Variation in drug-metabolizing enzyme activities during the growth of human Hep G2 hepatoma cells

References

• Abe S., Nemoto N., Sasaki M. Sister chromatid exchange induction by direct mutagens/carcinogens, arylhydrocarbon hydroxylase activity and benzo(a)pyrene metabolism in cultured human hepatoma cells. Mutation Research 1983; 109: 83–90
   PubMedGoogle Scholar
• Allalunis-Turner M. J., Lee F. Y. X., Siemann D. W. Comparison of glutathione levels in rodent and human tumour cells grown in vitro and in vivo. Cancer Research 1988; 48: 3657–3660
   PubMedGoogle Scholar
• Babany G., Descatoire V., Corbic M., Gendre S., Degott C., Larrey D., Letteron P., Wandscheer J.-C., Funck-Brentanoa C., Pessayre D. Regulation of renal cytochrome P450. Effects of two thirds hepatectomy, cholestasis, biliary cirrhosis and postnecrotic cirrhosis on hepatic and renal microsomal enzymes. Biochemical Pharmacology 1985; 34: 311–320
   PubMedGoogle Scholar
• Bock K. W., Bock-Henning B. S. Differential induction of human liver UDP-glucuronosyltransferase activities by phenobarbital-type inducers. Biochemical Pharmacology 1987; 36: 4137–4143
   PubMed Web of Science ®Google Scholar
• Burke M. D., Mayer R. T. Differential effects of phenobarbitone and 3-methylcholan-threne induction on the hepatic microsomal metabolism and cytochrome P450 binding of phenoxazone and a homologous series of its n-alkylethers (alkoxyresorufins). Chemico-Biological Interactions 1983; 45: 243–258
   PubMed Web of Science ®Google Scholar
• Burke M. D., Thompson S., Elcombe C. R., Halpert J., Haaparanta T., Mayer R. T. Ethoxy-, pentoxy- and benzyloxy-phenoxazones and homologues; a series of substrates to distinguish between different induced cytochromes P450. Biochemical Pharmacology 1985; 34: 3337–3345
   PubMed Web of Science ®Google Scholar
• Dansette P. M., Du Bois G. C., Jerina D. M. Continuous fluorimetric assay of epoxide hydrase activity. Analytical Biochemistry 1979; 97: 340–345
   PubMedGoogle Scholar
• Dawson J. R., Adams D. J., Wolf C. R. Induction of drug metabolising enzymes in human liver cell line Hep G2. FEBS Letters 1985; 183: 219–222
   PubMed Web of Science ®Google Scholar
• Diamond L., Kruszewski F., Aden D. P., Knowles B. B., Baird W. M. Metabolic activation of benzo(a)pyrene by a human hepatoma cell line. Carcinogenesis 1980; 1: 871–875
   PubMed Web of Science ®Google Scholar
• Doostdar H., Duthie S. J., Burke M. D., Melvin W. T., Grant M. H. The influence of culture medium composition on drug metabolising enzyme activities of human- Hep G2 cell line. FEBS Letters 1988; 241: 15–38
   PubMed Web of Science ®Google Scholar
• Dutton G. J. Principles of assay of glucuronidation in biological tissues or fluids and selected practical procedures. Glucuronidation of Drugs and Other Compounds. CRC Press, Boca Raton, FL 1980; 183–204
   Google Scholar
• Falzon M., Milton A. S., Burke M. D. Are the decreases in hepatic cytochrome P-450 and other drug-metabolising enzymes caused by indomethacin in vivo mediated by intestinal bacterial endotoxins?. Biochemical Pharmacology 1984; 33: 1285–1292
   PubMedGoogle Scholar
• Grant M. H., Hawksworth G. M. The activity of UDP-glucuronyltransferase, sul-photransferase and glutathione-S-transferase in primary culture of rat hepatocytes. Biochemical Pharmacology 1986; 35: 2979–2982
   PubMed Web of Science ®Google Scholar
• Grant M. H., Duthie S. J., Gray A. G., Burke M. D. Mixed function oxidase and UDP-glucuronyltransferase activities in the human Hep G2 hepatoma cell lines. Biochemical Pharmcology 1988; 37: 4111–4116
   PubMed Web of Science ®Google Scholar
• Grant M. H., Melvin M. A. L., Shaw P., Melvin W. T., Burke M. D. Studies on the maintenance of cytochromes P450 and b5, monooxygenases and cytochrome reductases in primary cultures of rat hepatocytes. FEBS Letters 1985; 190: 99–103
   PubMed Web of Science ®Google Scholar
• Grant M. H., Burke M. D., Hawksworth G. M., Duthie S. J., Engeset J., Petrie J. C. Human adult hepatocytes in primary monolayer culture. Maintenance of mixed function oxidase and conjugation pathways of drug metabolism. Biochemical Pharmacology 1987; 36: 2311–2316
   PubMed Web of Science ®Google Scholar
• Habig W. H., Jakoby W. B. Assays for differentiation of glutatione-S-transferases. Methods in Enzymology 1981; 77: 398–405
   PubMedGoogle Scholar
• Hissin P. J., Hilf R. A fluorimetric method for determination of oxidised and reduced glutathione in tissues. Analytical Biochemistry 1976; 74: 214–226
   PubMed Web of Science ®Google Scholar
• Huh N., Namoto N., Utakoji T. Metabolic activation of benzo(a)pyrene, aflotoxin B, and dimethylnitrosamine by a human hepatoma cell line. Mutation Research 1982; 94: 339–348
   PubMedGoogle Scholar
• Knowles B. B., Howe C. C., Aden D. P. Human hepatocellular carcinoma cell lines secrete the major plasma porteins and hepatitis B surface antigen. Science 1980; 209: 497–499
   PubMed Web of Science ®Google Scholar
• Krupski G., Kiefer F., Wiebel F. J. Variability in the expression of xenobiotic-metabolising enzymes during the growth cycle of rat hepatoma cells. Xenobiotica 1985; 15: 781–787
   PubMed Web of Science ®Google Scholar
• Limbosch S. Benzo(a)pyrene and aldrin metabolizing activities in cultured human and rat hepatoma cell lines. Journal of the National Cancer Institute 1983; 71: 281–286
   PubMed Web of Science ®Google Scholar
• Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 1951; 193: 265–275
   PubMed Web of Science ®Google Scholar
• Mackenzie P. I., Hänninen O. Sensitive kinetic'assay for UDP-glucuronyltransferase using 1-naphthol as substrate. Analytical Biochemistry 1980; 109: 362–368
   PubMed Web of Science ®Google Scholar
• Puig J. F., Tephly T. R. Isolation and purification of rat liver morphine UDP-glucuronyltransferase. Molecular Pharmacology 1986; 30: 558–565
   PubMed Web of Science ®Google Scholar
• Sassa S., Sugita O., Galbraith R. A., Kappas A. Drug metabolism by the human hepatoma cell, Hep GS. Biochemical and Biophysical Research Communications 1987; 143: 52–57
   PubMed Web of Science ®Google Scholar