Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 24, 1994 - Issue 5
46
Views
3
CrossRef citations to date
0
Altmetric
Research Article

Identification of urinary metabolites of pyrilamine after oral administration to man

, , , , &
Pages 451-459 | Received 13 Jan 1994, Published online: 22 Sep 2008

References

  • Andrews A. W., Lijinsky W., Snyder S. W. Mutagenicity of amine drugs and their products of nitrosation. Mutation Research 1984; 135: 105–108
  • Budroe J. D., Shaddock J. G., Casciano D. A. A study of the potential genotoxicity of methapyrilene and related antihistamines using the hepatocyte/DNA repair assay. Mutation Research 1984; 135: 131–137
  • Chaudhuri N. K., Servanco O. A., Manniello M. J., Luders R. C., Chao D. K., Bartlett M. F. Metabolism of tripelennamine in man. Drug Metabolism and Disposition 1976; 4: 372–378
  • Dieterle W., Faigle J. W., Mory H., Richter W. J., Theobald W. Biotransformation and pharmacokinetics of sulfinpyrazone (Auturan) in man. European Journal of Clinical Pharmacology 1975; 9: 135–145
  • Douglas W. W. Histamine and 5-hydroxytryptamine (serotonin) and their antagonists. The Pharmacological Basis of Therapeutics, A. G. Gilman, L. S. Goodman, A. Oilman. Macmillan, New York 1985; 605–638
  • Haley T. J. Physical and biological properties of pyrilamine. Journal of Pharmaceutical Sciences 1983; 72: 3–12
  • Hansen E. B., Jr., Cerniglia C. E., Korfmacher W. A., Miller D. W., Helflich R. H. Microbial transformation of the antihistamine pyrilamine maleate. Formation of potential mammalian metabolites. Drug Metabolism and Disposition 1987; 15: 97–106
  • Kammerer R. C., Schmitz D. A., Lampe M. A., Kloc K. The in vivo metabolism of methopyrilene, a hepato carcinogen, in the rat. Xenobiotica 1988; 18: 869–881
  • Kelly D. W., Slikker W., Jr. The metabolism and elimination of pyrilamine maleate in the rat. Drug Metabolism and Disposition 1987; 15: 460–465
  • Korfmacher W. A., Freeman J. P., Geteck T. A., Bloom J., Holder C. L. Analysis of rat urine for metabolites of pyrilamine in high performance liquid chromatography-thermospray mass spectrometry and tandem mass spectrometry. Biomedicine and Environmental Mass Spectrometry 1989; 19: 191–201
  • Korfmacher W. A., Holder C. L., Cerniglia C. E., Miller D. W., Hansen E. B., Lambert K. L., Gosnell A. B., Slikker W., Jr., Rushing L. G., Thompson H. C., Jr. Desorption chemical ionization mass spectiometry of nine antihistamines and some of their metabolites. Spectrosc. Int. J. 1985; 4: 181–191
  • Korfmacher W. A., Holder C. L., Gosnell A. B., Thompson H. C., Jr. Identification of pyrilamine metabolites by ammonia chemical ionization mass spectrometry. Journal of the Annals of Toxicology 1986; 10: 142–146
  • McQueen C. A., Williams G. M. Characterization of DNA repair elicited by carcinogens and drugs in the hepatocyte primary culture/DNA repair test. Journal of Toxicology and Environmental Health 1981; 8: 463–467
  • Oberly T. J., Brewsy B. J., Probst G. S. An evaluation of the L51 7bTK mouse lymphoma forward mutations assay using 42 chemicals. Mutation Research 1984; 125: 291–303
  • Probst G. S., Neal S. B. The induction of unscheduled DNA synthesis by antihistamines in primary hepatocyte cultures. Cancer Letters 1980; 10: 67–73
  • Richter W. J., Alt K. O., Dieterle W., Faigle J. W., Kriemler H. P., Mory H., Winkler T. C-glucuronides, a novel type of drug metabolite. Helvetica Chimica Acta 1975; 58: 2512–2517
  • Thompson H. C., Jr., Holder C. L., Siitonen P. H., Rowland K. L., Gosnell A. B., Cmarik J. L. Metabolism of pyrilamine maleate in Fisher 344 rats, part 1. Activity excretion profiles. Journal of the Annals of Toxicology 1987; 11: 252–256
  • Yeh S. Y. N-debenzylation of pyrilamine and tripelennamine in the rat: a new metabolic pathway. Drug Metabolism and Disposition 1987; 15: 466–472

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.