Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 25, 1995 - Issue 8
47
Views
25
CrossRef citations to date
0
Altmetric
Research Article

Metabolism of pimobendan in long-term human hepatocyte culture: in vivo-in vitro comparison

, , , &
Pages 811-823 | Received 20 Dec 1994, Published online: 22 Sep 2008

References

  • Akrawi M., Rogiers V., Vandenberghe Y., Palmer C. N., Vercruysse A., Shephard E. A., Phillips I. R. Maintenance and induction in co-cultured rat hepatocytes of components of the cytochrome P450-mediated mono-oxygenase. Biochemical Pharmacology 1993; 45: 1583–1591
  • Bader A., Christians U., Böker K., Sattler M., Sewing K. F., Pichlmayr R. In vitro imitation of the in vivo three-dimensional microenvironment enables primary hepatocytes to maintain stable metabolic functions. Cell Transplantation 1992; 1: 162
  • Bader A., Zech K., Crome O., Christians U., Ringe N., Pichlmayr R., Sewing K. F. Use of organotypical cultures of primary hepatocytes to analyse drug biotransformation in man and animals. Xenobiotica 1994; 24: 623–633
  • Begue J. M., Guguen-Guillouzo G. C., Pasdelout N., Guillouzo A. Prolonged maintenance of active cytochrome P-450 in adult rat hepatocytes co-cultured with another liver cell type. Hepatology 1984; 4: 839–842
  • Berthou F., Ratanasavanh D., Alix D., Carlhant D., Riche C., Guillouzo A. Caffeine and theophylline metabolism in newborn and adult human hepatocytes; comparison with adult rat hepatocytes. Biochemical Pharmacology 1988; 37: 3691–3700
  • Bissell D. M., Arenson D. M., Maher J. J., Roll F. J. Support of cultured hepatocytes by a laminin-rich gel. Evidence for a functionally significant subendothelial matrix in normal rat liver. Journal of Clinical Investigation 1987; 79: 801–512
  • Clayton D. F., Darnell J. E. Changes in liver-specific compared to common gene transcription during transcription during primary culture of mouse hepatocytes. Molecular and Cellular Biology 1983; 3: 1552–1561
  • Dogterom P. Development of a simple incubation system for metabolism studies with precision-cut liver slices. Drug Metabolism and Disposition 1993; 21: 699–704
  • Dunn J. C., Tompkins R. G., Yarmush M. L. Hepatocytes in collagen sandwich: evidence for transcriptional and translational regulation. Journal of Cell Biology 1992; 116: 1043–1053
  • Dunn J. C., Yarmush M. L., Koebe H. G., Tompkins R. G. Hepatocyte function and extracellular matrix geometry: long-term culture in a sandwich configuration. FASEB Journal 1989; 3: 174–177
  • Fabre G., Rahmani R., Placidi M., Combalbert J., Covo J., Cano J. P., Coulange C., Ducros M., Rampal M. Characterization of midazolam metabolism using human hepatic microsomal fractions and hepatocytes in suspension obtained by perfusing whole human livers. Biochemical Pharmacology 1988; 37: 4389–4397
  • Gómez-Léchon M. J., López P., Donato T., Montoya A., Larrauri A., Giménez P., Trullenque R., Fabra R., Castell J. V. Culture of human hepatocytes from small surgical liver biopsies. Biochemical characterization and comparison with in vivo. In vitro Cellular and Developmental Biology 1990; 26: 67–74
  • Gugen-Guillouzo C., Campion J. P., Brissot P., Glaise D., Launois B., Bourel M., Guillouzo A. High yield preparation of isolated human adult hepatocytes by enzymatic perfusion of the liver. Cell Biology International Reports 1982; 6: 625–628
  • Gugen-Guillouzo C., Clement B., Baffet G., Beaumont C., Morel-Chany C. E., Glaise D., Guillouzo A. Maintenance and reversibility of active albumin secretion by adult rat hepatocytes co-cultured with another liver epithelial cell type. Experimental Cell Research 1983; 143: 47–54
  • Guillouzo A., Beaune P., Gascoin M. N., Begue J. M., Campion J. P., Guengerich F. P., Gugen-Guillouzo C. Maintenance of cytochrome P-450 in cultured adult human hepatocytes. Biochemical Pharmacology 1985; 34: 2991–2995
  • Guillouzo A., Begue J. M., Maurer G., Koch P. Identification of metabolic pathways of pindolol and fluperlapine in adult human hepatocyte cultures. Xenobiotica 1988; 18: 131–139
  • Guillouzo A., Morel F., Fardel O., Meunier B. Use of human hepatocyte cultures for drug metabolism studies. Toxicology 1993; 82: 209–219
  • Guzelian P. S., Li D., Schuetz E. G., Thomas P., Levin W., Mode A., Gustafson J. A. Sex change in cytochrome P-450 phenotype by growth hormone treatment of adult rat hepatocytes maintained in a culture system on matrigel. Proceedings of the National Academy of Sciences, USA 1988; 85: 9783–9787
  • Hagemeijer F. Calcium sensitization with pimobendan: pharmacology, haemodynamic improvement, and sudden death in patients with chronic congestive heart failure. European Heart Journal 1993; 14: 551–566
  • Isom H. C., Secott T., Georgoff I., Woodworth C., Mummaw J. Maintenance of differentiated rat hepatocytes in primary culture. Proceedings of the National Academy of Sciences, USA 1985; 82: 3252–3256
  • Koebe H. G., Pahernik S., Eyer P., Schildberg F. W. Collagen gel immobilization: a useful cell culture technique for long-term metabolic studies on human hepatocytes. Xenobiotica 1994; 24: 95–107
  • Le Bigot J. F., Begue J. M., Kiechel J. R., Ghuillouzo A. Species differences in metabolism of ketotifen in rat, rabbit and man: demonstration of similar pathways in in vivo and in cultured hepatocytes. Life Sciences 1987; 40: 883–890
  • Lindsay C. K., Chenery R. J., Hawksworth G. M. Primary culture of rat hepatocytes in the presence of dimethylsulphoxide. A system to investigate the regulation of cytochrome P450 IA. Biochemical Pharmacology 1991; 42(Suppl.)S17–25
  • Miyazaki M., Handa Y., Oda M., Yabe T., Miyano K., Sato J. Long-term survival of functional hepatocytes from adult rat in the presence of phenobarbital in primary culture. Experimental Cell Research 1985; 159: 176–190
  • Oldham H. G., Standring P., Norman S. J., Blake T. J., Beattie I., Cox P. J., Chenery R. J. Metabolism of temelastine (SK&F 93944) in hepatocytes from rat, dog, cynomolgus monkey and man. Drug Metabolism and Disposition 1990; 18: 146–152
  • Padgham C. R., Boyle C. C., Wang X. J., Raleigh S. M., Wright M. C., Paine A. J. Alteration of transcription factor mRNAs during the isolation and culture of rat hepatocytes suggests the activation of a proliferative mode underlies their de-differentiation. Biochemical and Biophysical Research Communications 1993; 197: 599–605
  • Padgham C. R., Paine A. J., Phillips I. R., Shephard E. A. Maintenance of total cytochrome P-450 content in rat hepatocyte culture and the abundance of CYP1A2 and CYP2B1/2 mRNAs. Biochemical Journal 1992; 285: 929–932
  • Padgham C. R., Paine A. J., Phillips I. R., Shephard E. A. Maintenance of cytochrome P-450IA2, IIB1 and IIB2 mRNAs by metyrapone in rat hepatocyte culture. Biochemical Society Transactions 1990; 18: 1203, 1990
  • Paine A. J. The maintenance of cytochrome P-450 in rat hepatocyte culture: some applications of liver cell cultures to the study of drug metabolism, toxocity and the induction of the P-450 system. Chemico-Biological Interactions 1990; 74: 1–31
  • Reese J. A., Byard J. L. Isolation and culture of adult hepatocytes from liver biopsies. In Vitro Cellular and Developmental Biology 1981; 17: 935–940
  • Richard B., Fabre G., De Souza G., Fabre I., Rahmani R., Cano J. P. Interspecies variability in mitoxantrone metabolism using primary cultures of hepatocytes isolated from rat, rabbit and humans. Biochemical Pharmacology 1991; 41: 255–262
  • Rogiers V., Vandenberghe Y., Callaerts A., Verleye G., Cornet M., Mertens K., Sonck W., Vercruysse A. Phase I and II xenobiotic biotransformation in cultures and co-cultures of adult rat hepatocytes. Biochemical Pharmacology 1990; 40: 1701–1706
  • Ryan C. M., Carter E. A., Jenkins R. L., Sterling L. M., Yarmush M. L., Malt R. A., Tompkins R. G. Isolation and long-term culture of human hepatocytes. Surgerry 1993; 113: 48–54
  • Sandker G. W., Vos R. M. E., Delbressine L. P. C., Slooff M. J. H., Meijer D. K. F., Groothius G. M. M. Metabolism of three pharmacologically active drugs in isolated human and rat hepatocytes: analysis of interspecies variability and comparison with metabolism in vivo. Xenobiotica 1994; 24: 143–155
  • Schmid J., Roth W. HPLC-procedures for drug metabolism studies: the potential of column switching. Drug Metabolism From Molecule to Man, J. Benford, J. W. Bridges, G. G. Gibson. Taylor & Francis, London 1987; 213–216
  • Seddon T., Michelle I., Chenery R. J. Comparative drug metabolism of diazepam in hepatocytes isolated from man, rat, monkey and dog. Biochemical Pharmacology 1989; 38: 1657–1665
  • Strom S. C., Jirtle R. L., Jones R. S., Novicki D. L., Rosenberg M. R., Novotny A., Irons G., McLain J. R., Michalopoulos G. Isolation, culture, and transplantation of human hepatocytes. Journal of the National Cancer Institute 1982; 68: 771–778
  • Tee L. B., Seddon T., Boobis A. R., Davies D. S. Drug metabolising activity of freshly isolated human hepatocytes. British Journal of Clinical Pharmacology 1985; 19: 279–294
  • Vind C., Dich J., Grunnet N. The content and activity of cytochrome P-450 in long-term culture of hepatocytes from male and female rats. Biochemical Pharmacology 1988; 27: 1371–1375
  • Yarmush M. L., Toner M., Dunn J. C., Rotem A., Hubel A., Tompkins R. G. Hepatic tissue engineering. Development of critical technologies. Annals of the New York Academy of Sciences 1992; 665: 238–252

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.