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Drug and Chemical Toxicology Volume 35, 2012 - Issue sup1
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Research Article

Whole-body tissue distribution of total radioactivity in rats after oral administration of [14C]-bilastine

María Luisa LuceroFaes Farma, S.A., R&D and Innovation Department, Leioa, SpainCorrespondence[email protected]
, BSc &
Andrew B. PattersonCharles River Laboratories, Preclinical Services, Edinburgh, UK
, BSc
Pages 1-7 | Received 28 Mar 2012, Accepted 31 Mar 2012, Published online: 22 May 2012

References

  • Bachert, C., Kuna, P., Zuberbier, T. (2010). Bilastine in allergic rhinoconjunctivitis and urticaria. Allergy 65 (Suppl. 93):1–13.
  • Church, M. K. (2011). Safety and efficacy of bilastine: a new H1-antihistamine for the treatment of allergic rhinoconjunctivitis and urticaria. Expert Opin Drug Saf 10:779–793.
  • Fujii, T., Tanaka, K., Matsumoto, S., Hatoyama, T., Nomura, N., Tagawa, M., et al. (1994). Absorption, distribution, metabolism, and excretion of [14C]ebastine after repeated oral administration in rats. Arzneimittelforschung 44:538–543.
  • Jauregizar, N., de la Fuente, L., Lucero, M. L., Sologuren, A., Leal, N., Rodríguez, M. (2009). Pharmacokinetic-pharmacodynamic modelling of the antihistaminic (H1) effect of bilastine. Clin Pharmacokinet 48:543–554.
  • Motoji, N., Hayama, E., Shigematsu, A. (1995). Radioluminography for quantitative autoradiography of 14C. Eur J Drug Metab Pharmacokinet 20:89–105.
  • Sainio, E. L., Sainio, P. (1991). A quantitative method for measuring labeled compounds with whole-body autoradiography in tissue sections. J Pharmacol Methods 26:53–59.
  • Sologuren, A., Valiente, R., Allison, M., Tyl, B. (2008). A lack of significant effect of bilastine on ventricular repolarization. A thorough QT/QTc study. Allergy 63 (Suppl. 88):85.
  • Solon, E. G., Schweitzer, A., Stoeckli, M., Prideaux, B. (2010). Autoradiography, MALDI-MS, and SIMS-MS imaging in pharmaceutical discovery and development. AAPS J 12:11–26.
  • Solon, E. G. (2012). Use of radioactive compounds and autoradiography to determine drug tissue distribution. Chem Res Toxicol 25:543–555.
  • Tyl, B., Kabbaj, M., Azzam, S., Sologuren, A., Valiente, R., Reinbolt, E.,et al. (2011). Lack of significant effect of bilastine administered at therapeutic and supratherapeutic doses and concomitantly with ketoconazole on ventricular repolarization: results of a Thorough QT Study (TQTS) with QT-concentration analysis. J Clin Pharmacol 2011 June 3. [Epub ahead of print].
  • Wang, L., He, K., Maxwell, B., Grossman, S. J., Tremaine, L. M., Humphreys, W. G., et al. (2011). Tissue distribution and elimination of [14C]apixaban in rats. Drug Metab Dispos 39:256–264.
  • Zane, P. A., O’Buck, A. J., Walter, R. E., Robertson, P., Tripp, S. L. (1997). Validation of procedures for quantitative whole-body autoradiography using digital imaging. J Pharm Sci 86:733–738.
  • Zhou, S. F. (2008) Structure, function, and regulation of P-glycoprotein and its clinical relevance in drug disposition. Xenobiotica 38:802–832.

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