Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 20, 1990 - Issue 8
163
Views
20
CrossRef citations to date
0
Altmetric
Original Article

Comparative metabolism of high doses of aspirin in man and rat

, &
Pages 847-854 | Received 11 Oct 1989, Accepted 30 Mar 1990, Published online: 27 Aug 2009

References

  • Ali B., Kaur S. Mammalian tissue acetylsalicylic acid esterases. Identification, distribution and discrimination from other esterases. Journal of Pharmacology and Experimental Therapeutics 1983; 226: 589–594
  • Bochner F., Graham G. G., Cham E., Imhoff D. M., Haavisto T. M. Salicylate metabolite kinetics after several salicylates. Clinical Pharmacology and Therapeutics 1981; 30: 266–275
  • Bochner F., Graham G. G., Polverino A., Imhoff D. M., Tregenza R. A., Rolan P. E., Cleland L. G. Salicyl phenolic gluronide pharmacokinetics in patients with rheumatoid arthritis. European Journal of Clinical Pharmacology 1987; 32: 153–158
  • Costello P. B., Caruana J. A., Green F. A. The relative roles of hydrolases of the erythrocyte and other tissues in controlling aspirin survival in vivo. Arthritis and Rheumatism 1984; 27: 422–426
  • Davis L. E., Westfall B. A. Species difference in biotransformation and excretion of salicylate. American Journal of Veterinary Research 1972; 33: 1253–1262
  • Dean M., Penglis S., Stock B. The pharmacokinetics of salicylate in the pregnant Wistar rat. Drug Metabolism and Disposition 1989; 17: 87–90
  • Faed E. Properties of acyl glucuronides: implications for studies of the pharmacokinetics and metabolism of acidic drugs. Drug Metabolism Reviews 1984; 15: 1213–1249
  • Grootveld M., Halliwell B. 2,3-Dihydroxygenzoic acid is a product of human aspirin metabolism. Biochemical Pharmacoloy 1988; 37: 271–280
  • Hutt A. J., Caldwell J., Smith R. L. The metabolism of aspirin in man: a population study. Xenobiotica 1986; 16: 239–249
  • Levy G. Pharmacokinetics of salicylate in man. Drug Metabolism Reviews 1979; 9: 3–19
  • Levy G., Tsuchiya T., Amsel P. Limited capacity for salicyl phenolic glucuronide formation and its effects on the kinetics of salicylate elimination in man. Clinical Pharmacology and Therapeutics 1972; 13: 258–268
  • Levy G., Vogel A., Amsel L. Capacity-limited salicylurate formation during prolonged administration of aspirin to healthy human subjects. Journal of Pharmaceutical Sciences 1969; 58: 503–504
  • National Poisons Information Service Monitoring Group. Analgesic poisoning; a multicentre, prospective survey. Human Toxicology 1981; 1: 7–23
  • Nelson E., Hanano M., Levy G. Comparative pharmacokinetics of salicylate elimination in man and rats. Journal of Pharmacology and Experimental Therapeutics 1966; 153: 159–166
  • Notarianni L. J., Ogunbona F. A., Oldham H. G., Patel D. K., Bennett P. N., Humphries S. J. Glycine conjugation of salicylic acid after aspirin overdose. British Journal of Clinical Pharmacology 1983; 15: 587P
  • Spenney J. G. Acetylsalicylic acid hydrolase of gastric mucosa. American Journal of Physiology 1978; 234: E606–E610
  • Trinder P. Rapid determination of salicylate in biological fluids. Biochemical Journal 1954; 57: 301–303
  • Wilson J. T., Howell R. L., Holladay M. W., Brillis G. M., Charstil J., Watson J. T., Taber D. F. Gentisuric acid: metabolic formation in animals and identification as a metabolite of aspirin in man. Clinical Pharmacology and Therapeutics 1978; 23: 635–643

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.