113
Views
5
CrossRef citations to date
0
Altmetric
Research Article

The evaluation of genotoxic potential of ornidazole, nitroimidazole, in lymphocyte culture of patients with amebiasis

, , , &
Pages 162-166 | Received 25 Feb 2010, Accepted 19 Apr 2010, Published online: 12 Feb 2011

References

  • Bendensky A, Menendez A, Ostrosky-Wegman P (2002). Is metranidazole carcinogenic?. Mutat. Res. 511, 133–144.
  • Brismar BC, Edlund C, Malmborg AS, Nord CE (1990). Ecological impact of antimicrobial prophylaxis on intestinal microflora in patients undergoing colorectal surgery. Scand J Infect Dis Suppl. 70, 25–30.
  • Cantelli-Forti G, Aicardi G, Guerra MC, Barbaro AM, Biagi GL (1983). Mutagenicity of a series of 25 nitroimidazoles and two nitro thiazoles in Salmonella typhimurium. Teratog. Carcinog. Mutagen. 3, 51–63.
  • Cerna M, Dobias L, Hajek V, Rossner P, Sram RJ (1990). Mutagenic activity analysis of body fluids in the first phase of clinical drug trials. Cesk. Farm. 39, 127–130.
  • Chin JB, Sheinin DM, Rauth AM (1978). Screening for the mutagenicity of nitro-group containing hypoxic cell radiosensitizers using Salmonella typhimurium strains TA 100 and TA98. Mutat. Res. 58, 1–10.
  • Connor TH, Stoeckel M, Evrard J, Legator MS (1977). The contribution of metronidazole and two metabolites to the mutagenic activity detected in urine of treated humans and mice. Cancer Res. 37, 629–633.
  • Countryman P, Heddle J (1976). The production of micronuclei from chromosome aberrations in irradiated cultures of human lymphocytes. Mutat. Res; 41, 321–332.
  • De Meo M, Vanelle P, Bernadini E, Laget M, Maldonado J, Jentzer O, Crozet MP, Dumenil G (1992). Evaluation of the mutagenic and genotoxic activities of 48 nitroimidazoles and related imidazole derivatives by the Ames test and the SOS chromotest. Environ. Mol. Mutagen. 19, 167–181.
  • Edwards DI (1986). Reduction of nitroimidazoles in vitro and DNA damage. Biochem. Pharmacol. 35, 53–58.
  • Elizondo G, Gonsebatt ME, Salazar AM, Lares I, Santiago P, Herrera J, Hong E, Ostrosky-Wegman P (1996). Genotoxic effects of metronidazole. Mutat. Res. 370, 75–80.
  • Gebhart E (1981). Sister chromatid exchanges and structural chromosome aberration in mutagenicity testing. Hum. Genet. 58, 235–254.
  • Gupta RL, Vats V, Juneja TR (1996). Activation of tinidazole, an antiprotozoal drug to a mutagen by mammalian liver S9. Mutat. Res. 370, 195–201.
  • IARC (International Agency for Research on Cancer). (1987). IARC monographs on the evaluation of carcinogenic risk to humans. Suppl. 7. Overall evaluations of Carcinogenicity: An updating of IARC monographs volumes 1–42 (pp 250–252). International Agency for Research on Cance (pp250-252), Lyon.
  • LaRusso NF, Tomasz M, Müller M, Lipman R (1977). Absence of strand breaks in deoxyribonucleic acid treated with metronidazole. Antimicrob. Agents and Chemo. 13, 19–24.
  • Latt S.A (1981). Sister chromatid exchange formation. Annu. Rev. Genet. 15, 11–55.
  • Leal-Garza CH, Montes de Oca-Luna R, Baca-Sevilla S, Garza-Chapa R (1984). Tinidazole and emetine cytogenetic effects evaluated by the micronucleus test in mice. Arch. Invest. Med. 15, 311–316.
  • Lopez Nigro MM, Gadano AB, Carballo MA (2001). Evaluation of genetic damage induced by a nitroimidazole derivative in human lymphocytes: Tinidazole (TNZ). Toxicol. In Vitro, 15, 209–213.
  • Lopez Nigro MM, Palermo AM, Mudry MD, Carballo MA (2003). Cytogenetic evaluation of two nitroimidazole derivatives. Toxicology In Vitro, 17, 35–40.
  • Ludlum DB, Colinas RJ, Kirk MC, Mehta JR (1988). Reaction of reduced metronidazole with guanosine to form an unstable adduct. Carcinogen. 8, 593–596.
  • Martelli A, Allavena A, Robbiano L, Mattioli F, Brambilla G (1990). Comparison of the sensitivity of human and rat hepatocytes to the genotoxic effects of metronidazole. Pharmacol. Toxicol. 66, 329–334.
  • Menendez D, Rojas E, Herrera LA, Lopez MC, Sordo M, Elizondo G, Ostrosky-Wegman P (2001). DNA breakage due to metronidazole treatment. Mutat. Res. 478, 153–158.
  • Oderda G, Ponzetto A, Boero M, Bellis D, Forni M, Vaira D, Ansaldi N (1997). Family treatment of symptomatic children with Helicobacter pylori infection. Ital J Gastroenterol. Hepatol. 29, 509–514.
  • Perry P and Wolff S (1974). New Giemsa method for the differential staining of sister chromatids. Nature 251, 156–158.
  • Reitz M, Rumpf M, Knitza R (1991). DNA single strand-breaks in lymphocytes after metronidazole therapy. Arzneimittelforschung; 41, 155–156.
  • Robinson DM, Abdel-Rahman SM, Nahata MC (1997). Guidelines for the treatment of Helicobacter pylori in the pediatric population. Ann. Pharmacother. 31, 1247–1249.
  • Rodriguez Ferreiro G, Cancino Badías L, Lopez-Nigro M, Palermo A, Mudry M, González Elio P, Carballo MA (2002). DNA single strand breaks in peripheral blood lymphocytes induced by three nitroimidazole derivatives. Toxicol Lett. 132, 109–115.
  • Roe FJ (1985). Safety of nitroimidazoles. Scand J Infect. Dis. Suppl. 46, 72–81.
  • Rosenblatt JE, Edson RS (1987). Symposium on antimicrobial agents. Metronidazole. Mayo Clin. Proc. 62, 1013–1017.
  • Shaheen S, Rani TSH, Begum S, Ishaq M (1993). Effect of tinidazole on in vitro lymphokine production. Medical. Science. Res. 21, 19.
  • Tocher JH, Edwards DI (1994). Evidence for the direct interaction of reduced metronidazole derivatives with DNA bases. Biochem. Pharmacol. 48, 1089–1094.
  • Tucker JD, Preston RJ (1996). Chromosome aberrations, micronuclei, aneuploidy, sister chromatid exchanges, and cancer risk assessment. Mutat. Res. 365, 147–159.
  • Voogd CE, Van der Stel JJ, Jacobs JJ (1974). The mutagenic action of nitroimidazoles. I. Metronidazole, nimorazole, dimetridazole and ronidazole. Mutat. Res. 26, 483–490.
  • Voogd CE, Van der Stel JJ, Jacobs JJ (1977). The mutagenic action of nitroimidazoles. II. Tinidazole, ipronidazole, panidazole and ornidazole. Mutat. Res. 48, 155–161.
  • Zahoor A, Lafleur MV, Knight RC, Loman H, Edwards DI (1987). DNA damage induced by reduced nitroimidazole drugs. Biochem Pharmacol; 36, 3299–3304.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.