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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 4
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Original Article

Disposition in male volunteers of a subanaesthetic intravenous dose of an oil in water emulsion of 14C-propofol

P. J. Simons Safety of Medicines Department, Pharmaceuticals Division, Imperial Chemical Industries PLC, Alderley Park, Macclesfield, Cheshire, UK
,
I. D. Cockshott Safety of Medicines Department, Pharmaceuticals Division, Imperial Chemical Industries PLC, Alderley Park, Macclesfield, Cheshire, UK
,
E. J. Douglas Safety of Medicines Department, Pharmaceuticals Division, Imperial Chemical Industries PLC, Alderley Park, Macclesfield, Cheshire, UK
,
E. A. Gordon Safety of Medicines Department, Pharmaceuticals Division, Imperial Chemical Industries PLC, Alderley Park, Macclesfield, Cheshire, UK
,
K. Hopkins Safety of Medicines Department, Pharmaceuticals Division, Imperial Chemical Industries PLC, Alderley Park, Macclesfield, Cheshire, UK
&
M. Rowland Medical Department, Medeval Ltd, Coupland III Building, Oxford Road, Manchester, UK; University of Manchester, Oxford Road, Manchester, UK
Pages 429-440 | Received 15 Apr 1987, Accepted 13 Nov 1987, Published online: 30 Sep 2009

References

  • Adam H. K., Glen J. B., Hoyle P. A. Pharmacokinetics in laboratory animals of ICI 35,868, a new i.v. anaesthetic agent. British Journal of Anaesthesia 1980; 52: 743–746
  • Adam H. K., Kay B., Douglas E. J. Blood disoprofol levels in anaesthetised patients: correlation of concentrations after single or repeated doses with hypnotic activity. Anaesthesia 1982; 37: 536–540
  • Adam H. K., Briggs L. P., Bahar M., Douglas E. J., Dundee J. W. Pharmacokinetic evaluation of ICI 35,868 in man: single induction doses with different rates of injection. British Journal of Anaesthesia 1983; 55: 97–102
  • Cockshott I. D. Propofol (Diprivan) pharmacokinetics and metabolism—an overview. Postgraduate Medical Journal 1985; 61(Supplement 3)45–50
  • Cockshott I. D., Briggs L. P., Douglas E. J., White M. Pharmacokinetics of propofol in female patients: studies using single bolus injections. British Journal of Anaesthesia 1987, In Press
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  • Kay N. H., Sear J. W., Uppington J., Cockshott I. D., Douglas E. J. Disposition of propofol in patients undergoing surgery: a comparison in men and women. British Journal of Anaesthesia 1986; 58: 1075–1079
  • Major E., Aun C., Yate P. M., Savege T. M., Verniquet A. J. W., Adam H. K., Douglas E. J. Influence of sample site on blood concentrations of ICI 35,868. British Journal of Anaesthesia 1983.; 55: 371–375
  • Peak C. C., Beal S. L., Sheiner L. B., Nichols A. I. Extended least squares nonlinear regression: a possible solution to the -choice of weights' problem in analysis of individual pharmacokinetic data. Journal of Pharmacokinetics and Biopharmaceutics 1984; 12: 545–558
  • Plummer G. F. An improved method for the determination of propofol using hplc and fluorescence. Journal of Chromatography, Biomedical Applications 1987; 421: 171–176
  • Rhodes C., Longshaw S. Autoradiographic distribution study of a short acting anaesthetic ICI 35,868. Acta Pharmacologica et Toxicologica 1977; 41(Supplement 1)132–133
  • Sheiner L. B. Elsfit: a program for the extended least squares fit to pharmacokinetic data. School of Medicine, Department of Laboratory Medicine, University of California. 1983, Presented at the Workshop in Advanced Methods in Pharmacokinetics, St Moritz, April 10–15
  • Simons P. J., Cockshott I. D., Douglas E. J., Gordon E. A., Hopkins K., Rowland M. Blood concentrations, metabolism and elimination after a subanaesthetic intravenous dose of 14C-propofol (Diprivan) to male volunteers. Postgraduate Medical Journal 1985; 61(Supplement 3)64
  • Smith I. Chromatographic and electrophoretic techniques, Ivor Smith. William Heinemann Medical Books Ltd., Pitman Press, BathGreat Britain 1969; Volume 1

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