Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 6
49
Views
13
CrossRef citations to date
0
Altmetric
Original Article

Nephrotoxicity: A rational approach to target cell injury in vitro in the kidney

&
Pages 685-698 | Published online: 30 Sep 2009

References

  • Acara M. Effect of ethanol on the renal excretion and metabolism of choline in the isolated perfused rat kidney. Drug Metabolism and Disposition 1979; 7: 113–117
  • Alcorn D., Emslie K. R., Ross B. D., Ryan G. B., Tange J. D. Selective distal nephron damage during isolated kidney perfusion. Kidney International 1981; 9: 638–647
  • Bach P. H. The detection of chemically induced renal injury, the cascade of degenerative morphological and functional changes that follow the primary nephrotoxic insult and the evaluation of these changes by in vitro methods. Toxicology Letters 1988, in press
  • Bach P. H., Lock E. A. The use of renal tissue slices, perfusion and infusion techniques to assess renal function and malfunction. Nephrotoxicity: Assessment and Pathogenesis, P. H. Bach, F. W. Bonner, J. W. Bridges, E. A. Lock. Wiley, Chichester 1982; 128–143
  • Bach P. H., Bridges J. W. The role of prostaglandin synthetase mediated metabolic activation of analgesics and non-steroidal anti-inflammatory drugs in the development of renal papillary necrosis and upper urothelial carcinoma. Prostaglandins Leukotrienes and Medicine 1984; 15: 251–274
  • Renal Heterogeneity and Target Cell Toxicity, P. H. Bach, E. A. Lock. Wiley, Chichester 1985
  • Bach P. H., Bridges J. W. Chemically induced renal papillary necrosis and upper urothelial carcinoma. CRC Critical Reviews in Toxicology 1985; 15: 217–439
  • Bach P. H., Hardy T. L. The relevance of animal models to the study of analgesic associated renal papillary necrosis in man. Kidney International 1985; 28: 605–613
  • Nephrotoxicity: Assessment and Pathogenesis, P. H. Bach, F. W. Bonner, J. W. Bridges, E. A. Lock. Wiley, Chichester 1982
  • Bach P. H., Grasso P., Molland E. A., Bridges J. W. Changes in the medullary glycosaminoglycan histochemistry and microvascular filling during the development of 2-bromoethanamine hydrobromide-induced renal papillary necrosis. Toxicology and Applied Pharmacology 1983; 69: 333–344
  • Bach P. H., Ketley C. P., Benns S. E., Ahmed I., Dixit M. The use of isolated and cultured renal cells in nephrotoxicity—Practice, potential and problems. Renal Heterogeneity and Target Cell Toxicity, P. H. Bach, E. A. Lock. Wiley, Chichester 1985; 505–518
  • Bach P. H., Ketley C. P., Dixit M., Ahmed I. The mechanisms of target cell injury in nephrotoxicity. Food Chemical and Toxicology 1986; 24: 755–779
  • Bailie M. B., Smith J. H., Newton J. F., Hook J. B. Mechanism of chloroform nephrotoxicity. IV. Phenobarbital potentiation of in vitro chloroform metabolism and toxicity in rabbit kidneys. Toxicology and Applied Pharmacology 1984; 74: 285–292
  • Bauman A. W., Clarkson T. W., Miles E. M. Functional evaluation of isolated perfused rat kidney. Journal of Applied Physiology 1963; 18: 1239–1246
  • Baverel G., Bonnard M., D'Armagnac D E, Castanet E., Pellet M. Lactate and pyruvate metabolism in isolated renal tubules of normal dogs. Kidney International 1978; 14: 567–575
  • Beaubien A. R., Tryphonas L., Pakuts A. P., MacConaill M., Combley H. A. Liver perfusion techniques using inexpensive nonbinding medium for first-pass metabolism studies of drugs. Journal of Pharmaceutical Methods 1979; 2: 213–221
  • Belleman P. Primary monolayer cultures of liver parenchymal cells and kidney tubules as a useful new model for biochemical pharmacology and experimental toxicology. Studies in vitro on hepatic membrane transport, induction of liver enzymes and adaptive changes in renal cortical enzymes. Archives of Toxicology 1980; 44: 63–84
  • Benns S. E., Dixit M., Ahmed I., Ketley C. P., Bach P. H. The use of renal medullary cell cultures as alternatives to live animals for studying renal medullary toxicity. Alternative Methods in Toxicology, A. Goldberg. M. A. Leibert, Baltimore 1985; Volume 3: 435–447
  • Herman J., Perantoni A., Jackson H. M., Kingsbury E. Primary epithelial cell cultures of adult rat kidney, enhancement of cell growth by ammonium acetate. Experimental Cell Research 1979; 121: 47–54
  • Berndt W. O. The effect of potassium dichromate on renal tubular transport processes. Toxicology and Applied Pharmacology 1975; 32: 40–52
  • Berndt W. O. Use of renal slice technique for evaluation of renal tubular transport process. Environmental Health Perspectives 1976; 15: 73–88
  • Berndt W. O. A further characterisation of cytembena-induced nephrotoxicity. Toxicology and Applied Pharmacology 1977; 39: 207–217
  • Berndt W. O., Mehendale H. M. Effects of hexachlorobutadiene (HCBD) on renal function and renal organic ion transport in the rat. Toxicology 1979; 14: 55–65
  • Bertani T., Poggi A., Pozzoni R., Delaini F., Sacchi G., Thoua Y., Mecca G., Remuzzi G., Donati M. B. Adriamycin-induced nephrotic syndrome in rats. Laboratory Investigation 1982; 46: 16–23
  • Bohman S. O. The ultrastucture of the renal medulla and the interstitial cells. The Renal Papilla and Hypertension, A. K. Mandal, S. O. Bohman. Plenum Publishing Corp., New York 1980; 7–34
  • Carpenter H. M., Mudge G. H. Acetaminophen nephrotoxicity: Studies on renal acetylation and deacetylation. Journal of Pharmacology and Experimental Therapeutics 1981; 218: 161–167
  • Chatterjee S., Trifillis A. L., Regec A. L. Morphological and biochemical effects of gentamicin on cultured human renal tubular cells. Renal Heterogeneity and Target Cell Toxicity, P. H. Bach, E. A. Lock. Wiley, Chichester 1985; 549–552
  • Chow A. Y. K., Drummond K. N. Incorporation and hydroxylation of proline-3–4-H3 as an index of glomerular basement membrane synthesis in normal and nephrotoxic nephritic rats. Laboratory Investigation 1969; 20: 213
  • Collier V. U., Leitman P. S., Mitch W. E. Evidence forluminal uptake of gentamicin in the perfused rat kidney. Journal of Pharmacology and Experimental Therapeutics 1979; 210: 247–251
  • Dawson A. G. Preparation and some properties ot a suspension ot fragmented tubules from the rat kidney. Biochemical Journal 1972; 130: 525–532
  • Dawson A. G. Effects of acetylsalicylate on gluconeogenesis in isolated rat kidney tubules. Biochemical Pharmacology 1975; 24: 1407–1411
  • Earl L. K. Some experimental studies on mechanisms of nephrotoxicityy. Ph.D. Thesis, Univ. London. 1985
  • Elbers R., Kampffmeyer H. G., Rabes H. Effects and metabolic pathway of 4-dimethylaminophenol during kidney perfusion. Xenobiotica 1980; 10: 621–632
  • Emslie K. R., Smail M. C., Calder I. C., Hart S. J., Tange J. D. Paracetamol and the isolated perfused kidney: Metabolism and functional effects. Xenobiotica 1981; 11: 43–50
  • Epstein F. H., Brosnan J. T., Tange J. D., Ross B. D. Improved function with amino acids in the isolated perfused kidney. American Journal of Physiology 1982; 243: F284–F292
  • Foidart J. B., Deckanne C. A., Mahieu P., Creutz C. E., De Mey J. Tissue culture of normal rat glomeruli: Isolation and morphological characterization of two homogeneous cell lines. Investigative Cell Pathology 1979; 2: 15–26
  • Foidart J. B., Dubois C. H., Foidart J. M. Tissue culture of normal rat glomeruli: Basement membrane biosynthesis by homogenous epithelial and mesangial cell lines. International Journal of Biochemistry 1980; 12: 197–202
  • Foidart J. B., Dechenne C. A., Mahieu P. Tissue culture of normal rat glomeruli: Characterization of collagenous and non-collagenous basement membrane antigens on the epithelial and mesangial cells. Diagnostic Histopathology 1981; 4: 71–77
  • Franke H., Malyusz M., Runge D. Improved sodium and PAH transport in the isolated fluorocarbon-perfused rat kidney. Nephron 1978; 22: 423–431
  • Franke H., Barlow C. H., Chance B. Fluorescence of pyridine nucleotide and flavoproteins as an indicator of substrate oxidation and oxygen demand of the isolated perfused rat kidney. International Journal of Biochemistry 1980; 12: 269–275
  • Fry J. R., Perry N. K. The effect of Aroclor 1254 pretreatment on the phase I and phase II metabolism of 7-ethoxycoumarin in isolated viable rat kidney cells. Biochemical Pharmacology 1981; 30: 1197–1201
  • Fry J. R., Wiebkin P., Kao J., Jones C. A., Gwynn J., Bridges J. W. A comparison of drug-metabolising capability in isolated viable rat hepatocytes and renal tubule fragments. Xenobiotica 1978; 8: 113–120
  • Giesen-Crouse E. M., Imbs J. L., Steffan A., Schmidt M., Schwartz J. Characterization of MDCK subcultures with respect to adenyate cyclase induction. Renal Heterogeneity and Target Cell Toxicity, P. H. Bach, E. A. Lock. Wiley, Chichester 1985; 519–522
  • Hardy T. L., Bach P. H. The effects of N-phenylanthranilic acid-induced renal papillary necrosis on urinary acidification and renal electrolyte handling. Toxicology and Applied Pharmacology 1984; 75: 265–277
  • Hardy T. L. N-phenylanthranilic acid: An agent for inducing and studying renal papillary necrosis in the rat. British Journal of Experimental Pathology 1970; 51: 348–355
  • Hart S., Calder I., Ross B., Tange J. Renal metabolism of paracetamol: studies in the isolated perfused rat kidney. Clinical Science 1980; 58: 379–384
  • Herzlinger D. A., Easton T. G., Ojakian G. K. The MDCK epithelial cell line expresses a cell surface antigen of the kidney distal tubule. Journal of Cell Biology 1982; 93: 269–277
  • Hirsch G. H. Differential effects of nephrotoxic agents on renal transport and metabolism by use of in vitro techniques. Environmental Health Perspectives 1976; 15: 89–99
  • Holdsworth S. R., Glasgow E. F., Atkins R. C., Thomson N. M. Cell characteristics of cultured glomeruli from different animal species. Nephron 1978; 22: 454–459
  • Hull R. N., Cherry W. R., Weaver G. W. The origin and characteristics of a pig kidney cell strain, LLC–PK1. In Vitro 1976; 12: 670–677
  • Kacew S., Hirsch G. H. Evaluation of nephrotoxicity of various compounds by means of in vitro techniques and comparison to in vivo methods. Toxicology of the Kidney, J. B. Hook. Raven Press, New York 1981; 77–98
  • Kluwe W. M., Hook J. B. Functional nephrotoxicity of gentamicin in the rat. Toxicology and Applied Pharmacology 1978; 45: 163–175
  • Koschier F. J., Berndt W. O. Specificity of 2,4,5-trichlorophenoxyacetate on tetraethyl-ammonium transport. Toxicology and Applied Pharmacology 1976a; 38: 297–306
  • Koschier F. J., Berndt W. O. In vitro uptake of organic ions by renal cortical tissue of rats treated acutely with 2,4,5-trichlorophenoxyacetic acid. Toxicology and Applied Pharmacology 1976b; 35: 355–364
  • Koschier F. J., Berndt W. O. Relationship between 2,4,5-trichlorophenoxyacetate and the renal organic base transport system. Biochemical Pharmacology 1977; 26: 1709–1713
  • Krebs H. A., Bennett D. A. H., De Gasquet P., Gascoyne T., Yoshida T. Renal gluconeogenesis. The effects of diet on the gluconeogenic capacity of the rat kidney cortex slices. Biochemical Journal 1963; 86: 22–27
  • Kreisberg J. I., Karnovsky M. J. Glomerular cells in culture. Kidney International 1983; 23: 439–447
  • Kreisberg J. I., Pitts A. M., Pretlow T. G. Separation of proximal tubule cells from suspensions of rat kidney cells in density gradients of ficoll in tissue culture medium. American Journal of Pathology 1977; 86: 591–600
  • Kreisberg J. I., Hoover R. L., Karnovsky M. J. Isolation and characterization of rat glomerular epithelial cells in vitro. Kidney International 1978; 14: 21–30
  • Lock E. A. Renal necrosis produced by halogenated chemicals. Nephrotoxicity: Assessment and Pathogenesis, P. H. Bach, F. W. Bonner, J. W. Bridges, E. A. Lock. Wiley, Chichester 1982; 396–408
  • Lock E. A. Probenecid prevents the nephrotoxicity provoked by the N-acetyl cysteine conjugate of hexachloro-1:3-butadiene. Renal Heterogeneity and Target Cell Toxicity, P. H. Bach, E. A. Lock. Wiley, Chichester 1985; 149–152
  • Lock E. A., Ishmael J. The acute toxic effects of paraquat and diaquat on the rat kidney. Toxicology and Applied Pharmacology 1979; 50: 67–76
  • Lock E. A., Odum J., Ormond P. Transport of N-acetyl-S-pentachloro-1,3-butadienylcysteine by the renal cortex. Archives of Toxicology 1986; 15: 12–15
  • Luft F. C., Patel V., Yum M. N., Patel B., Kleit S. A. Experimental aminoglycoside nephrotoxicity. Journal of Laboratory and Clinical Medicine 1975; 86: 213–220
  • Maack T. Physiological evaluation of the isolated perfused rat kidney. American Journal of Physiology 1980; 238: F71–F78
  • Meezan E., Brendel K. Effect of ethacrynic acid on oxidative metabolism in isolated glomeruli. Journal of Pharmacology and Experimental Therapeutics 1973; 187: 352–364
  • Meisner H., Selanik P. Inhibition of renal gluconeogenesis in rats by ochratoxin. Biochemical Journal 1979; 180: 681–684
  • Mitchell C. J., Bullock S., Ross B. D. Renal handling of gentamicin and other antibiotics by the isolated perfused rat kidney: Mechanism of nephrotoxicity. Journal of Antimicrobial Chemotherapy 1977; 3: 593–600
  • Mohandas J., Duggin G. G., Horvath J. S., Tiller D. J. Metabolic oxidation of acetaminophen (paracetamol) mediated by cytochrome P-450 mixed function oxidase and prostaglandin endoperoxide synthase in rabbit kidney. Toxicology and Applied Pharmacology 1981; 61: 252–259
  • Moldeus P., Jones D. P., Ormstad K., Orrenius S. Formation and metabolism of a glutathione-S-conjugate in isolated rat liver and kidney cells. Biochemical and Biophysics Research Communications 1978; 83: 195–200
  • Moldeus P., Ormstad M., Reed D. J. Turnover of cellular glutathione in isolated rat-kidney cells. European Journal of Biochemistry 1980; 116: 13–16
  • Morita Y., Oite T., Kihara I., Yamamoto T., Hara M., Naka A., Ohno S. Culture of isolated glomeruli from normal and nephritic rabbits. I. Characterization of outgrowing cells. Acta Pathologica, Japonica 1980; 30: 917–926
  • Mudge G. H. Comparative pharmacology of the kidney: Implications for drug-induced renal failure. Nephrotoxicity: Assessment and Pathogenesis, P. H. Bach, F. W. Bonner, J. W. Bridges, E. A. Lock. Wiley, Chichester 1982; 504–518
  • Mudge G. H. Pathogenesis of Nephrotoxicity: Pharmacological principles. Renal Heterogeneity and Target Cell Toxicity, P. H. Bach, E. A. Lock. Wiley, Chichester 1985; 1–12
  • Nash J. A., King L. J., Lock E. A., Green T. The metabolism and disposition of hexachloro-1,3-butadiene in the rat and its relevance to nephrotoxicity. Toxicology and Applied Pharmacology 1984; 73: 124–137
  • Newton J. F., Hook J. B. Isolated perfused rat kidney. Methods in Enzymology 1981; 77: 94–105
  • Nishhtsutsuji-Uwo J. M., Ross B. D., Krebs H. A. Metabolic activities of the isolated perfused rat kidney. Biochemical Journal 1967; 103: 852–862
  • Nizet A. The isolated perfused kidney: Possibilities, limitations and results. Kidney International 1975; 7: 1–11
  • Ohki S., Ogino N., Yamamoto S., Hayaishi O. Prostaglandin hydroperoxidase, an integral part of prostaglandin endoperoxide synthetase from bovine vesticular gland microsomes. Journal of Biological Chemistry 1979; 254: 829–836
  • Ormstad K. Metabolism of glutathione in the kidney. Nephrotoxicity in the Experimental and the Clinical Situation, P. H. Bach, E. A. Lock. Martinus Nijhoff, Dordrecht 1987; 405–428
  • Ormstad K., Jones D. P., Orrenius S. Preparation and characterisation of isolated kidney cells. Methods in Enzymology 1981; 77: 137–146
  • Powell C. J., Adams T., Hall D. E., Bach P. H., Bridges J. W. The comparative sub-acute nephrotoxicity of diphenylamine and N-phenylanthranilic acid. Renal Heterogeneity and Target Cell Toxicity, P. H. Bach, E. A. Lock. Wiley, Chichester 1985; 199–200
  • Radda G. K., Ackerman J. J. H., Bore P., Wong C. G., Ross B. D., Green Y., Bartlett S., Lowry M. 31P NMR studies on kidney intracellular pH in acute renal acidosis. International Journal of Biochemistry 1980; 12: 277–281
  • Richardson J. C. W., Waterson P., Simmons N. L. Isolation and culture of renal cortical tubules from neonate rabbit kidneys. Quarterly Journal of Experimental Physiology 1982; 67: 287–301
  • Rosenthal A. M., Jones G., Koch S. W., Fraser D. 25-Hydroxyvitamin D3 metabolism by isolated perfused rat kidney. American Journal of Physiology 1980; 239: E12–E20
  • Ross B. D. The isolated perfused rat kidney. Clinical Science and Molecular Medicine 1978; 55: 513–521
  • Ross B. D., Bullock S. The perfused rat kidney in studies of renal metabolism and disease. Przeglad Lekarski 1977; 34: 390–398
  • Ross B. D., Tannen R. L. Effect of decrease in bicarbonate concentration on metabolism of the isolated perfused rat kidney. Clinical Science 1979; 57: 103–111
  • Ross D., Larsson R., Andersson B., Nilsson U., Lindquist T., Lindeke B., Moldeus P. The oxidation of p-phenetidine by horseradish peroxidase and prostaglandin synthase and the fate of glutathione during such oxidations. Biochemical Pharmacology 1985; 34: 343–351
  • Roth K. S., Holtzapple P., Genel M., Segal S. Uptake of glycine by human kidney cortex. Metabolism 1979; 18: 677–681
  • Rylander-Yueh L. A., Gandolfi A. J., Brendel K. Use of isolated rabbit renal tubules to examine inhibition of organic acid/base transport by toxins. Renal Heterogeneity and Target Cell Toxicity, P. H. Bach, E. A. Lock. Wiley, Chichester 1985; 531–534
  • Saier M. H. Growth and differentiated properties of a kidney epithelial cell line (MDCK). American Journal of Physiology 1981; 240: C106–C109
  • Schlondorff D., Roczniak S., Satriano J. A., Folkert V. W. Prostaglandin synthesis by isolated rat glomeruli: effect of angiotensin II. American Journal of Physiology 1980; 239: F486–F495
  • Schurek H. J., Schlatter E., Meier W., Zick R., Dorn G., Hehrmann R., Stolte E. Renal handling of polypeptide hormones (insulin, C-peptide, h-PTH) as studied in the isolated perfused rat kidney. International Journal of Biochemistry 1980; 12: 237–242
  • Slegers J. F. G., Forster M. T. G. Absence of effect of diazoxide on sodium and water handling in the isolated perfused rat kidney. Archives Internationales de Pharmacodynamie et de Therapie 1980; 244: 309–320
  • Smith J. H., Hook J. B. Mechanisms of chloroform nephrotoxicity II. In vitro evidence for renal metabolism of chloroform in mice. Toxicology and Applied Pharmacology 1983; 70: 480–485
  • Sraer J., Foidart J., Chansel D., Mahieu P., Ardaillou R. Prostaglandin synthesis by rat isolated glomeruli and glomerular cultured cells. International Journal of Biochemistry 1980; 12: 203–207
  • Sraer J., Rigaud M., Bens M., Babinovitch H., Ardaillou R. Metabolism of arachidonic acid via the lipoxygenase pathway in human and murine glomeruli. Journal of Biological Chemistry 1983; 258: 4325–4330
  • Steele J. W., Yagen B., Hernandez O., Cox R. H., Smith B. R., Bend J. R. The metabolism and excretion of styrene oxide-glutathione conjugates in the rat and by isolated perfused liver, lung and kidney preparations. Journal of Pharmacology and Experimental Therapeutics 1981; 219: 35–41
  • Striker G. E., Kllen P. D., Farin F. M. Human glomerular cells in vitro: Isolation and characterization. Transplantation Proceedings 1980; 12: 88–99
  • Stumpf B., Kraus H. Inhibition of gluconeogenesis in isolated rat kidney tubules by branched chain α-ketoacids. Pediatric Research 1978; 12: 1039–1044
  • Szefler S. J., Acara M. Isoproterenol excretion and metabolism in the isolated perfused rat kidney. Journal of Pharmacology and Experimental Therapeutics 1979; 210: 295–300
  • Tannen R. L., Ross B. D. Ammoniagenesis by the isolated perfused rat kidney: The critical role of urinary acidification. Clinical Science 1979; 56: 353–364
  • Taub M., Saier M. H. Amiloride-resistant Madin Darby canine kidney (MDCK) cells exhibit decreased cation transport. Journal of Cell Physiology 1981; 106: 191–199
  • Terao N., Tannen R. L. Characterisation of acidification by the isolated perfused rat kidney: Evidence for adaptation by the distal nephron to a high bicarbonate diet. Kidney International 1981; 20: 36–42
  • Trifillis A. L., Regec A. L., Hall-Graggs M., Trump B. F. Effects of cyclosporin on cultured human renal tubular cells. Renal Heterogeneity and Target Cell Toxicity, P. H. Bach, E. A. Lock. Wiley, Chichester 1985; 545–548
  • Wold J. S., Turnipseed S. A., Miller B. L. The effect of renal cation transport inhibition on cephaloridine nephrotoxicity. Toxicology and Applied Pharmacology 1979; 47: 115–122
  • Yerna M. J., Hartshorne D. J., Goldman R. D. Isolation and characterization of baby hamster kidney (BHK-21) cell modular protein. Biochemistry 1979; 18: 673–678
  • Zenser T. V., Mattammal M. B., Davis B. B. Differential distribution of mixed function oxidase activities in rabbit kidney. Journal of Pharmacology and Experimental Therapeutics 1978; 207: 719–725
  • Zenser T. V., Mattammal M. B., Brown W. W., Davis B. B. Cooxygenation by prostaglandin cyclooxygenase from rabbit inner medulla. Kidney International 1979; 16: 688–694
  • Zimmermann U., Scheurich P., Pilwat G., Benz R. Cells with manipulated functions: New perspective for cell biology, medicine and technology. Angewandte Chemie-International Edition in English 1981; 20: 325–344
  • Zimmermann U. Electric field-mediated fusion and related electric phenomena. Biochimica et Biophysica Acta 1982; 694: 227–277

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.