Metabolism of flumecinol in humans

References

• Bendzko P., Vereczkey L., Fridrich J., Schwarze W., Ruckpaul K. Effect of flumecinol on the induction of cytochrome P-450 in rats and rabbits. Cytochrome P-450, Biochemistry, Biophysics and Induction, L. Vereczkey, K. Magyar. Akadémiai Kiadó, Budapest 1985; 261–268, Amsterdam: Elsevier)
   Google Scholar
• Gachályi B., Káldor A., Szeberenyi Sz. m-Ttifluoromethyl-α-ethylbenzhydrol a new enzyme inducer. European Journal of Clinical Pharmacology 1978; 13: 299–302
   PubMed Web of Science ®Google Scholar
• Gachályi B. Clinical experiences with 3-trifluoromethyl-alpha-ethylbenzhydrol (Zixorynr`), a hepatic mcirosomal enzyme inducing agent. Cytochrome P-450, Biochemistry, Biophysics and Induction, L. Vereczkey, K. Magyar. Akadémiai Kiadó, Budapest 1985; 269–271, Amsterdam: Elsevier)
   Google Scholar
• Gács I., Vargay Z., Dobis E., Dombi S., Payer K., Ótvós L. A new automatic combustion method for the liquid scintillation assay of tritium and carbon-14 in single or dual labelled materials. Journal Radioanal Chemistry 1982; 68: 93–105
   Google Scholar
• Jalsovszky G., Holly S., Klebovich I., Vereczkey L., Tóth E. Infrared spectra of the trimethylsilyl derivatives of biological molecules. A GC-IR study. Spectroscopy of Biological Molecules, A. J. P. Alix, L. Bernard, M. Manfait. John Wiley and Sons, Chichester, New York, Brisbane. Toronto, Singapore 1985; 60–62
   Google Scholar
• Kapás M., Klebovich I., Vereczkey L. “Investigation of protein binding of Zixoryn”. 4th Symposium on Biopharmaceutics and Pharmacokinetics. 1982; 36, Ştrebske Pleso, Czechoslovakia, May 24–27, Abstracts, p.
   Google Scholar
• Klebovich I., Vereczkey L., Kerpel-Fronius S., Ringwald G., Bodrogligeti I. Pharmacokinetic studies of flumecinol in man and dog. European Journal of Drug Metabolism and Pharmacokinetics 1982; 7: 99–104
   PubMedGoogle Scholar
• Klebovich I., Kapás M., Vereczkey L. Capillary gas chromatographic method for determination of flumecinol in plasma and saliva. Journal of Chromatography (Biomedical Applications) 1983; 273: 207–212
   PubMedGoogle Scholar
• Klebovich I., Mák M., Tamás J., Tóth E., Vereczkey L. Structure elucidation of human flumecinol metabolites. 1985; 33, In ISSX First European Symposium on Foreign Compound Metabolism, Malta, February 24-March 3., Abstracts, p.
   Google Scholar
• Klebovich I., Vereczkey L. Comparative pharmacokinetic study of flumecinol in rats, dogs, pigs and humans. 2. Reinfensteiner Symposium Cytochrom P-450 und Xenobiotika. 1986a; 19, Reifenstein, G.D.R., May 21–24, Abstracts, p.
   Google Scholar
• Klebovich I., Mák M., Tamás J., Vereczkey L. 1-[3-Trifluoromethyl-phenyl]-1-[5, 6-dihydroxy-cyclohexa-diene-2-yl] propane-1-ol, a new metabolite of flumecinol in humans. Advances in Pharmacology Research and Practice, K. Kelemen, J. Knoll. Akadémiai Kiadó, Budapest 1986b; 453–457, Oxford: Pergamon Press), Vol. II.
   Google Scholar
• Klebovich I., Csetényi J., Kerpel-Fronius S., Vereczkey L. Pharmacokinetic studies of 14C-labelled flumecinol in humans. Arzneimittel-Forschung (Drug Research) 1987; 37: 368
   PubMedGoogle Scholar
• Korányi Gy., Boross G. Enzyminduktive Wirkung des Zixoryn (3-Trifluoromethyl-alfa-äthyl-benzhydrol) in dem Neugeboren-Ikterus. Montsschr Kinderheilkd 1985; 133: 99–101
   PubMedGoogle Scholar
• Kulcsár-Gergely J., Kulcsár A. Hormonal environment and age influencing the activity of flumecinol, a synthetic enzyme inducer. Arzneimittel-Forschung (Drug Research) 1981; 31: 2101–2103
   PubMedGoogle Scholar
• Ledniczky M., Szinai I., Ujszászi K., Holly S., Kemény V., Mádi Gy., Ötvös L. Metabolism of 14C-3-trifluoromethyl-α-ethylbenzhydrol in rats. Arzneimittel-Forschung (Drug Research) 1978; 28: 673–677
   PubMedGoogle Scholar
• Pálosi É., Szeberényi Sz., Szporny L. Effects of 3-trifluoro-methyl-α-ethylbenzhydrol (RGH-3332), a new enzyme inducer on the central nervous system of rats, Part II. Arzneimittel-Forschung (Drug Research) 1978; 28: 669–679
   PubMedGoogle Scholar
• Pap A. Analyse de pinduciton des enzymes microsomiales par le 3-trifluométhyle-alpha-éthyle-benzhydrol. Thérapie 1979; 34: 635–640
   PubMedGoogle Scholar
• Szeberényi Sz., Pálosi É., Szporny L. Effects of 3-trifluoro-methyl-α-ethylbenzhydrol (RGH-3332), a new enzyme inducer, on the microsomal drug metabolism, Part I. Arzneimittel-Forschung (Drug Research) 1978; 28: 663–668
   PubMedGoogle Scholar
• Szeberényi Sz. Pharmacology of flumeminol (Zixoryn), a drug acting through the induction of liver cytochrome P-450 system. Cytochrome P-450, Biochemistry, Biophysics and Inductions, L. Vereczkey, K. Magyar. Akadémiai Kiadó, Budapest 1985; 253–259, Amsterdam: Elsevier)
   Google Scholar
• Tamás J., Mak M., Klebovich I., Vereczkey L., Tóth E. Mass spectrometric characterization of some human Metabolites of flumecinol. 1987, Biomedical Environmental Mass Spectrometry (in press)
   Google Scholar
• Tóth E., Tórley J., Szeberényi Sz., Pálosi É., Szporny L., Görög S., Mészáros Cs. New α-substituted benzhydrol derivatives and a process for the preparation hereof. 1977; 1–21, British Patent Specification No. 1478185
   Google Scholar
• Varadi A. 3-Trifluoromethyl-α-ethylbenzhydrol (RGH-3332), liver enzyme induction and D-glucaric acid excretion. Arzneimittel-Forschung (Drug Research) 1978; 28: 678–679
   PubMedGoogle Scholar
• Vereczkey L., Simonyi M., Fitos J., Visy J. Lack of interaction in the protein binding of flumecinol and bilirubin in human plasma. 1986; 18, in 2. Reifensteiner Symposium Cytochrom P-450 und Xenobiotika, Reinfenstein, G.D.R., May 21–24, Abstracts, p.
   Google Scholar
• Vezekényi Z., Ferenci J., Radnai B., Horváth T., Past T., Nagy L., Jávor T. Human tolerance of flumecinol (Zixoryn®, RGH-3332), its regime and dosage in healthy volunteers. International Journal of Clinical Pharmacology Research 1983; 3: 77–88
   PubMedGoogle Scholar