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Review Article

Tenuous dose-response correlations for common disease states: case study of cholesterol and perfluorooctanoate/sulfonate (PFOA/PFOS) in the C8 Health Project

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Pages 396-404 | Received 03 Jun 2010, Accepted 15 Apr 2011, Published online: 19 Jul 2011

References

  • Butenhoff, J., Costa, G., Elcombe, C., Farrar, D., Hansen, K., Iwai, H., et al. (2002). Toxicity of perfluorooctanoate in male cynomologus monkeys after oral dosing for 6 months. Toxicol Sci 69:244–257.
  • C8 Science Panel. (October 8, 2008). Overview of first C8 Science Panel results from study 1. Available at: www.C8SciencePanel.org. Accessed date is 9/7/09
  • C8 Science Panel. (October 15, 2008). Available at: www.C8SciencePanel.org. Accessed date is 9/8/09
  • Centers for Disease Control and Prevention. (2010). U.S. obesity trends. Available at: http://www.cdc.gov/data/trends.html.
  • Chen, Y. M., Guo, L. H. (2009). Fluorescence study on site-specific binding of perfluoroalkyl acids to human serum albumin. Arch Toxicol 83:255–261.
  • Costa, G., Sartoir, S., Consonni, D. (2009). Thirty years of medical surveillance in perfluorooctanoic acid production workers. J Occup Environ Med 51:364–372.
  • Emmett, E. A., Zhang, H., Shofer, F. S., Freeman, D., Desai, C., Shaw, L. M., et al. (2006). Community exposure to perfluorooctanoate: relationship between serum levels and certain health parameters. J Occup Environ Med 48:771–779.
  • Flegal, K. M., Carroll, M. D., Ogden, C. L., Curtin, L. R. (2010). Prevalence and trends in obesity among US adults, 1999–2008. JAMA 303:1–10.
  • Frisbee, S. J., Brooks, A. P., Jr., Maher, A., Flensberg, P., Arnold, S., Fletcher, T., et al. (2009). The C8 health project: design, methods, and participants. Environ Health Perspect 117:1873–1882.
  • Gostynski, M., Gutzwiller, F., Kuulasmaa, K., Döring, A., Ferrario, M., Grafnetter, D., et al. (2004). Analysis of the relationship between total cholesterol, age, body mass index among males and females in the WHO MONICA project. Int J Obes Relat Metab Disord 28:1082–1090.
  • Han, X., Snow, T. A., Kemper, R. A., Jepson, G. W. (2003). Binding of perfluorooctanoic acid to rat and human plasma proteins. Chem Res Toxicol 16:775–781.
  • Hill, A. B. (1965). The environment and disease: association or causation? Proc R Soc Med 58:295–300.
  • Kennedy, G. L., Jr., Butenhoff, J. L., Olsen, G. W., O’Connor, J. C., Seacat, A. M., Perkins, R. G., et al. (2004). The toxicology of perfluorooctanoate. Crit Rev Toxicol 34:351–384.
  • Kerger, B. D., Scott, P. K., Pavuk, M., Gough, M., Paustenbach, D. J. (2011). No dose-response relationship for dioxin and diabetes among Ranch Hand Vietnam veterans: evidence for reverse causation. (submitted).
  • Lundin, J. L., Alexander, B. H., Olsen, G. W., Church, T. R. (2009). Ammonium perfluorooctanoate production and occupational mortality. Epidemiology 20:921–928.
  • Martin, M. T., Brennan, R. J., Hu, W., Ayanoglu, E., Lau, C., Ren, H., et al. (2007). Toxicogenomic study of triazole fungicides and perfluoroalkyl acids in rat livers predicts toxicity and categorizes chemicals based on mechanism of toxicity. Toxicol Sci 97:595–613.
  • Melzer, D., Rice, N., Depledge, M. H., Henley, W. E., Galloway, T. S. (2010). Association between serum perfluorooctanoic acid (PFOA) and thyroid disease in the U.S. National Health and Nutrition Examination Survey. Environ Health Perspect 118:686–692.
  • Nelson, J. W., Hatch, E. E., Webster, T. F. (2010). Exposure to polyfluoroalkyl chemicals and cholesterol, body weight, and insulin resistance in the general U.S. population. Environ Health Perspect 118:197–202.
  • Olsen, G. W., Zobel, L. R. (2007). Assessment of lipid, hepatic, and thyroid parameters with serum perfluorooctanoate (PFOA) concentrations in fluorochemical production workers. Int Arch Occup Environ Health 81:231–246.
  • Olsen, G. W., Burris, J. M., Mandel, J. H., Zobel, L. R. (1999). Serum perfluorooctane sulfonate and hepatic and lipid clinical chemistry tests in fluorochemical production employees. J Occup Environ Med 41:799–806.
  • Olsen, G. W., Burris, J. M., Burlew, M. M., Mandel, J. H. (2003). Epidemiologic assessment of worker serum perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) concentrations and medical surveillance examinations. J Occup Environ Med 45:260–270.
  • Rader, D. J., Hobbs, H. H. (2005). Disorders of lipoprotein metabolism. In: Kasper, D. L., Fauci, A. S., Longo, D. L., Braunwald, E., Hauser, S. L., Jameson, J. L. ( Eds.), Harrison’s principles of internal medicine, 16th ed. ( pp. 2286–2303). New York: McGraw-Hill.
  • Sakr, C. J., Kreckmann, K. H., Green, J. W., Gillies, P. J., Reynolds, J. L., Leonard, R. C. (2007a). Cross-sectional study of lipids and liver enzymes related to a serum biomarker of exposure (ammonium perfluorooctanoate or APFO) as part of a general health survey in a cohort of occupationally exposed workers. J Occup Environ Med 49:1086–1096.
  • Sakr, C. J., Leonard, R. C., Kreckmann, K. H., Slade, M. D., Cullen, M. R. (2007b). Longitudinal study of serum lipids and liver enzymes in workers with occupational exposure to ammonium perfluorooctanoate. J Occup Environ Med 49:872–879.
  • Sakr, C. J., Symons, J. M., Kreckmann, K. H., Leonard, R. C. (2009). Ischaemic heart disease mortality study among workers with occupational exposure to ammonium perfluorooctanoate. J Occup Environ Med 66:699–703.
  • Schober, S. E., Carroll, M. D., Lacher, D. A., Hirsch, R. (2007). High serum total cholesterol—an indicator monitoring cholesterol lowering efforts: U.S. adults, 2005–2006. NCHS Data Brief No.2. 2007:1–8. Available at: http://www.cdc.gov/nchs/data/databriefs/db02.pdf. Accessed date is 9/8/09
  • Seacat, A. M., Thomford, P. J., Hansen, K. J., Olsen, G. W., Case, M. T., Butenhoff, J. L. (2002). Subchronic toxicity studies on perfluorooctanesulfonate potassium salt in cynomologus monkeys. Toxicol Sci 68:249–264.
  • Steenland, K., Jin, C., MacNeil, J., Lally, C., Ducatman, A., Vieira, V., et al. (2009a). Predictors of PFOA levels in a community surrounding a chemical plant. Environ Health Perspect 117:1083–1088.
  • Steenland, K., Tinker, S., Frisbee, S., Ducatman, A., Vaccarino, V. (2009b). Association of perfluorooctanoic acid and perfluorooctane sulfonate with serum lipids among adults living near a chemical plant. Am J Epidemiol 170:1268–1278.
  • Steenland, K., Tinker, S., Shankar, A., Ducatman, A. (2010). Association of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) with uric acid among adults with elevated community exposure to PFOA. Environ Health Perspect 118:229–233.
  • Thibodeaux, J. R., Hanson, R. G., Rogers, J. M., Grey, B. E., Barbee, B. D., Richards, J. H., et al. (2003). Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse. I: maternal and prenatal evaluations. Toxicol Sci 74:369–381.
  • WVU Database. (2009). West Virginia University School of Medicine, tabular summary for clinical lab values within population C8/PFOA deciles, stratified by age gender. Available at: http://www.hsc.wvu.edu/som/cmed/c8/. Accessed date is 9/8/09
  • Wolf, C. J., Takacs, M. L., Schmid, J. E., Lau, C., Abbott, B. D. (2008). Activation of mouse and human peroxisome proliferator-activated receptor alpha by perfluoroalkyl acids of different functional groups and chain lengths. Toxicol Sci 106:162–171.
  • Wu, L.-L., Gao, H.-W., Gao, N.-Y., Chen, F. F., Chen, L. (2009). Interaction of perfluorooctanoic acid with human serum albumin. BMC Struct Biol 9:31. Available at: http://www.biomedcentral.com/1472–6807/9/31. Accessed date is 9/8/09
  • Wynder, E. L., Schlesselman, J., Wald, N., Lilienfeld, P., Stolley, P., Higgins, I. T. T., et al. (1982). Conference report: weak associations in epidemiology and their interpretation. Prev Med 11:464–476.

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