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Xenobiotica
the fate of foreign compounds in biological systems
Volume 26, 1996 - Issue 1
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Research Article

Dose-dependent kinetics and metabolism of 1,2-dichlorobenzene in rat: effect of pretreatment with phenobarbital

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Pages 89-105 | Published online: 17 Nov 2010

References

  • ALLIS, J. W., SIMMONS, J. E., HOUSE, D. E., ROBINSON, B. L., and BERMAN, E., 1992, The differential hepatotoxicity and cytochrome P450 responses of Fischer-344 rats to the three isomers of dichlorobenzene. Biochemical Toxicology, 7, 257–264,
  • AZOUZ, W. M., PARKE, D. V., and WILLIAMS, R. T., 1955, The metabolism of halogenobenzenes: ortho-and para-dichlorobenzenes. Biochemical Journal, 59, 410–415.
  • BAKKE, J. E., fluwE, J. K., MuLFonn, D. J., and BERGMAN, A., 1992, Metabolism of 1,2,4-trichloro-benzene in rats: examination of thiol formation. Xenobiotica, 22, 199–210.
  • BRODIE, B. B., REID, W. D., Ctto, A. K., SIPES, G., KRISHNA, G., and GILLETTE, J. R., 1971, Possible mechanism of liver necrosis caused by aromatic organic compounds. Proceedings of the National Academy of Sciences, USA, 68, 160–164.
  • BRONDEAU, M. T., BAN, M., BONNET, P., GT7ENIER, J. P., and DE CEAURRIZ, J., 1989, Acetone compared to other ketones in modifying the hepatotoxicity of inhaled 1,2-dichlorobenzene in rats and mice. Toxicology Letters, 49, 69–78.
  • CAMERON, G. R., THOMAS, J. C., ASHMORE, S. A., BUCHAN, J. L., WARREN, E. H., and MCKF.NNY HUGHES, A. W., 1937, The toxicity of certain chlorine derivatives of benzene, with special reference to o-dichlorobenzene. journal of Pathology and Bacteriology, 44, 281–296.
  • DEN BESTEN, C., ELLENBROEK, M., VAN DER REE, M. A. E., RIETJENS, I. M. C. M., and VAN BLADEREN, P. J., 1992, The involvement of primary and secondary metabolism in the covalent binding of 1,2-and 1,4-dichlorobenzenes. Chemical and Biological Interactions, 84, 259–275.
  • DEN BESTEN, C., VET, J. J. R. M., BESSELINK, H. T., KIEL, G. S., VAN BERKEI., B. J. M., BEEMS, R., and VAN BLADEREN, P. J., 1991, The liver, kidney, and thyroid toxicity of chlorinated benzenes. Toxicology and Applied Pharmacology, 111, 69–81.
  • D'SOUZA, R. W., FRANCIS, W. R., and .ANnFalsEN, M. E., 1988, Physiological model for tissue gIutathione depletion and increased resynthesis after ethylene dichloride exposure. Journal of Pharmacology and Experimental Therapeutics, 245, 563–568.
  • FISHER, R., SMITH, P. F., SIPES, I. G., GANDOLFI, A. J., KRUMDIECK, C. L., and BRENDEL, K., 1990, Toxicity of chlorobenzenes in cultured rat liver slices. In Vitro Toxicology 3, 181–194,
  • GUNAWARDHANA, L., MoBLEY, S. A., and SIPES, I. G., 1993, Modulation of 1,2-dichlorobenzene hepatotoxicity in the Fischer-344 rat by a scavenger of superoxide anions and an inhibitor of Kupffer cells. Toxicology and Applied Pharmacology, 119, 205–213.
  • HOLLINGSWORTH, R. L., ROWE, V. K., OYEN, F., TORKELSON, T. R., and ADAMS, E. M., 1958, Toxicity of o-dichlorobenzene. Archives of Industrial Health, 17, 180–187.
  • JOLLOW, D. J., MITCHELL, J. R., ZAMPAGLIONE, N., and GILLETTE, J. R., 1974, Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite. Pharmacology, 11, 151–169.
  • LAU, S. S., ABRAMS, G. D., and ZANNONI, V. G„ 1980, Metabolic activation and detoxification of bromobenzene leading to cytotoxicity. Journal of Pharmacology and Experimental Therapeutics, 214, 703–708.
  • LAU, S. S., and ZANNONI, V. G., 1981, Bromobenzene metabolism in the rabbit. Specific forms of cytochrome P-450 involved in 2,3- and 3,4-epoxidation. Molecular Pharmacology, 20, 234–235.
  • NARASIMHAN, N., WELLER, P. E., BUBEN, J. A., WILEY, R. A., and HANZLIK, R. P., 1988, Microsomal metabolism and covalent binding of [5H/14C1-bromobenzene. Evidence for quinones as reactive metabolites. Xenobiotica, 18, 491–499.
  • OLIVER, B. G., and NICOL, K. D., 1982, Chlorobenzenes in sediments, water, and selected fish from lakes Superior, Huron, Erie, and Ontario. Environmental Sciences and Technology, 16, 532–536.
  • REID, W. D., 1972, Relationship between tissue necrosis and covalent binding of toxic metabolites of halogenated aromatic hydrocarbons. Pharmacology and the Future of Man, 2, 62–74,
  • REID, W. D., and KRISHNA, G., 1973, Centrolobular hepatic necrosis related to covalent binding of metabolites of halogenated aromatic hydrocarbons. Experimental Molecular Pathology, 18, 80–99.
  • REID, W. D., KRISHNA, G., GILLETTE, J. R., and BRODIE, B. B., 1973, Biochemical mechanism of hepatic necrosis induced by aromatic hydrocarbons. Pharmacology, 10, 193–214.
  • ROBINSON, M., BERCZ, J. P., RINGHAND, H. P., CONDIE, L. W., and PARNELL, M. J., 1991, Ten- and ninety-day toxicity studies of 1,2-dichlorobenzene administered by oral gavage to Sprague-Dawley rats. Drug and Chemical Toxicology, 14, 83–112.
  • SLAUGHTER, D. E., and HANZLIK, R. P., 1991, Identification of epoxide- and quinone-derived bromobenzene adducts to protein sulfur nucleophiles. Chemical Research in Toxicology, 4, 349–359.
  • STINE, E. R., GUNAWARDHAIVA, L., and SIPES, I. G., 1991, The acute hepatotoxicity of the isomers of dichlorobenzene in Fischer-344 and Sprague-Dawley rats: isomer-specific and strain-specific differential toxicity. Toxicology and Applied Pharmacology, 19, 472–481.
  • VALENTOVIC, M. A., BALL, J. G., ANESTIS, D., and MADAN, E., 1993, Modification of P450 activity and its effect on 1,2-dichlorobenzene toxicity in Fischer-344 rats. Toxicology, 79, 169–180.
  • ZHENG, J., and HANZLIK, R. P., 1992, Dihydroxylated mercapturic acid metabolites of bromobenzene. Chemical Research in Toxicology, 5, 561–567.
  • ZOETEMAN, B. C. J., HARMSEN, K., LINDERS, J. B. H. J., MORFtA, C. F. H., and SLOOFF, W., 1980, Persistent organic pollutants in river water and ground water of the Netherlands. Chemosphere, 9, 231–249.

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