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The American Journal of Drug and Alcohol Abuse
Encompassing All Addictive Disorders
Volume 4, 1977 - Issue 1
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Original Article

Use of Difenoximide (SC-26100) for Narcotic Detoxification: A Preliminary Tolerance and Efficacy Study

Forest S. Tennant Research Unit Public Health Foundation of Los Angeles County, 3361/2 South Glendora Avenue, West Covina, California, 91790
,
Kenneth D. Krantz Searle Laboratories, Box 5110, Chicago, Illinois, 60680
&
Emanuela I. Dobrin Searle Laboratories, Box 5110, Chicago, Illinois, 60680
Pages 123-135 | Published online: 07 Jul 2009

References

  • Martin W. R., et al. Methadone-A revaluation. Arch. Gen. Psychiatry 1976; 28: 286–298
  • Tennant F. S., Jr., Russell B. A., Casas S. K., Bleich R. N. Heroin detoxification-A comparative study of propoxyphene and methadone. J. Am. Med. Assoc. 1975; 232: 1019–1022
  • Goodman A. L. Use of diphenoxylate hydrochloride in the withdrawal period of narcotic addiction. South. Med. J. 1968; 61: 313–316
  • Glatt M. M., Lewis D. M., Wilson D. T. An oral method of the withdrawal treatment of heroin dependence: A five year's study of a combination of diphenoxylate (Lomotil) and chlormethiozole (Heminevrin). Br. J. Addict. 1970; 65: 237–243
  • Fraser H. F., Isbell H. Human pharmacology and addictiveness of ethyl 1-(3-cyano-3,3-phenylpropyl)-4-piperidine carboxylate hydrochloride (R-1132, diphenoxylate). Bull. Narcotics 1961; 13: 29–43
  • Ament M. E. Diphenoxylate poisoning in children. J. Pediatr. 1969; 74: 462–464
  • Murphy J. B. Project DAWN: The nation's drug abuse warning network. Hosp. Formul. 1975; 10: 390–395
  • Dobrin E. I., Krok D. A., Potts W. J. Successful prevention of morphine withdrawal by oral administration of diphenoxylate and SC-26100, a related compound. Fed. Proc. 1972; 31: 503
  • Cook D. L., Dobrin E. I., Potts W. J. SC-26100, A Narcotic Detoxification Agent-Biological Studies. Chicago, Illinois 1880–1975, Report on file with G. D. Searle & Company, P.O. Box 5110

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