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Xenobiotica
the fate of foreign compounds in biological systems
Volume 23, 1993 - Issue 4
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Research Article

Rat hepatocyte-mediated metabolism of the experimental anti-tumour agent N-[2-(dimethylamino)ethyl]acridine-4-carboxamide

B. Schlemper Department of Pharmacology and Clinical Pharmacology, University of Auckland School of Medicine, Private Bag, 92019, Auckland, New Zealand
,
D. J. Siegers Department of Pharmacology and Clinical Pharmacology, University of Auckland School of Medicine, Private Bag, 92019, Auckland, New Zealand
,
J. W. Paxton Department of Pharmacology and Clinical Pharmacology, University of Auckland School of Medicine, Private Bag, 92019, Auckland, New Zealand
&
I. G. C. Robertson Department of Pharmacology and Clinical Pharmacology, University of Auckland School of Medicine, Private Bag, 92019, Auckland, New Zealand
Pages 361-371 | Received 05 Dec 1991, Accepted 28 Jan 1993, Published online: 22 Sep 2008

References

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  • Paxton J. W., Young D., Evans S. M. H., Kestell P., Robertson I. G. C., Cornford E. M. Disposition and toxicity of the antitumour agentN-[2-dimethylamino)ethyl]acridine-4-carboxamide in the mouse. Cancer Chemotherapy and Pharmacology 1992; 29: 379–384
  • Robertson I. G. C., Palmer B. D., Officer M., Siegers D. J., Paxton J. W., Shaw G. J. Cytosol mediated metabolism of the experimental antitumour agent acridine carboxamide to the 9-acridone derivative. Biochemical Pharmacology 1991; 42: 1879–1884
  • Robertson I. G. C., Palmer B. D., Paxton J. W., Bland T. J. Metabolism of the experimental antitumour agent acridine carboxamide (AC) in the mouse. Drug Metabolism and Disposition 1993, (in press)
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  • Schwarze P. E., Petterson E. O., Seglen P. O. Characterization of hepatocytes from carcinogen-treated rats by two-parametric flow cytometry. Carcinogenesis 1986; 7: 171–173
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  • Yamada H., Baba T., Hirata Y., Oguri K., Yoshimura H. Studies onN-demethylation of methamphetamine by liver microsomes of guine? pigs and rats: the role of flavin-containing mono-oxygenase and cytochrome P-450 systems. Xenobiotica 1984; 14: 861–866

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