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Xenobiotica
the fate of foreign compounds in biological systems
Volume 20, 1990 - Issue 4
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Research Article

Activation and detoxication of aminophenols. III. Synthesis and structural elucidation of various glutathione addition products to 1,4-benzoquinone

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Pages 351-361 | Received 15 May 1989, Accepted 15 Nov 1989, Published online: 22 Sep 2008

References

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  • Chambers J. G. Electrochemistry of quinones. The Chemistry of Quinoid Compounds, S. Patai. John Wiley, London 1974; 737–791
  • Eckert K.-G. The metabolism of aminophenols in erythrocytes. Xenobiotica 1988; 18: 1319–1326
  • Eckert K.-G., Eyer P. Differences in the reactions of isomeric ortho- and para-aminophenols with hemoglobin. Biochemical Pharmacology 1983; 32: 1019–1027
  • Eckert K.-G., Eyer P. Influence of 4-dimethylaminophenol on the glutathione status of red cells. Abstracts of North American Symposium on Risk Assessment and the Biological Fate of Xenobiotics. organized by ISSX, Key Biscayne, FLUSA 1985; 20
  • Eyer P., Kiese M. Biotransformation of 4-dimethylaminophenol: Reaction with glutathione, and some properties of the reaction products. Chemico-Biological Interactions 1976; 14: 165–178
  • Finley K. T. The addition and substitution chemistry of quinones. The Chemistry of the Quinoid Compounds. Part II, S. Patai. John Wiley, London 1974; 877–1144
  • Lau S. S., Hill B. A., Highet R. J., Monks T. J. Sequential oxidation and glutathione addition to 1,4-benzoquinone: Correlation of toxicity with increased glutathione substitution. Molecular Pharmacology 1988; 34: 829–836
  • Rossi L., Moore G. A., Orrenius S., O'Brien P. J. Quinone toxicity in hepatocytes without oxidative stress. Archives of Biochemistry and Biophysics 1986; 251: 25–35

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