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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 12
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Original Article

Elimination and Accumulation of the Rodenticide Flocoumafen in Rats Following Repeated Oral Administration

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Pages 1465-1479 | Received 20 Dec 1987, Accepted 08 Jul 1988, Published online: 30 Sep 2009

References

  • Garforth B., Johnson R. A. Performance and safety of the new anticoagulant rodenticide flocoumafen. BCPC Monograph No. 37, Stored Products Pest Control, British Crop Protection Council, Thornton HealthUK 1987; 115–123
  • Hadler M. R., Shadbolt R. S. Novel 4‐hydroxycoumarin anticoagulants active against resistant rats. Nature 1975; 253: 275–277
  • Huckle K. R., Hutson D. H., Logan C. J., Morrison B. J., Warburton P. A. The fate of the rodenticide flocoumafen in the rat: retention and elimination of a single oral dose. Pesticide Science 1988a, in press
  • Huckle K. R., Warburton P. A., Forbes S., Logan C. J. Studies on the fate of the rodenticide flocoumafen in Japanese quail. Coturnix conturnix japonica. Xenobiotica
  • Nelsestuen G. L. Interactions of vitamin K‐dependent proteins with calcium ions and phospholipid membranes. Federation Proceedings 1978; 37: 2621–2625
  • Parmar G., Bratt H., Moore R., Batten P. L. (1987) Evidence for a common binding site in vivo for retention of anticoagulants in rat liver. Abstract of a poster paper presented at the British Toxicological Society meeting. March, 26–27th1987
  • Searcey M. T., Graves C. B., Olson R. E. Isolation of a warfarin binding protein from liver endoplasmic reticulum of Sprague‐Dawley and warfarin‐resistant rats. Journal Biological Chemistry 1977; 252: 6260–6267
  • Suttie J. W. The fat soluble vitamins. Handbook of Lipid Research, H. F. Deluca. Plenum Press, New York 1978; Vol. 2: 211–277
  • Suttie J. W. Mechanism of action of vitamin K: Synthesis of γ‐carboxyglutamic acid. Critical Reviews in Biochemistry 1980; 8: 191–223
  • Thijssen H. H. W., Baars L. G. M. Hepatic uptake and storage of warfarin. The relation with the target enzyme vitamin K 2,3‐epoxide reductase. Journal of Pharmacology and Experimental Therapeutics 1987; 243: 1082–1088

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