The role of homocysteine, asymmetric dimethylarginine and nitric oxide in pre-eclampsia

References

• ACOG. 2002. Practice Bulletin No. 33: Diagnosis and management of preeclampsia and eclampsia. Obstetrics and Gynecology 99:159–167.
   PubMed Web of Science ®Google Scholar
• Aris A, Benali S, Ouellet A, Moutquin JM, Leblanc S. 2009. Potential biomarkers of preeclampsia: inverse correlation between hydrogen peroxide and nitric oxide early in maternal circulation and at term in placenta of women with preeclampsia. Placenta 30:342–347.
   PubMed Web of Science ®Google Scholar
• Atamer Y, Kocyigit Y, Yokus B, Atamer A, Erden AC. 2005. Lipid peroxidation, antioxidant defense, status of trace metals and leptin levels in preeclampsia. European Journal of Obstetrics, Gynecology, and Reproductive Biology 119:60–66.
   PubMed Web of Science ®Google Scholar
• Baksu A, Taskin M, Goker N, Baksu B, Uluocak A. 2006. Plasma homocysteine in late pregnancies complicated with preeclampsia and in newborns. American Journal of Perinatology 23:31–35.
   PubMed Web of Science ®Google Scholar
• Bhatnagar S, Bhattacharjee J, Vaid M, Madan T, Trivedi SS, Sarma PU. 2007. Inducible nitric oxide synthase (iNOS) gene polymorphism in pre-eclampsia: a pilot study in North India. Australian and New Zealand Journal of Obstetrics and Gynaecology 47:477–482.
   PubMed Web of Science ®Google Scholar
• Chen BM, Xia LW, Zhao RQ. 1997. Determination of N(G),N(G)-dimethylarginine in human plasma by high-performance liquid chromatography. Journal of Chromatography. B, Biomedical Sciences and Applications 692:467–471.
   PubMed Web of Science ®Google Scholar
• Chen G, Wilson R, Cumming G, Walker JJ, Smith WE, McKillop JH. 1993. Prostacyclin, thromboxane and antioxidant levels in pregnancy-induced hypertension. European Journal of Obstetrics, Gynecology, and Reproductive Biology 50:243–250.
   PubMed Web of Science ®Google Scholar
• Cotter AM, Molloy AM, Scott JM, Daly SF. 2003. Elevated plasma homocysteine in early pregnancy: a risk factor for the development of nonsevere preeclampsia. American Journal of Obstetrics and Gynecology 189: 391–396.
   PubMed Web of Science ®Google Scholar
• D'Anna R, Baviera G, Corrado F, Ientile R, Granese D, Stella NC. 2004. Plasma homocysteine in early and late pregnancies complicated with preeclampsia and isolated intrauterine growth restriction. Acta Obstetricia et Gynecologica Scandinavica 83:155–158.
   PubMed Web of Science ®Google Scholar
• El-Salahy EM, Ahmed MI, El-Gharieb A, Tawfik H. 2001. New scope in angiogenesis: role of vascular endothelial growth factor (VEGF), NO, lipid peroxidation, and vitamin E in the pathophysiology of pre-eclampsia among Egyptian females. Clinical Biochemistry 34:323–329.
   PubMed Web of Science ®Google Scholar
• Fickling SA, Williams D, Vallance P, Nussey SS, Whitley GS. 1993. Plasma concentrations of endogenous inhibitor of nitric oxide synthesis in normal pregnancy and pre-eclampsia. Lancet 342:242–243.
   PubMed Web of Science ®Google Scholar
• Herrmann W, Hubner U, Koch I, Obeid R, Retzke U, Geisel J. 2004. Alteration of homocysteine catabolism in pre-eclampsia, HELLP syndrome and placental insufficiency. Clinical Chemistry and Laboratory Medicine 42: 1109–1116.
   PubMed Web of Science ®Google Scholar
• Herrmann W, Isber S, Obeid R, Herrmann M, Jouma M. 2005. Concentrations of homocysteine, related metabolites and asymmetric dimethylarginine in pre-eclamptic women with poor nutritional status. Clinical Chemistry and Laboratory Medicine 43:1139–1146.
   PubMed Web of Science ®Google Scholar
• Holden DP, Fickling SA, Whitley GS, Nussey SS. 1998. Plasma concentrations of asymmetric dimethylarginine, a natural inhibitor of nitric oxide synthase, in normal pregnancy and preeclampsia. American Journal of Obstetrics and Gynecology 178:551–556.
   PubMed Web of Science ®Google Scholar
• Khalil RA, Granger JP. 2002. Vascular mechanisms of increased arterial pressure in preeclampsia: lessons from animal models. American Journal of Physiology. Regulatory, Integrative, and Comparative Physiology 283:R29–R45.
   PubMed Web of Science ®Google Scholar
• Kumar CA, Das UN. 2000. Lipid peroxides, anti-oxidants and nitric oxide in patients with pre-eclampsia and essential hypertension. Medical Science Monitor 6:901–907.
   PubMedGoogle Scholar
• Lowe DT. 2000. Nitric oxide dysfunction in the pathophysiology of preeclampsia. Nitric Oxide 4:441–458.
   PubMed Web of Science ®Google Scholar
• Mao D, Che J, Li K, Han S, Yue Q, Zhu L . 2009. Association of homocysteine, asymmetric dimethylarginine, and nitric oxide with preeclampsia. Archives of Gynecology and Obstetrics 282:371–375.
   PubMed Web of Science ®Google Scholar
• Onalan R, Onalan G, Gunenc Z, Karabulut E. 2006. Combining 2nd-trimester maternal serum homocysteine levels and uterine artery Doppler for prediction of preeclampsia and isolated intrauterine growth restriction. Gynecologic and Obstetric Investigation 61:142–148.
   PubMed Web of Science ®Google Scholar
• Orange SJ, Painter D, Horvath J, Yu B, Trent R, Hennessy A. 2003. Placental endothelial nitric oxide synthase localization and expression in normal human pregnancy and pre-eclampsia. Clinical and Experimental Pharmacology and Physiology 30:376–381.
   PubMed Web of Science ®Google Scholar
• Pettersson A, Hedner T, Milsom I. 1998. Increased circulating concentrations of asymmetric dimethyl arginine (ADMA), an endogenous inhibitor of nitric oxide synthesis, in pre-eclampsia. Acta Obstetricia et Gynecologica Scandinavica 77:808–813.
   PubMed Web of Science ®Google Scholar
• Rajkovic A, Mahomed K, Malinow MR, Sorenson TK, Woelk GB, Williams MA. 1999. Plasma homocyst(e)ine concentrations in eclamptic and preeclamptic African women postpartum. Obstetrics and Gynecology 94: 355–360.
   PubMed Web of Science ®Google Scholar
• Redman CW, Sargent IL. 2005. Latest advances in understanding preeclampsia. Science (New York, N.Y.) 308:1592–1594.
   Google Scholar
• Sandrim VC, Palei AC, Metzger IF, Gomes VA, Cavalli RC, Tanus-Santos JE. 2008. Nitric oxide formation is inversely related to serum levels of antiangiogenic factors soluble fms-like tyrosine kinase-1 and soluble endogline in preeclampsia. Hypertension 52:402–407.
   PubMed Web of Science ®Google Scholar
• Sarandol E, Safak O, Dirican M, Uncu G. 2004. Oxidizability of apolipoprotein B-containing lipoproteins and serum paraoxonase/arylesterase activities in preeclampsia. Clinical Biochemistry 37:990–996.
   PubMed Web of Science ®Google Scholar
• Savvidou MD, Hingorani AD, Tsikas D, Frolich JC, Vallance P, Nicolaides KH. 2003. Endothelial dysfunction and raised plasma concentrations of asymmetric dimethylarginine in pregnant women who subsequently develop pre-eclampsia. Lancet 361:1511–1517.
   PubMed Web of Science ®Google Scholar
• Schonfelder G, Fuhr N, Hadzidiakos D, John M, Hopp H, Paul M. 2004. Pre-eclampsia is associated with loss of neuronal nitric oxide synthase expression in vascular smooth muscle cells of the human umbilical cord. Histopathology 44:116–128.
   PubMed Web of Science ®Google Scholar
• Serdar Z, Gur E, Develioglu O, Colakogullari M, Dirican M. 2002. Placental and decidual lipid peroxidation and antioxidant defenses in pre-eclampsia. Lipid peroxidation in preeclampsia. Pathophysiology 9:21.
   PubMedGoogle Scholar
• Shaamash AH, Elsnosy ED, Makhlouf AM, Zakhari MM, Ibrahim OA, El-Dien HM. 2000. Maternal and fetal serum nitric oxide (NO) concentrations in normal pregnancy, pre-eclampsia and eclampsia. International Journal of Gynaecology and Obstetrics 68:207–214.
   PubMed Web of Science ®Google Scholar
• Sibai B, Dekker G, Kupferminc M. 2005. Pre-eclampsia. Lancet 365:785–799.
   PubMed Web of Science ®Google Scholar
• Sikkema JM, van Rijn BB, Franx A, Bruinse HW, de Roos R, Stroes ES . 2001. Placental superoxide is increased in pre-eclampsia. Placenta 22:304–308.
   PubMed Web of Science ®Google Scholar
• Speer PD, Powers RW, Frank MP, Harger G, Markovic N, Roberts JM. 2008. Elevated asymmetric dimethylarginine concentrations precede clinical preeclampsia, but not pregnancies with small-for-gestational-age infants. American Journal of Obstetrics and Gynecology 198:112 e111–e117.
   Google Scholar
• Stuhlinger MC, Tsao PS, Her JH, Kimoto M, Balint RF, Cooke JP. 2001. Homocysteine impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine. Circulation 104:2569–2575.
   PubMed Web of Science ®Google Scholar
• Var A, Yildirim Y, Onur E, Kuscu NK, Uyanik BS, Goktalay K . 2003. Endothelial dysfunction in preeclampsia. Increased homocysteine and decreased nitric oxide levels. Gynecologic and Obstetric Investigation 56: 221–224.
   PubMed Web of Science ®Google Scholar
• Vural P. 2002. Nitric oxide/endothelin-1 in pre-eclampsia. Clinica Chimica Acta 317:65–70.
   PubMed Web of Science ®Google Scholar
• Wang Y, Walsh SW. 1996. Antioxidant activities and mRNA expression of superoxide dismutase, catalase, and glutathione peroxidase in normal and preeclamptic placentas. Journal of the Society for Gynecologic Investigation 3:179–184.
   PubMedGoogle Scholar
• Yu CK, Lakasing L, Papageorghiou AT, Spencer K, Nicolaides KH. 2004. Uterine artery Doppler and mid-trimester maternal plasma homocysteine in subsequent pre-eclampsia. Journal of Maternal-Fetal and Neonatal Medicine 16:134–139.
   PubMedGoogle Scholar
• Zhang LC, Liang GD, Yang MG, Zhang YH, Shi FT. 1991. Significance of changes in serum superoxide dismutase level in hypertensive syndrome of pregnancy. Chinese Medical Journal 104:472–475.
   PubMed Web of Science ®Google Scholar