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Xenobiotica
the fate of foreign compounds in biological systems
Volume 20, 1990 - Issue 1
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Original Article

Characterization of products formed by the reaction of 14C-sulphamethazinediazonium tetrafluoroborate with natural products

G. D. Paulson Biosciences Research Laboratory, Agricultural Research Service, US Department of Agriculture, Fargo, ND, 58105, USA
&
V. J. Feil Biosciences Research Laboratory, Agricultural Research Service, US Department of Agriculture, Fargo, ND, 58105, USA
Pages 81-89 | Received 17 Apr 1989, Accepted 18 Aug 1989, Published online: 27 Aug 2009

References

  • Chin A., Hung M., Stock L. M. Reactions of benzenediazonium ions with adenine and its derivatives. Journal of Organic Chemistry 1981; 46: 2203–2207
  • Hung M., Stock L. M. Reactions of benzenediazonium ions with guanine and its derivatives. Journal of Organic Chemistry 1982; 47: 448–453
  • Kaiser D. G. Radioisotopic assay for neomycins B, C, and neamine. Analytical Chemistry 1963; 35: 552–554
  • Lower G. M., Lanphear S. P., Johnson B. M., Bryan G. T. Aryl and heterocyclic diazo compounds as potential environmental electrophiles. Journal of Toxicology and Environmental Health 1977; 2: 1095–1107
  • Mitchell A. D., Paulson G. D., Zaylskie R. G. Steady state kinetics of 14C-sulfamethazine {4-amino-N-(4,6-dimethyl-2-pyrimidinyl)benzene[U-14C]sulfonamide} metabolism in swine. Drug Metabolism and Disposition 1986; 4: 155–160
  • Paulson G. D. The effect of nitrite and nitrate on the metabolism of sulphamethazine in the rat. Xenobiotica 1986; 16: 53–61
  • Paulson G. D., Feil V. J. Evidence for diazotization of 14C-sulfamethazine {4-amino-N-(4,6-dimethyl-2-pyrimidinyl)benzene[U-14C]sulfonamide} in swine: the effect of nitrite. Drug Metabolism and Disposition 1987; 15: 841–845
  • Paulson G. D., Struble C. B. A unique deaminated metabolite of sulfamethazine {4-amino-N-(4,6-dimethyl-2-pyrimidinyl)[14C]benzenesulfonamide} in swine. Life Sciences 1980; 27: 1811–1817
  • Paulson G. D., Feil V. J., MacGregor J. T. Formation of a diazonium cation intermediate in the metabolism of sulphamethazine to desaminosulphamethazine in the rat. Xenobiotica 1987; 17: 697–707
  • Paulson G. D., Giddings J. M., Lamoureux C. H., Mansager E. R., Struble C. B. The isolation and identification of 14C-sulfamethazine {4-amino-N-(4,6-dimethyl-2-pyrimidinyl)[14C]benzenesulfonamide} metabolites in the tissues and excreta of swine. Drug Metabolism and Disposition 1981; 9: 142–146
  • Toth B., Nagel D., Ross A. Gastric tumorigenesis by a single dose of 4-(hydroxymethyl)benzenediazonium ion of Agaricus bisporus. British Journal of Cancer 1982; 46: 417–422
  • Woolley J. L., Sigel C. W. The role of dietary nitrate and nitrite in the reductive deamination of sulfadiazine by the rat, guinea pig and neonatal calf. Life Sciences 1982; 30: 2229–2234

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