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Xenobiotica
the fate of foreign compounds in biological systems
Volume 24, 1994 - Issue 10
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Original Article

D-Penicillamine metabolism in neurodegenerative diseases: An in vivo/in vitro sulphydryl methylation study

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Pages 1013-1020 | Received 19 Apr 1994, Published online: 27 Aug 2009

References

  • Bradford M. M. A rapid sensitive method for the quantitation of microgram quantities of protein utilizing the principal of protein-dye binding. Analytical Biochemistry 1976; 72: 248–254
  • Bremer J., Greenberg D. M. Enzymic methylation of foreign sulphydryl compounds. Biochimica et Biophysica Acta 1961; 46: 217–224
  • Drummer O. H., Jarrot B., Louis W. H. Demonstration of a S-methyl metabolite of captopril in patients undergoing captopril therapy. Clinical and Experimental Pharmacology and Physiology 1982; 7: 81–96, Suppl.
  • Heafield M. T. E., Fearn S., Steventon G. B., Sturman S. G., Waring R. H., Williams A. C. Plasma cysteine and sulphate levels in patients with Motor Neurone, Parkinson's and Alzheimer's Disease. Neuroscience Letters 1990; 110: 216–220
  • Hirschberger L. L., Dela Rosa J., Stipanuck M. H. Determination of cysteine sulfinate, hypotaurine and taurine in physiological samples by reversed-phase high-performance liquid chromatography. Journal of Chromatography 1985; 343: 303–313
  • Keith R. A., Kerremans A. L., Otterness D. M., Weinshilboum R. M. S-methylation of D- and L-penicillamine by human erythrocyte membrane thiol methyltransferase. Drug Metabolism and Disposition 1985; 83: 669–676
  • Mircheva T., Vidailhet M., Marconi R., Bonner A. M., Beaune P., Agid Y. Selective decrease in S-methylation in Parkinson's Disease. Neurology 1993; 43(Suppl. 2)A154–155
  • Mitchell S. C., Waring R. H. The deficiency of sulphoxidation of S-carboxymethyl-L-cysteine. Pharmacology and Therapeutics 1989; 43: 237–249
  • Mopper K., Delmas D. Trace determination of biological thiols by liquid chromatography and precolumn fluorometric labeling with o-phthaldehyde. Analytical Chemistry 1984; 56: 2257–2560
  • Oxley J. W., Zorumski C., Price M. T., Labruyere J. L-Crysteine, a bicarbonate-sensitive endogenous excitotoxin. Science 1990; 248: 596–599
  • Perrett O., Sneddon W., Stephens A. D. Studies on D-penicillamine metabolism in cystinuria and rheumatoid arthritis: isolation of S-methyl-D-penicillamine. Biochemical Pharmacology 1976; 25: 259–264
  • Reed D. J., Babson J. R., Beatty P. W., Brodie A. E., Ellis W. W., Potter D. W. High-performance liquid chromatography analysis of nanomole levels of glutathione, glutathione disulphide and related thiols and disulphides. Analytical Biochemistry 1980; 106: 55–62
  • Reicks M., Hathcock J. N. Effects of methionine and other sulfur compounds on drug conjugations. Pharmacology and Therapeutics 1988; 37: 67–79
  • Shaw I. C., Boult C. H., McLean A. E. M. Analysis of D-penicillamine by high-performance liquid chromatography with glassy carbon electrochemical detection. Journal of Chromatography 1983; 275: 206–210
  • Sherry J. H., O'donell J. P., Colby H. D. Separation of spironolactone and its biological active sulfur-containing metabolites by high-performance liquid chromatography. Journal of Chromatography 1986; 374: 183–190
  • Steventon G., Adams D., Pall H. S., Waring R. H., Williams A. C. Xenobiotic metabolism in Motor Neurone Disease. Lancet 1988; ii: 644–647
  • Steventon G. B., Heafield M. T. E., Waring R. H., Williams A. C. Xenobiotic metabolism in Parkinson's disease. Neurology 1989; 39: 893–887
  • Steventon G. B., Heafield M. T. E., Waring R. H., Williams A. C., Sturman S., Green M. Metabolism of low-dose paracetamol in patients with chronic neurological disease. Xenobiotica 1990; 20: 117–122
  • Waring R. H., Mitchell S. C. The metabolism of 35S-D-penicillamine in man. Xenobiotica 1988; 18: 235–244
  • Waring R. H., Steventon G. B., Heafield M. T. E., Sturman S. G., Williams A. C., Smith M. C. G. S-methylation in Motor Neurone Disease and Parkinson's disease. Lancet 1989; ii: 356–357
  • Weisiger R. A., Jakoby W. B. Thiol S-methyltransferase from rat liver. Archives of Biochemistry and Biophysics 1979; 196: 631–637

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