangle Park, NC, 27560, USA
&
David H. Schroeder The Wellcome Research Laboratories, 3030 Cornwallis Road, Research Triangle Park, NC, 27560, USA
Pages 287-298 | Published online: 30 Sep 2009

References

  • Butz R. F., Schroeder D. H., Welch R. M., Metha N. B., Phillips A. P., Findlay J. W. A. Radioimmunoassay and pharmacokinetic profile of bupropion in the dog. The Journal of Pharmacology and Experimental Therapeutics 1981; 217: 602–610
  • Butz R. F., Welch R. M., Findlay J. W. A. Relationship between bupropion disposition and dopamine uptake inhibition in rats and mice. The Journal of Pharmacology and Experimental Therapeutics 1982; 221: 676–685
  • Cooper T. B., Suckow R. F., Glassman A. Determination of bupropion and its major basic metabolites in plasma by liquid chromatography with dual-wavelength ultraviolet detection. Journal of Pharmaceutical Sciences 1984; 73: 1104–1107
  • Ferris R. M., White H. L., Cooper B. R., Maxwell R. A., Tang F. L. M., Beaman O. J., Russell A. Some neurochemical properties of a new antidepressant, bupropion hydrochloride (Wellbutrinr`). Drug Development Research 1981; 1: 21–35
  • Findlay J. W. A., Van Wyck Fleet J., Smith P. G., Butz R. F., Hinton M. L., Blum M. R., Schroeder D. H. Pharmacokinetics of bupropion, a novel antidepressant agent, following oral administration to healthy subjects. European Journal of Clinical Pharmacology 1981; 21: 127–135
  • Gibaldi M. Pharmacokinetics. Biopharmaceutics and Clinical Pharmacokinetics, 3rd ed., M. Gibaldi. Lea & Febiger, Philadelphia 1984; 10
  • Hinton M. L., Schroeder D. H., Smith P. G., Kersh R. D., Pillow E. M., Brent D. A., Welch R. M. Metabolism and disposition of 14C-bupropion in rats. Pharmacologist 1980; 22: 188
  • Maxwell R. A., Mehta N. B., Tucker W. E., Jr., Schroeder D. H., Stern W. C. Bupropion. Pharmacological and Biochemical Properties of Substances, E. Goldberg Morton. American Pharmaceutical Association, Washington, DC 1981; Vol. 3: 1–55
  • Mehta N. B. U.S. Patents. 3,819,706, 1974, (June 25, 1974); 3,885,046 (May 20, 1975) Burroughs Wellcome Co., Wellbutrinr` Brand bupropion hydrochloride (BW 323U)
  • Schroeder D. H., Eiseman J. L., Mehta N. B., Brent D. A., Soroko F. E., Welch R. M. The isolation and identification of some basic urinary metabolites of bupropion HCI in man. Pharmacologist 1979; 21: 191
  • Schroeder D. H. Metabolism and kinetics of bupropion. Journal of Clinical Psychiatry 1983; 44(5)79–81, Sec. 2
  • Smith P. G., Hinton M. L., Fleck R. J., Sieg J. W., Batenhorst R. L., Foster T. S., Welch R. M., Schroeder D. H. Metabolism and excretion of 14C-bupropion HCI in humans. Federation Proceedings 1980; 40: 635
  • Soroko F. E., Maxwell R. A. The pharmacologic basis for therapeutic interest in bupropion. Journal of Clinical Psychiatry 1983; 44(5)67–73, Sec. 2
  • Soroko F. E., Mehta N. B., Maxwell R. A., Ferris R. M., Schroeder D. H. Bupropion hydrochloride ((± α-t-butylamino-3-chloropropiophenone·HCI): a novel antidepressant agent. Journal of Pharmacy and Pharmacology 1977; 29: 767–770

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