Time to Abandon the Self-Medication Hypothesis in Patients with Psychiatric Disorders

REFERENCES

• Khantzian EJ. The self-medication hypothesis of addictive disorders: Focus on heroin and cocaine dependence. Am J Psychiatry 1985; 142(11):1259–1264.
   PubMed Web of Science ®Google Scholar
• Cocchi R, Tornati A. Psychic dependence? A different formulation of the problem with a view to the reorientation of therapy for chronic drug addiction. Acta Psych 1977; 56(5):337–346.
   Google Scholar
• Rado S. The psychoanalysis of pharmacothymia. Psychoanal Q 1933; 2:1–23.
   Google Scholar
• Google Scholar. Available at http://scholar.google.com/. Accessed on September 23, 2011.
   Google Scholar
• Khantzian EJ. The self-medication hypothesis of substance use disorders: A reconsideration and recent applications. Harvard Rev Psychiatry 1997; 4(5):287–289.
   PubMed Web of Science ®Google Scholar
• Khantzian EJ. Treating Addiction as a Human Process. Northvale, NJ: Library of Substance Abuse and Addiction Treatment, Jason Aronson, 1999; 687.
   Google Scholar
• Khantzian EJ, Albanese MJ. Understanding Addiction as Self-Medication: Finding Hope Behind the Pain. Lanham, MD: Rowman & Littlefield Publishers, Inc, 2008.
   Google Scholar
• Mueser KT, Drake RE, Wallach MA. Dual diagnosis: A review of etiologic theories. Addict Behav 1998; 23(6):717–734.
   PubMed Web of Science ®Google Scholar
• American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (4th ed., Text Revision). Washington, DC: American Psychiatric Association, 2000.
   Google Scholar
• Szasz T. The myth of mental illness. Am Psychol 1960; 15:113–118.
   Web of Science ®Google Scholar
• Shaffer HJ. Conceptual crises and the addictions: A philosophy of science perspective. J Subst Abuse. 1986; 3:285–296.
   Google Scholar
• Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the national comorbidity survey replication. Arch Gen Psychiatry 2005; 62(6):593–602.
   PubMed Web of Science ®Google Scholar
• Kessler RC, Chiu WT, Demler O, Merikangas KR, Walters EE. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the national comorbidity survey replication. Arch Gen Psychiatry 2005; 62(6):617–627.
   PubMed Web of Science ®Google Scholar
• Dixon L. Dual diagnosis of substance abuse in schizophrenia: Prevalence and impact on outcomes. Schizophr Res 1999; 35(Suppl.1(0)):S93–S100.
   Google Scholar
• Morrissey ER, Schuckit MA. Stressful life events and alcohol problems among women seen at a detoxication center. J Stud Alcohol 1978; 39:1559–1576.
   PubMed Web of Science ®Google Scholar
• Gray MJ, Bolton EE, Litz BT. A longitudinal analysis of PTSD symptom course: Delayed-onset PTSD in Somalia peacekeepers. J Consult Clin Psychol 2004; 72(5):909–913.
   PubMed Web of Science ®Google Scholar
• Henwood B, Padgett DK. Reevaluating the self-medication hypothesis among the dually diagnosed. Am J Addict 2007; 16:160–165.
   PubMed Web of Science ®Google Scholar
• Harrington R, Fudge H, Rutter M, Pickles A, Hill J. Adult outcomes of childhood and adolescent depression. Arch Gen Psychiatry 1990; 47(5):465–473.
   PubMed Web of Science ®Google Scholar
• Rao U, Fudge H, Rutter M, Pickles A, Hill J. Unipolar depression in adolescents: Clinical outcome in adulthood. J Am Acad Child Adolesc Psychiatry 1995; 34(5):566–578.
   PubMed Web of Science ®Google Scholar
• Hodgins DC, el-Guebaly N, Armstrong S, Dufour M. Implications of depression on outcome from alcohol dependence: A 3-year prospective follow-up. Alcohol Clin Exp Res 1999; 23(1):51–157.
   Web of Science ®Google Scholar
• Weiss RD, Griffin ML, Mirin SM. Drug abuse as self-medication for depression: An empirical study. Am J Drug Alcohol Abuse 1992; 18(2):121–129.
   PubMed Web of Science ®Google Scholar
• Brown SA, Schuckit MA. Changes in depression among abstinent alcoholics. J Stud Alcohol 1988; 49:412–417.
   PubMed Web of Science ®Google Scholar
• Drake RE, Wallach MA. Substance abuse among the chronic mentally ill. Hosp Community Psychiatry 1989; 40:1041–1046.
   PubMedGoogle Scholar
• DeWit H, Ehlenhuth EH, Hedeker D. Lack of preference for diazepam in anxious volunteers. Arch Gen Psychiatry 1986; 43:533–541.
   PubMed Web of Science ®Google Scholar
• Aharonovich E, Nguyen HT, Nunes EV. Anger and depressive states among treatment-seeking drug abusers: Testing the psychopharmacological specificity hypothesis. Am J Addict 2001; 10(4):327–334.
   PubMed Web of Science ®Google Scholar
• Biala G, Budzynska B. Reinstatement of nicotine-conditioned place preference by drug priming: Effects of calcium channel antagonists. Eur J Pharmacol 2006; 537(1–3):85–93.
   PubMed Web of Science ®Google Scholar
• Spano MS, Fattore L, Cossu G, Deiana S, Fadda P, Fratta W. CB1 receptor agonist and heroin, but not cocaine, reinstate cannabinoid-seeking behaviour in the rat. Br J Pharmacol 2004; 143(3):343–350.
   PubMed Web of Science ®Google Scholar
• Nunes E, Quitkin F, Brady R, Post-Koenig T. Antidepressant treatment in methadone maintenance patients. J Addict Dis 1994; 13(3):13–24.
   PubMed Web of Science ®Google Scholar
• Nunes EV, Quitkin FM, Brady R, Stewart JW. Imipramine treatment of methadone maintenance patients with affective disorder and illicit drug use. Am J Psychiatry 1991; 148(5):667–669.
   PubMed Web of Science ®Google Scholar
• Cornelius JR, Bukstein OG, Birmaher B, Salloum IM, Lynch K, Pollock NK, Gershon S, Clark D. Fluoxetine in adolescents with major depression and an alcohol use disorder: An open-label trial. Addict Behav 2001; 26(5):735–739.
   PubMed Web of Science ®Google Scholar
• Cornelius JR, Salloum IM, Ehler JG, Jarrett PJ, Cornelius MD, Perel JM. Fluoxetine in depressed alcoholics: A double-blind, placebo-controlled trial. Arch Gen Psychiatry 1997; 54(8):700–705.
   Google Scholar
• Nunes EV, Levin FR. Treatment of depression in patients with alcohol or other drug dependence: A meta-analysis. J Am Med Assoc 2004; 291(15):1887–1889.
   PubMed Web of Science ®Google Scholar
• Minkoff K. An integrated treatment model for dual diagnosis of psychosis and addiction. Hosp Community Psych 1989; 40(10):1031–1036.
   PubMedGoogle Scholar
• Helzer JE, Przybeck TR. The co-occurrence of alcoholism with other psychiatric disorders in the general population and its impact on treatment. J Stud Alcohol 1988; 49(3):219–224.
   PubMed Web of Science ®Google Scholar
• Weiss RD, Kolodziej M, Griffin ML, Najavits LM, Jacobson LM, Greenfield SF. Substance use and perceived symptom improvement among patients with bipolar disorder and substance dependence. J Affect Disord 2004; 79:279–283.
   PubMed Web of Science ®Google Scholar
• Tamerin JS, Mendelson JH. The psychodynamics of chronic inebriation: Observations of alcoholics during the process of drinking in an experimental group setting. Am J Psych 1969; 125(7):58–70.
   Web of Science ®Google Scholar
• Kushner MG, Abrams K, Borchardt C. The relationship between anxiety disorders and alcohol use disorders: A review of major perspectives and findings. Clin Psychol Rev 2000; 20(2):149–171.
   PubMed Web of Science ®Google Scholar
• Drake RE, Essock SM, Shaner A, Carey KB, Minkoff K, Kola L, Lynde D, Osher FC, Clark RE, Rickards L. Implementing dual diagnosis services for clients with severe mental illness. Psychiatr Serv 2001; 52(4):469–476.
   PubMed Web of Science ®Google Scholar
• Lembke A, Johnson K, DeBattista C. Depression and smoking cessation: Does the evidence support psychiatric practice? Neuropsychiatr Dis Treat 2007; 3(4):487–493.
   PubMedGoogle Scholar