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Xenobiotica
the fate of foreign compounds in biological systems
Volume 20, 1990 - Issue 12
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Original Article

A review of the clinical pharmacokinetics and metabolism of the α1-adrenoceptor antagonist indoramin

Pages 1357-1367 | Received 05 Dec 1989, Accepted 25 May 1990, Published online: 27 Aug 2009

References

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  • Archibald J. L. Some recent developments in the pharmacology and pharmacokinetics of indoramin. Journal of Cardiovascular Pharmacology 1986; 8: S16
  • Draffan G. H., Clare R. A., Williams F. W., Emons E., Jackson J. L. Applications of gas chromatography-mass spectrometry in quantitative drug and metabolite measurement. Mass Spectrometry in Biochemistry and Medicine, A. Frigerio, N. Castagnoli. Raven Press, New York 1974; 8–17
  • Draffan G. H., Lewis P. J., Firmin J. L., Jordan T. W., Dollery C. T. Pharmacokinetics of indoramin in man. British Journal of Clinical Pharmacology 1976; 3: 489–495
  • Franklin R. A., Pierce D. M. Studies on the biotransformation of indoramin in the patas monkey. Xenobiotica 1981; 11: 755–762
  • Franklin R. A., Robson P., Stevenson D. Studies on the metabolism of the new antihypertensive agent, indoramin, in man. European Journal of Clinical Pharmacology 1983; 24: 629–634
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  • Johnson E. S. Indoramin in essential hypertension. British Journal of Clinical Pharmacology 1981; 12: 401–404
  • Neumann G., Wilke G., Reimold W. V., Pierce D. M., Geising M. Pharmacokinetics of indoramin and its metabolite 6-hydroxyindoramin after single and multiple doses to cirrhotic liver patients. Journal of Cardiovascular Pharmacology 1986; 8: S20
  • Norbury H. M., Franklin R. A., Marrott P. K., Warrington S. J. Pharmacokinetics of intravenous indoramin in middle-aged male and female volunteers. European Journal of Clinical Pharmacology 1983; 25: 243–246
  • Norbury H. M., Franklin R. A., Marrott P. K., Warrington S. J. Pharmacokinetics of oral indoramin in elderly and middle-aged male and female volunteers. European Journal of Clinical Pharmacology 1984; 27: 247–249
  • Pierce D. M., Abrams S. M. L., Franklin R. A. Pharmacokinetics and systemic availability of the antihypertensive agent indoramin and its metabolite 6-hydroxyindoramin in healthy subjects. European Journal of Clinical Pharmacology 1987 a; 32: 619–623
  • Pierce D. M., Smith S. E., Franklin R. A. The pharmacokinetics of indoramin and 6-hydroxyindoramin in poor and extensive hydroxylators of debrisoquine. European Journal of Clinical Pharmacology 1987 b; 33: 59–65
  • Pierce D. M., Abrams S. M. L., Franklin R. A. Intra- and inter-subject variation in the pharmacokinetics of indoramin and its 6-hydroxylated metabolite. European Journal of Clinical Pharmacology 1988 a; 35: 195–198
  • Pierce D. M., Warrington S. M. L., Franklin R. A. Pharmacokinetics of indoramin and its 6-hydroxylated metabolite after repeated oral dosing. Biopharmaceutics and Drug Disposition 1988 b; 9: 147–157
  • Swaisland A. J. Determination of therapeutic concentrations of indoramin by liquid chromatography with fluorimetric detection. Analyst 1981; 106: 717–719
  • Volans G. N., Jeffereys D., Latham A. N., Frost T. Pharmacokinetics of oral indoramin. Current Medical Research and Opinion 1982; 8: 51–53

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