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Xenobiotica
the fate of foreign compounds in biological systems
Volume 22, 1992 - Issue 6
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Research Article

Intestinal metabolism of mephentermine and its biliary metabolites in male Wistar rats

Masa-Aki Mori Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, 930-01, Japan
,
Mitsuru Kobayashi Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, 930-01, Japan
,
Hiromi Uemura Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, 930-01, Japan
,
Tatsuro Miyahara Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, 930-01, Japan
&
Hiroshi Kozuka Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, 930-01, Japan
Pages 701-708 | Received 05 Nov 1991, Accepted 20 Feb 1992, Published online: 22 Sep 2008

References

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  • Ingebrigtsen K., Fraslie A. Intestinal metabolism of DNOC and DNBP in the rat. Acta Pharmacologica et Toxicologica 1980; 46: 326–328
  • Mori M., Kudo Y., Nunozawa T., Miyahara T., Kozuka H. Intestinal metabolism of 2,4-dinitrotoluene in rats. Chemical and Pharmaceutical Bulletin 1985; 33: 327–332
  • Mori M., Uy-Yu N., Sakai K., Inoue M., Miyahara T., Kozuka H. Urinary and biliary metabolites of mephentermine in male Wistar rats. Xenobiotica 1989; 19: 287–299
  • Mori M., Kobayashi M., Yumoto Y., Nakafuku K., Miyahara T., Kozuka H. Metabolism of mephentermine in male guinea pigs and male mice. Xenobiotica 1991; 21: 1301–1309
  • Scheline R. P. Metabolism of foreign compounds by gastrointestinal microorganisms. Pharmacological Reviews 1973; 25: 451–523
  • Zachariah P. K., Juchau M. R. Role of gut fiora in the reduction of aromatic nitro groups. Drug Metabolism and Disposition 1974; 2: 74–78

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