Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 17, 1987 - Issue 10
135
Views
86
CrossRef citations to date
0
Altmetric
Original Article

The metabolic disposition of [methoxy-14C]-labelled trans-anethole, estragole and p-propylanisole in human volunteers

, , , &
Pages 1223-1232 | Received 15 Dec 1986, Published online: 30 Sep 2009

References

  • Drinkwater N. R., Miller E. C., Miller J. A., Pitot H. C. Hepatocarcinogenicity of estragole (1-allyl-4-methoxy-benzene) and 1′-hydroxyestragole in the mouse and mutagenicity of 1′-acetoxyestragole in bacteria. Journal of the National Cancer Institute 1976; 57: 1323–1331
  • Flavor and Extract Manufacturers' Association. Scientific Literature Review of Anisole and Derivatives in Flavor Usage. F.E.M.A., Washington, D.C. 1978
  • Le Bourhis B. Proprietes biologique de trans-anethole. Essai de determination de la dose journaliere acceptable. Parfums, Cosmetiques et Savons de France 1973; 3: 450
  • Leung A. Y. Encyclopaedia of Common Natural Ingredients used in Food, Drugs and Cosmetics. John Wiley & Sons, New York 1980
  • Miller E. C., Swanson A. B., Phillips D. H., Fletcher T. L., Liem A., Miller J. A. Structure-activity studies of the carcinogenicities in the mouse and rat of some naturally occurring and synthetic alkenylbenzene derivatives related to safrole and estragole. Cancer Research 1983; 43: 1124–1134
  • Passmore R. A Companion to Medical Studies, Volume 1, R. Passmore, J. S. Robson. Blackwell Scientific, Oxford 1968; 5.26
  • Phillips D. H., Miller J. A., Miller E. C., Adams B. Structures of the DNA adducts formed in mouse liver after administration of the proximate hepatocarcinogen 1′-hydroxyestragole. Cancer Research 1981; 41: 176–186
  • Sangster S. A., Caldwell J., Hutt A. J., Smith R. L. The metabolism of p-propylanisole in the rat and mouse and its variation with dose. Food and Chemical Toxicology 1983; 21: 263–271
  • Sangster S. A., Caldwell J., Smith R.L., Farmer P. B. Metabolism of anethole. I. Pathways of metabolism in the rat and mouse. Food and Chemical Toxicology 1984a; 22: 695–706
  • Sangster S. A., Caldwell J., Smith R. L. Metabolism of anethole. II. Influence of dose size on the route of metabolism of trans-anethole in the rat and mouse. Food and Chemical Toxicology 1984b; 22: 707–713
  • Zangouras A., Caldwell J., Hutt A. J., Smith R. L. Dose-dependent conversion of estragole in the rat and mouse to the carcinogenic metabolite 1′-hydroxyestragole. Biochemical Pharmacology 1981; 30: 1383–1386
  • Zangouras A. Metabolic studies in the assessment of the human carcinogenic hazard of estragole. 1931, Ph.D. Thesis, University of London

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.