Protective effects of Osbeckia octandra against paracetamol-induced liver injury

References

• Albano E., Rundgren M., Harvison P. J., Nelson S. D., Moldeus P. Mechanisms of N-acetyl-p-benzoquinoneimine cytotoxicity. Molecular Pharmacology 1985; 28: 306–311
   PubMed Web of Science ®Google Scholar
• Attygalla J. Sinhalese Materia Medica, 2nd edn. Gunasena M.D. and Co., Sri Lanka 1972; 91
   Google Scholar
• Burcham P. C., Harman A. W. Acetaminophen toxicity results in site-specific mitochondrial damage in isolated mouse hepatocytes. Journal of Biological Chemistry 1991; 266: 5049–5054
   PubMed Web of Science ®Google Scholar
• Davis D. C., Potter W. Z., Jollow D. J., Mitchell J. R. Species differences in hepatic glutathione depletion, covalent binding and hepatic necrosis after acetaminophen. Life Sciences 1974; 14: 2099–2109
   PubMed Web of Science ®Google Scholar
• Deakin C. D., Gove C. D., Fagan E. A., Tredger J. M., Williams R. Delayed calcium channel blockade with diltiazen reduces paracetamol hepatotoxicity in mice. Human and Experimental Toxicology 1991; 10: 119–123
   Google Scholar
• Gazzard B. G., Hughes R. D., Portmann B., Dordoni B., Williams R. Protection of rats against the hepatotoxic effects of paracetamol. British Journal of Experimental Pathology 1974; 55: 601–605
   Google Scholar
• Gove C. D., Hughes R. D., Williams R. Rapid inhibition of DNA synthesis in hepatocytes from regenerating rat livers by serum from patients with fulminant hepatic failture. British Journal of Experimental Pathology 1982; 63: 547–553
   PubMedGoogle Scholar
• Hikino H., Tohkin M., Kiso Y., Namiki T., Nishimura S., Takeyama K. Antihepato-toxic actions of Allium sativum bulbs. Planta Medica 1986; 52: 163–168
   Google Scholar
• Hinson J. A. Biochemical toxicology of acetaminophen. Reviews in Biochemical Toxicology, E. Hodgson, J. R. Bend, R. M. Philpot. Elsevier, Amsterdam 1980; vol. 2: 103–129
   Google Scholar
• Hissin P. J., Hilf R. A fluorimetric method for the determination of oxidized and reduced glutathione in tissues. Analytical Biochemistry 1976; 74: 214–226
   PubMed Web of Science ®Google Scholar
• Hoffmann K. J., Streeter A. J., Axworthy D. B., Baillie T. A. Identification of the major covalent adduct formed in vitro and in vivo between acetaminophen and mouse liver proteins. Molecular Pharmacology 1985; 27: 566–573
   PubMed Web of Science ®Google Scholar
• Jayatilaka K. A. P. W., Thabrew M. I., Pathirana C., De Silva D. G. H., Perera D. J. B. An evaluation of the potency of Osbeckia octandra and Melothria maderaspantana as antihepatotoxic agents. Planta Medica 1989; 55: 137–139
   Google Scholar
• Jayaweera D. M. A. Medicinal Plants Used in Ceylon. National Science Council of Sri-Lanka, Colombo 1952; vol. IV: 47
   Google Scholar
• Kiso Y., Tohkin M., Hikino H., Hattori M., Sakamoto T., Namba T. Mechanism of antihepatotoxic activity of Glycerrhizin I. Effect of free radical generation and lipid peroxidation. Planta Medica 1984; 50: 298–302
   PubMed Web of Science ®Google Scholar
• Landon E. J., Naukam R. J., Ramasastry B. V. Effect of of calcium channel blocking agents on calcium channel blocking agents on calcium and centrilobular necrosis in the liver of rats treated with hepatotoxic agents. Biochemical Pharmacology 1986; 35: 697–705
   PubMed Web of Science ®Google Scholar
• Li Q. J., Jos G. M., Bessems J. N. M., Commandeur B. A., Nico P. E. V. Mechanisms of protection of ebselen against paracetamol-induced toxicity in rat hepatocytes. Biochemical Pharmacology 1994; 48: 1631–1640
   PubMedGoogle Scholar
• Miners J. O., Drew R., Birkett D. J. Mechanism of action of paracetamol protective agents in mice. Biochemical Pharmacology 1984; 33: 2995–3000
   PubMed Web of Science ®Google Scholar
• Moore M., Thor H., Moore G., Nelson S., Moldeus P., Orrhenius S. The toxicity of acetaminophen and N-acetyl-p-benzoquinonimine in isolated hepatocytes is associated with thiol depletion and increased cytosolic Ca2+. Journal of Biological Chemistry 1985; 260: 13035–13040
   PubMed Web of Science ®Google Scholar
• Nicotera P., Rundgren M., Porubek D. J., Cotgreave I., Moldeus P., Orrenius S., Nelson S. D. On the role of Ca2+ in the toxicity of alkylating and oxidising quinone in isolated hepactocytes. Chemical Research in Toxicology 1989; 2: 46–50
   PubMed Web of Science ®Google Scholar
• Prescott L. F., Illingworth R. N., Critchley J. A., Stewart M. J., Adam R. D., Proudfoot A. T. Intravenous N-acetyl cysteine: the treatment of choice for paracetamol poisoning. British Medical Journal 1979; 2: 1097–1100
   PubMed Web of Science ®Google Scholar
• Ruddick J. A. Toxicology, metabolism and biochemistry of 1,2-propanediol. Toxicology and Applied Pharmacology 1972; 2: 102–111
   Google Scholar
• Schiller C. D., Kainz A., Mynett K., Gesher A. Assessment of viability of hepatocytes in suspension using the MTT assay. Toxicology In Vitro 1992; 6: 575–578
   PubMedGoogle Scholar
• Smith C. V., Mitchell J. R. Acetaminophen hepatotoxicity in vivo is not accompanied by oxidant stress. Biochemical and Biophysical Research Communications 1985; 27: 329–336
   Google Scholar
• Thabrew M. I., Gove C. D., Hughes R. D., Williams R. Hepatoprotective effects of the plant Osbeckia octandra. Gut 1992; 33(Supple.)S26
   Google Scholar
• Thabrew M. I., Joice P. D. T. M., Rajatissa W. C. A comparative study of the efficacy of Osbeckia octandra and Pavetta indica in the treatment of liver dysfunction. Journal of Ethnopharmacology 1987; 23: 305–312
   Google Scholar
• Tredger J. M., Smith H. M., Read R. B., Portmann B., Williams R. Effects of ethanol ingestion to the hepatotoxicity and metabolism of paracetamol in mice. Toxicology 1985; 36: 341–352
   PubMed Web of Science ®Google Scholar
• Valenzuela A., Guerra R., Videla L. A. Antioxidant properties of the flavanoids sylibin and + -cyanidanol-3: comparison with butylated hydroxyanisole and butylated hydroxytoluene. Planta Medica 1986; 52: 438–440
   Web of Science ®Google Scholar
• Van De Straat R., De Vries J., Debets A. J. J., Vermeulen N. P. E. The mechanism of prevention of paracetamol-induced hepatotoxicity by 3,5-dialkyl substitution. The roles of glutathione depletion and oxidative stress. Biochemical Pharmacology 1987; 36: 2065–2070
   PubMed Web of Science ®Google Scholar
• Wendel A., Feuerstein S., Konz K. H. Acute paracetamol intoxication of starved mice leads to lipid peroxidation in vivo. Biochemical Pharmacology 1979; 28: 2051–2055
   PubMed Web of Science ®Google Scholar
• Wendel A., Feuerstein S. Drug-induced lipid peroxidation in mice. 1. Modulation by monooxygenase activity, glutathione and selenium status. Biochemical Pharmacology 1981; 30: 2513–2520
   PubMed Web of Science ®Google Scholar
• Wendel A., Jaeschka H., Gloger M. Drug-induced lipid peroxidation in mice. II. Protection against paracetamol-induced liver necrosis by intravenous liposomally entrapped glutathione. Biochemical Pharmacology 1982; 31: 3601–3605
   PubMed Web of Science ®Google Scholar