Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 19, 1989 - Issue 12
20
Views
8
CrossRef citations to date
0
Altmetric
Original Article

Enzymic synthesis of two glucuronides of the hydroxyisoxazole GABA-agonist, THIP, and the in vivo glucuronidation of THIP in rat

, &
Pages 1399-1406 | Received 13 Feb 1989, Accepted 05 Jul 1989, Published online: 30 Sep 2009

References

  • Akagi M., Aoki I., Uematsu T. Studies on food additives. X. The metabolism of p-ethoxyphenylurea in the rabbit. Chemical and Pharmaceutical Bulletin 1966; 14(1)1–19
  • Altona C., Haasnoot C. A. G. Prediction of anti and gauche vicinal proton-proton coupling constants in carbohydrates: a simple additivity rule for pyranose rings. Organic Magnetic Resonance 1980; 13(6)417–429
  • Ando M., Nakamura T., Nakagawa M. Metabolism of hymexazol, 3-hydroxy-5-methylisoxazole, in the rat. Agricultural and Biological Chemistry 1974; 38(12)2451–2456
  • Ando M., Nakagawa M., Nakamura T., Tomita K. Metabolism of isoxathion, O,O-diethyl O-(5-phenyl-3-isoxazolyl)-phosphorothioate in the rats. Agricultural and Biological Chemistry 1975; 39(4)803–809
  • Baraldi M., Grandison L., Guidotti A. Distribution and metabolism of muscimol in the brain and other tissues of the rat. Neuropharmacology 1979; 18: 57–62
  • Breitmaier E., Voelter W. 13C NMR spectroscopy2nd edn., H. F. Ebel. Monographs in Modern Chemistry 5, Verlag Chemie Weinheim, New York 1978
  • Funcke W., Klemer A. Notiz über die Identifizierung und Strukturaufklärung einiger Amadoriverbindungen durch 13C-NMR-Spektroskopie. Liebigs Analen der Chemie 1975; 1232–1235
  • Kasper C. B., Henton D. Glucuronidation. Enzymatic Basis of Detoxication, II, W. B. Jakoby. Academic Press, New York 1980
  • Krogsgaard-Larsen P., Falch E., Sauerberg P., Freedman S. B., Lembl H. L., Meier E. Bioisosteres of arecoline as novel CNS-active muscarinic agonists. Trends in Pharmacological Sciences February, 1988; 69–74, supplement
  • Krogsgaard-Larsen P., Schultz B., Mikkelsen H., Aaes-Jrgensen T., Bges K. P. THIP, isoguvacine oxide, and related GABA agonists. in Amino Acid Neurotransmitters, F. V. DeFeudis, P. Mandel. Raven Press, New York 1981; 69–76
  • Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. Protein measurement with the folin phenol reagent. Journal of Biological Chemistry 1951; 193: 265–276
  • Maguire J. H., Butlet T. C., Dudley K. H. 5-Ethyl-5-phenylhydantoin N-glucuronide, the major urinary metabolite of 5-ethyl-5-phenylhydantoin (Nirvanol) in the dog. Drug Metabolism and Disposition 1982; 10(6)595–598
  • Schultz B., Aaes-Jrgensen T., Bges K. P., Jrgensen A. Preliminary studies on the absorption, distribution, metabolism and excretion of THIP in animal and man using 14C-labelled compound. Acta Pharmacologica et Toxicologica 1981; 49: 7–15
  • Soine W. H., Soine P. J., Overton B. W., Garrettson L. K. Product enantioselectivity in the N-glucosylation of amobarbital. Drug Metabolism and Disposition 1986; 14(5)619–621
  • Tsukamoto H., Yoshimura H., Tatsumi K. Metabolism of drugs. XXXV. Metabolic fate of meprobamate. (3). A new metabolic pathway of carbamate group-the formation of meprobamate N-glucuronide in animal body. Chemical and Pharmaceutical Bulletin 1963; 11: 421–426

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.