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Xenobiotica
the fate of foreign compounds in biological systems
Volume 20, 1990 - Issue 4
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Research Article

Metabolism of 1,3-di-{4-[N-(4,6-dimethyl-2-pyrimidinyl)sulphamoyl]phenyl}triazene (DDPSPT) in the rat

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Pages 395-400 | Received 27 Jun 1989, Accepted 01 Dec 1989, Published online: 22 Sep 2008

References

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  • Haraguchi K., Masuda Y. Formation of triazene from sulphonamide and nitrite in acidic solution. Food Chemistry and Toxicology 1986; 24: 299–303
  • Hoogenboom L. A. P., Van der Steeg P. W., Kuiper H. A., Kramers P. G. N. In vitro formation of a triazene compound by reaction of sulphadimidine and nitrite. Food Chemistry and Toxicology 1987; 25: 373–377
  • Hoogenboom L. A. P., Pijpers A., Van de Steeg P. W., Aerts M. M. L., Verheijden J. H. M., Kuiper H. A. The effect of dietary nitrite and nitrate on the metabolism of sulphadimidine administered orally to pigs. Veterinary Quarterly 1988; 10: 136–139
  • Mitchell A. D., Paulson G. D., Zaylskie R. G. Steady state kinetics of 14C-sulfamethazine {4-amino-N-(4,6-dimethyl-2-pyrimidinyl)benzene[U-14C]sulfonamide} metabolism in swine. Drug Metabolism and Disposition 1986; 14: 155–160
  • Nomura T., Kurokawa N., Isa Y., Sakamoto Y., Kondo S., Endo H. Induction of lymphorecticular neoplasia and malformations by prenatal treatment with 1,3-di(4-sulfamoylphenyl)triazene in mice. Carcinogenesis 1984; 5: 571–575
  • Paulson G. D. The effect of dietary nitrite and nitrate on the metabolsim of sulphamethazine in the rat. Xenobiotica 1986; 16: 53–61
  • Paulson G. D., Feil V. J. Evidence for diazotization of 14C-sulfamethazine {4-amino-N-(4,6-dimethyl-2-pyrimidinyl)-benzene[U-14C]sulfonamide} in swine: the effect of nitrite. Drug Metabolism and Disposition 1987; 15: 841–845
  • Paulson G. D., Feil V. J. Characterization of products formed by the reaction of 14C-sulphamethazinediazonium tetrafluoroborate with natural products. Xenobiotica 1990; 20: 81–89
  • Paulson G. D., Giddings J. M., Lamoureux C. H., Mansager E. R., Struble C. B. The isolation and identification of 14C-sulfamethazine {4-amino-N-(4,6-dimethyl-2-pyrimidinyl) [14C]benzenesuulfonamide} metabolites in the tissues and excreta of swine. Drug Metabolism and Disposition 1981; 9: 142–146
  • Paulson G. D., Struble C., Mitchell A. (1983) Comparative metabolism of sulfamethazine [4-amino-N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide] in the rat, chicken, pig and sheep. Proceedings of Fifth International Congress of Pesticide Chemistry. 29 August-4 September, 1982, J. Miyamoto, P. C. Kearney. Pergamon Press, New York, 375–380
  • Paulson G. D., Mitchell A. D., Zaylskie R. G. Identification and quantitation of sulfamethazine metabolites by liquid chromatography and gas chromatography-mass spectrometry. Journal of the Association of Official Analytical Chemists 1985; 68: 1000–1006
  • Paulson G. D., Feil V. J., MacGregor J. T. Formation of a diazonium cation intermediate in the metabolism of sulphamethazine to desaminosulphamethazine in the rat. Xenobiotica 1987; 17: 697–707

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