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Xenobiotica
the fate of foreign compounds in biological systems
Volume 21, 1991 - Issue 12
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Research Article

Malaria infection impairs glucuronidation and biliary excretion by the isolated perfused rat liver

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Pages 1571-1582 | Received 14 Mar 1991, Accepted 14 Jun 1991, Published online: 22 Sep 2008

References

  • Alvares A. P., Ueng T. H., Scheibel L. W., Hollingdale M. R. Impairment of hepatic cytochrome P-450-dependent monooxygenases by the malaria parasite Plasmodium bergei. Molecular Biochemical Parasitology 1984; 13: 277–282
  • Angus P. W., Mihaly G. W., Morgan D. J., Smallwood R. A. Oxygen dependence of salbutamol elimination by the isolated perfused rat liver. Biochemical Pharmacology 1989; 38: 1443–1449
  • Bargar E. M., Walle U. K., Bai S. A., Walle T. Quantitative metabolic fate of propranolol in the dog, rat, and hamster using radiotracer, high performance liquid chromatography, and gas chromatography-mass spectrometry techniques. Drug Metabolism and Disposition 1983; 11: 266–272
  • Bradley D. J., Newbold C. I., Warrell D. A. Malaria. Oxford Textbook of Medicine2nd edn. Oxford Medical Publications, Oxford 1986; vol. 1: 5.474–5.501
  • Ching M. S., Mihaly G. W., Angus P. W., Anderson J. D., Smallwood R. A. High performance liquid chromatographic analysis of Harmol and its conjugated metabolites in Biological Fluids. Journal of Chromatography 1986; 380: 190–195
  • Dutton G. J. Glucuronidation of Drugs and Other Compounds. CRC Press, Boca Raton, FL 1980
  • Emundianughe T. S., Brickle Q. D., Taylor M. G., Andrews B. Infection of Plasmodium berghei infection on benzoic acid metabolism in mice. Experientia 1985; 41: 1407–1409
  • Fulton J. D. Experiments on the utilization of sugars by malarial parasites (Plasmodium knowlesi). Annals of Tropical Medicine and Parasitology 1939; 33: 217–227
  • Hollingdale M. R. Malaria and the liver. Hepatology 1985; 5: 327–335
  • Hutchings M. J., Paull J. D., Morgan D. J. Determination of salbutamol in plasma by high-performance liquid chromatography with fluorescence detection. Journal of Chromatography 1983; 277: 423–426
  • Jones D. B., Mihaly G. W., Smallwood R. A., Webster L. K., Morgan D. J., Madsen N. P. Differential effects of hypoxia on the disposition of propranolol and sodium taurocholate by the isolated perfused rat liver. Hepatology 1984; 4: 461–466
  • Klaassen C. D., Watkins J. B. Mechanisms of bile formation, hepatic uptake and biliary excretion. Pharmacological Reviews 1984; 36: 2–62
  • Krijgsheld K. R., Koster H. J., Scholtens E., Mulder G. J. Cholestatic effect of harmol glucuronide in the rat. Prevention of harmol-induced cholestasis by increased formation of harmol sulfate. Journal of Pharmacology and Experimental Therapeutics 1982; 221: 731–734
  • Mansor S. M., Ward S. A., Edwards G., Hoaksey P. E., Breckenridge A. M. The effect of malaria infection on the disposition of quinine and quinidine in the rat isolated perfused liver preparation. Journal of Pharmacy and Pharmacology 1990; 42: 428–432
  • McCarthy J. S., Furner R. L., Van Dyke K., Stitzel R. E. Effects of malarial infection on host microsomal drug-metabolising enzymes. Biochemical Pharmacology 1970; 19: 1341–1349
  • McLean A. J., Morgan D. J. Clinical pharmacokinetics in patients with liver disease: 1991. Clinical Pharmacokinetics 1991; 21: 42–69
  • Mercado T. I., von Brand T. Glycogen studies on white rats infected with Plasmodium berghei. Experimental Parasitology 1954; 3: 259–266
  • Mihaly G. W., Morgan D. J., Smallwood R. A., Hardy K. J. The developing liver: The steady-state disposition of propranolol in pregnant sheep. Hepatology 1982; 2: 344–349
  • Mihaly G. W., Date N. M., Ireton H. J. C., Smallwood R. A. The effect of malaria infection on Primaquine elimination in the isolated perfused rat liver. Biochemical Pharmacology 1987a; 36: 225–228
  • Mihaly G. W., Date N. M., Veenendaal J. R., Newman K. T., Smallwood R. A. Decreased hepatic elimination of Pyrimethamine during malaria infection: Studies in the isolated perfused rat liver. Biochemical Pharmacology 1987b; 36: 2827–2829
  • Pang K. S., Rowland M. Hepatic clearance of drugs I. Theoretical considerations of a ‘well stirred’ model and a ‘parallel tube’ model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic system on hepatic drug clearance. Journal of Pharmacokinetics and Biopharmaceutics 1977; 5: 625–653
  • Pang K. S., Koster H., Halsema I. C. M., Scholtens E., Mulder G. J. Aberrent pharmacokinetics of Harmol in the perfused rat liver preparation: sulfate and glucuronide. Journal of Pharmacology and Experimental Therapeutics 1981; 219: 134–140
  • Patwari A., Aneja S., Berry A. M., Ghosh S. Hepatic dysfunction in childhood malaria. Archives of Diseases in Childhood 1979; 54: 139–141
  • Riley M. V., Deegan T. The effect of Plasmodium berghei on the mouse-liver mitochondria. Bicchemical Journal 1960; 76: 41–46
  • Rosen S., Roycroft D. W., Hano J. E., Barry K. G. The liver in malaria. Electron microscopic observations on a hepatic biopsy obtained 15 minutes post mortem. Archives of Pathology 1967; 83: 271–277
  • Rowland M., Tozer T. Clinical Pharmacokinetics. Lea & Febiger, New York 1989
  • Saxena N., Saxena A., Dutta G. P., Ghatak S., Pandey V. C. Effect of Plasmodium yoellii nigeriensis infection and chloroquine on the hepatic mixed function oxidase system of mice. Molecular Biochemical Parasitology 1987; 24: 283–187
  • Sharma O. P., Shukla R. P., Singh C., Sen A. B. Drug metabolising enzymes in mouse liver infected with Plasmodium berghei. Indian Journal of Parasitology 1978; 2: 29–30
  • Smallwood R. H., Morgan D. J., Mihaly G. W., Jones D. B., Smallwood R. A. Effect of plasma protein binding on elimination of taurocholate by isolated perfused rat liver: Comparison of venous equilibrium, undistributed and distributed sinusoidal and dispersion models. Journal of Pharmacokinetics and Biopharmaceutics 1988a; 16: 377–396
  • Smallwood R. H., Mihaly G. W., Smallwood R. A., Morgan D. J. Propranolol elimination as described by the venous equilibrium model using flow perubation in the isolated perfused rat liver. Journal of Pharmaceutical Science 1988b; 77: 330–333

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