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Xenobiotica
the fate of foreign compounds in biological systems
Volume 22, 1992 - Issue 4
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Original Article

The formation of metabolites of mephentermine by microsomal and cytosolic preparations of male Wistar rat livers

M.-A. Mori Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, 930–01, Japan
,
M. Kobayashi Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, 930–01, Japan
,
K. Sakai Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, 930–01, Japan
,
K. Nakafuku Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, 930–01, Japan
,
Y. Mori Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, 930–01, Japan
&
H. Kozuka Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, 930–01, Japan
Pages 451-457 | Received 07 Aug 1991, Accepted 07 Dec 1991, Published online: 27 Aug 2009

References

  • Beckett A. H., Belanger P. M. The identification of three new metabolic products of phentermine after liver microsomal incubation. Xenobiotica 1974; 4: 509–519
  • Beckett A. H., Belanger P. M. The identification and analysis of the metabolic products of mephentermine. Journal of Pharmacy and Pharmacology 1975; 27: 928–936
  • Beckett A. H., Belanger P. M. The microsomal N-oxidation of phentermine. Journal of Pharmacy and Pharmacology 1976; 28: 692–699
  • Beckett A. H., Belanger P. M. The in vitro metabolism of mephentermine. Biochemical Pharmacology 1977; 26: 1445–1462
  • Burstyn J. H., Iskandar M., Brady J. F., Fukuto J. M., Cho A. K. Comparative studies of N-hydroxylation and N-demethylation by microsomal cytochrome P-450. Chemical Research in Toxicology 1991; 4: 70–76
  • Cho A. K., Hodshon B. J., Lindeke B., Jonsson J. The p-hydroxylation of amphetamine and phentermine by rat liver microsomes. Xenobiotica 1975; 5: 531–538
  • Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 1951; 193: 265–275
  • Mori M., Matsuhashi T., Miyahara T., Shibata S., Tzima C., Kozuka H. Reduction of 2,4-dinitrotoluene by Wistar rat and liver microsomal and cytosol fractions. Toxicology and Applied Pharmacology 1984; 76: 105–112
  • Mori M., Uy-Yu N., Sakai K., Inoue M., Miyahara T., Kozuka H. Urinary and biliary metabolites of mephentermine in male Wistar rats. Xenobiotica 1989; 19: 287–299
  • Mori M., Uy-Yu N., Sakai K., Inoue M., Miyahara T., Kozuka H. Isolation of urinary p-hydroxylated metabolites of mephentermine and phentermine in male Wistar rats. Xenobiotica 1990; 20: 653–656
  • Mori M., Kobayashi M., Yumoto Y., Nakafuku K., Miyahara T., Kozuka H. Metabolism of mephentermine in male guinea pigs and male mice. Xenobiotica 1991; 21: 1301–1309
  • Sum C. Y., Cho A. K. The N-hydroxylation of phentermine by rat liver microsomes. Drug Metabolism and Disposition 1977; 5: 464–468
  • Yamada H., Baba T., Hirata Y., Oguri K., Yoshimura H. Studies on N-demethylation of methamphetamine by liver microsomes of guinea-pigs and rats: the role of flavin-containing mono-oxygenase and cytochrome P-450 systems. Xenobiotica 1984; 14: 861–866
  • Yamada H., Baba T., Oguri K., Yoshimura H. Enzymic reduction of N-hydroxyamphetamine: the role of electron transfer system containing cytochrome b5. Biochemical Pharmacology 1988; 37: 368–370
  • Yamamoto T., Takano R., Egashira T., Yamanaka Y. Metabolism of methamphetamine, amphetamine and p-hydroxymethamphetamine by rat-liver microsomal preparations in vitro. Xenobiotica 1984; 14: 867–875

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